Is laparoscopic distal pancreatectomy decreasing morbidity? A multicentre study (ERPANDIS)

Abstract

were analysed. The register is validated and has a national coverage of 74% for 2010, increasing to 91% in 2017. Comparisons between groups were performed using non-parametric tests. Results: In total, 8911 patients were registered with periampullary cancers, 4345 (49%) were women and 4566 (51%) were men. Median age was 71 years (IQR 64-77) for both women and men. Women were subject to pancreatoduodenectomy to a lesser proportion than men 38% vs. 42%; p<0.001. At surgery, resection was performed at equal rates, 72% vs. 71%, p=0.411, and there was neither any difference in the venous resection rate 19% vs. 17%, p=0.120. Major intraoperative bleeding (>1000ml) was less frequent in women, 19% vs. 29% p<0.001, but severe postoperative complications (Clavien-Dindo 3-5) did not differ between the sexes 21% vs. 22%; p=0.447. The frequency of radical resection (R0) was similar in both groups, 66% vs. 63%; p=0.132. Conclusion: These preliminary analysis of national data on periampullary neoplasms suggest a possible selection in favour of the male patients that more often were subject to pancreatoduodenectomy. At surgery women and men were to an equal extent radically resected and there were no differences in postoperative complications.