Is lateral localisation of placenta a risk factor for adverse perinatal outcomes?

Seçkin, Kerem Doğa; Çakmak, Bülent; Karslı, Mehmet Fatih; Yeral, Mahmut; Gültekin, İsmail Burak; M, Öz; Danışman, Nuri

doi:10.3109/01443615.2015.1007343

Cited by 20 publications

(33 citation statements)

References 14 publications

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“…In some studies, posterior or central (anterior or posterior) placental location has been reported to be associated with a lower risk of complications than other placental locations, and consequently, posterior placental location was chosen as the reference category …”

Section: Methodsmentioning

confidence: 99%

“…As the anatomical conditions vary across different areas of the uterus, both with respect to the shape of the cavity and the blood supply, other placental locations than previa may also be associated with adverse pregnancy, delivery and infant outcomes. Several previous studies have indicated this, but study groups have been relatively small and results are partly contradictory …”

Section: Introductionmentioning

confidence: 94%

“…Several previous studies have indicated this, but study groups have been relatively small and results are partly contradictory. [4][5][6][7][8][9][10][11] We therefore conducted a large-scale, population-based cohort study in nulliparous women with the aim to investigate if placental location other than previa at the second-trimester ultrasound screening is associated with adverse pregnancy, delivery and infant outcomes.…”

Section: Introductionmentioning

confidence: 99%

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Placental location and pregnancy outcomes in nulliparous women: A population‐based cohort study

Granfors

Stephansson

Endler

et al. 2019

Acta Obstet Gynecol Scand

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Introduction The impact of placenta previa on pregnancy, delivery and infant outcomes has been extensively studied. However, less is known about the possible association of placental location other than previa with pregnancy outcomes. The aim of this study was to investigate if placental location other than previa is associated with adverse pregnancy, delivery and infant outcomes. Material and methods This is a population‐based cohort study, with data from the regional population‐based Stockholm‐Gotland Obstetric Cohort, Sweden, from 2008 to 2014. The study population included 74 087 nulliparous women with singleton pregnancies resulting in live‐born infants, with information about placental location from the second‐trimester ultrasound screening. The association between placental location (fundal, lateral, anterior or posterior) and pregnancy outcomes was estimated using logistic regression analysis. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated, and adjustments were made for maternal age, height, country of birth, smoking in early pregnancy, sex of the infant and in vitro fertilization. Main outcome measures were pregnancy, delivery and infant outcomes. Results Compared with posterior placental location, fundal and lateral placental locations were associated with a number of adverse pregnancy outcomes, the most important being: very preterm birth (<32 weeks of gestation) (adjusted OR [aOR] 1.78, 95% CI 1.18‐2.63 and aOR 2.12, 95% CI 1.39‐2.25, respectively), moderate preterm birth (32‐36 weeks of gestation) (aOR 1.23, 95% CI 1.001‐1.51 and aOR 1.62, 95% CI 1.32‐2.00, respectively), small‐for‐gestational‐age birth (aOR 1.67, 95% CI 1.34‐2.07 and aOR 1.77, 95% CI 1.39‐2.25, respectively) and manual removal of the placenta in vaginal births (aOR 3.27, 95% CI 2.68‐3.99 and aOR 3.27, 95% CI 2.60‐4.10, respectively). Additionally, lateral placental location was associated with preeclampsia (aOR 1.30, 95% CI 1.03‐1.65) and severe postpartum hemorrhage (aOR 1.42, 95% CI 1.27‐1.82). Conclusions Compared with posterior placental location, fundal and lateral placental locations are associated with a number of adverse pregnancy, delivery and infant outcomes.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Placental location and pregnancy outcomes in nulliparous women: A population‐based cohort study

Granfors

Stephansson

Endler

et al. 2019

Acta Obstet Gynecol Scand

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“…Seckin et al prospective study also showed the relationship between lateral placenta and development of preeclampsia (4.5% versus 1.6% in lateral and central placenta respectively) and fetal growth restriction. 7 Gonser et al study (n=148) also showed odd ratio 3.1 in lateral (n=115) versus central (n=33) group for development of preeclampsia. 8 Fung et al also studied prospectively the location of placenta and pregnancy outcome and found the odds ratio of 2.04 for preeclampsia and 1.82 for small for gestational age (SGA) in lateral group.…”

Section: Discussionmentioning

confidence: 84%

Are preeclampsia and small for gestational age baby could be predicted by placental location?

