Is lateral bias anomalous in early-onset schizophrenia? Selected comparisons with normal populations

Collinson, Simon L.; Phillips, Tania J.; James, Anthony; Quested, Digby; Crow, Timothy J.

doi:10.1016/j.psychres.2003.12.018

Cited by 26 publications

(18 citation statements)

References 25 publications

(29 reference statements)

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“…Our study found no association between age at onset of illness and handedness in schizophrenia/ schizoaffective disorder. This finding is inconsistent with the view that lateralization is anomalous in schizophrenia early in the course of illness, as was demonstrated in the study by Collinson et al 18 .…”

Section: Discussioncontrasting

confidence: 84%

“…The degree to which this deviation differs from the onset of schizophrenia amongst the older schizophrenia population is not yet clear, but the evidence suggests that anomalous hand preference may be more common or possibly more severe in patients with early-onset schizophrenia. 18 Although the etiology of handedness, brain asymmetry and schizophrenia is likely to be complex, the discovery of the LRRTM1 gene may reveal new insights in establishment/ maintenance of normal/abnormal brain development, and its relationship with diseases such as schizophrenia. 19 By clinically assessing the possible relationship between handedness, schizophrenia and the LRRTM1 gene, further light may be shed on the importance of the LRRTM1 gene in schizophrenia, which may pave the way for further research.…”

Section: Journal Of Psychiatry • January 2014mentioning

confidence: 99%

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Handedness in schizophrenia and schizoaffective disorder in an afrikaner founder population

Mataboge¹

2014

Afr J Psychiatry

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Objective: An association between the Leucine-rich repeat trans membrane neuronal 1 gene (LRRTM1), schizophrenia/ schizoaffective disorder and handedness was recently claimed to be established. This study aimed to test the hypothesis that Afrikaner patients with schizophrenia/schizoaffective disorder are more non-right handed than their non-affected firstdegree relatives and that of two separate control groups. The association between handedness, gender and age at onset of illness in the patients group was also determined. Method: Two cross-sectional studies were carried out, which compared the handedness of a group of 100 (30 females and 70 males) Afrikaner patients with schizophrenia/schizoaffective disorder, their non-affected first-degree relatives, and two separate control groups. Handedness was determined by the Edinburg Handedness Inventory (EHI). Results: Patients were found to be more right-handed than expected with only 17 out of 100 being non-right-handed compared to 11 out of 100 non-affected relatives; 36 out of 100 students and 75 out of 500 nonaffected Afrikaner participants. The students were significantly more non-right handed than the patient and family groups but no difference in handedness was found when comparing the patients, family members and 500 participant control group. There was no significant difference between age at onset of illness and handedness. A significant association between female gender and non-right handedness in the patient group was found but no gender difference in the family and student groups. A highly significant association was found between the male gender of the patients and student control group regarding handedness. A significant difference was found between the median EHI raw scores of the patients and the family members. The median EHI raw scores of the patients were significantly lower than their paired family members. Conclusion: The study failed to prove a leftward shift of handedness in the patients with Schizophrenia and Schizoaffective disorder in the Afrikaner Founder population. Whether or not LRRTM1 is indeed the genetic basis of handedness, remains unclear.

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Section: Discussioncontrasting

confidence: 84%

Section: Journal Of Psychiatry • January 2014mentioning

confidence: 99%

Handedness in schizophrenia and schizoaffective disorder in an afrikaner founder population

Mataboge¹

2014

Afr J Psychiatry

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“…Subjects were classified as "right," "left," and "either" depending on preference. Foot preference was compared with hand preference to determine hand-foot congruence (Collison et al, 2004;Martin & Machado, 2005).…”

Section: Methodsmentioning

confidence: 99%

Relationships Between Hand and Foot Preferences

Barut

Özer

Sevinç

et al. 2007

International Journal of Neuroscience

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178C. BARUT ET AL.(22.11 ± 2.07). Of the right-handed men, 75.5% preferred the right foot, 7.1% the left foot, and 17.4% both feet. Of ambidextrous men, 44.0% preferred the right foot, 28.0% the left foot, and 28.0% both feet. Of left-handed men, 32.3% preferred the right foot, 56.9% the left foot, and 10.8% both feet. The differences between these percentages were found to be statistically significant. Of the right-handed women, 89.9% preferred the right foot, left foot 1.2%, both feet 8.9%, whereas 50.0% preferred the right foot, 12.5% the left foot, and 37.5% both feet in the ambidextrous women. In the left-handed women, 8.8% preferred the right foot, 79.4% the left foot, and 11.8% both feet. The differences between these percentages were found to be statistically significant. The results suggested that the cultural differences among the different study groups may be the reason for the inconsistencies with regard to hand and foot preferences. Moreover, the results may bring insight into the foot preference in relation to hand preference in the Turkish population.

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“…67) , a esquizofrenia (e.g. 68) , as doenças do sistema imunitá-rio (e.g. 69) ou desordens desenvolvimentais (e.g.…”

Section: Assimetrias Manuais: Período Pré-escolar E Escolarunclassified

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2010

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Is lateral bias anomalous in early-onset schizophrenia? Selected comparisons with normal populations

Cited by 26 publications

References 25 publications

Handedness in schizophrenia and schizoaffective disorder in an afrikaner founder population

Handedness in schizophrenia and schizoaffective disorder in an afrikaner founder population

Relationships Between Hand and Foot Preferences

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