Singh¹,

Vats²,

Sharma³

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Objective: Preeclampsia is one of the major cause of maternal and perinatal mortality and morbidity. The pathophysiology is complex and involves multiple organs. The purpose of this study was to find out whether the placental laterality as a predictor of preeclampsia and small for gestational age baby.Methods: This was prospective observational study conducted from February 2015 to December 2015, in a tertiary care hospital of Delhi. 347 antenatal patients attending obstetrics OPD without high risk factors were enrolled. After enrolment 50 patients were lost to follow up and 27 not delivered in our hospital. Ultrasonography for placental localization was done at 18-24 weeks of pregnancy. Patients were followed till delivery for pregnancy outcomes such as preeclampsia, small for gestation age (SGA) baby and mode of delivery. Placenta locations were divided into lateral (either right or left) and central (anterior, posterior or fundal).Results: Out of 347, a total of 270 patients were analysed, 39 (14.4%) had lateral placenta and among them 17 (43.5%) developed preeclampsia and 24 (61.5%) had small for gestational age baby (p<0.001). 231 (85.5%) had central placenta and among them 49 (21.2%) developed preeclampsia and 63 (27.2%) had small for gestational age baby (p <0.001).Conclusions: Laterally located placenta had significant association with preeclampsia and small for gestational age babies.

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“…Non-central placental location in the second trimester was associated with an increase risk of adverse obstetric outcomes including preeclampsia [OR = 2.27; 95 % confidence intervals (CIs), 1.31-3.93]. Secken et al [7] also found preeclampsia significantly higher in the lateral placental location group (4.5 vs. 1.6 %; p = 0.027).…”

Section: Discussionmentioning

confidence: 98%

Utility of Placental Laterality and Uterine Artery Doppler Abnormalities for Prediction of Preeclampsia

Yousuf

Ahmad

Qadir

et al. 2016

J Obstet Gynecol India

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Objective To find out whether placental laterality and abnormal uterine artery waveform and resistance index, as determined by antenatal ultrasonography and Doppler, can be used as a predictor for the development of preeclampsia. Methods This prospective observational cohort study was conducted from August 2013 to October 2014. Two hundred and one (201) normotensive, primigravida women with singleton pregnancies attending the antenatal clinics without any high-risk factor for development of hypertension were subjected to ultrasonography at 18-22 weeks of gestation to determine the placenta location. All the subjects with lateral placentas were subjected to Doppler ultrasonography to look for abnormal Doppler waveform and resistance index. They were followed for the development of preeclampsia till 40 weeks of gestation or delivery. Result In subjects with lateral placentas alone (n = 33), 2 (6 %) developed preeclampsia while as those with lateral placentas with Doppler abnormality (n = 38), 35 (92 %) developed preeclampsia (p \ 0.001). The overall risk of developing preeclampsia with laterally located placenta was 9.27 (odds ratio), and 95 % confidence interval was (4. 30-19.98). Conclusion Pregnant women with lateral placentas are at significant risk for development of preeclampsia. Lateral placentas when associated with uterine artery Doppler abnormality, risk for development of preeclampsia increases significantly as compared to lateral placentas alone.

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Is lateral localisation of placenta a risk factor for adverse perinatal outcomes?

Cited by 20 publications

References 14 publications

Placental location and pregnancy outcomes in nulliparous women: A population‐based cohort study

Placental location and pregnancy outcomes in nulliparous women: A population‐based cohort study

Are preeclampsia and small for gestational age baby could be predicted by placental location?

Utility of Placental Laterality and Uterine Artery Doppler Abnormalities for Prediction of Preeclampsia

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