Is Kimura’s disease associated with juvenile temporal arteritis? A case report and literature review of all juvenile temporal arteritis cases

Tomizuka, Takafumi; Kikuchi, Hirotoshi; Asako, Kurumi; Tsukui, Daisuke; Kimura, Yoshitaka; Kikuchi, Yoshinao; Sasajima, Yuko; Kono, Hajime

doi:10.1080/24725625.2020.1818366

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…Histopathological examination showed marked eosinophilic infiltration with marked intimal hyperplasia and vascular lumen narrowing. 11 Watanabe believed that juvenile temporal arteritis was a manifestation of Kimura disease and provided detailed pathological evidence to further demonstrate and clarify his views. 12 …”

Section: Discussionmentioning

confidence: 97%

An Unusual Case of Systemic Lymphadenopathy - Kimura’s Disease

Liu¹,

Liu²,

Xu³

et al. 2023

JIR

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Background Kimura’s disease (KD) is a rare, chronic inflammatory disease. Clinically, subcutaneous nodules of the head and neck are typical manifestations, often accompanied by local lymphadenopathy or salivary gland enlargement, but there is also systemic damage, such as kidney involvement. Due to the lack of specific markers and imaging examination is not specific, it is difficult to clinically diagnose accurately and can be easy to misdiagnose. The treatment of KD is still not standardized and overtreatment can affect the quality of life. Case Presentation The case of a 26-year-old man complaining of chest pain with self-conscious progressive lymphadenopathy after receiving Pfizer BioNTech COVID-19 vaccine for more than 1 month is presented. Eosinophil levels were normal and IgE elevated and the final diagnosis of KD was eventually confirmed by lymph node biopsy, which revealed lymphadenopathy with extensive eosinophilic infiltration in the right neck. Treatment was prednisone combined with methotrexate, resulting in satisfactory control. Conclusion This case demonstrates that that Kimura disease can involve systemic lymphadenopathy, not only in the head and face or regional lymphadenopathy, suggested that KD should be excluded in patients with systemic lymphadenopathy. The current patient’s response to treatment suggested that corticosteroid combined with disease-modifying antirheumatic drugs (DENARDs) was a promising treatment for KD patients with systemic damage. It is worth noting that the mechanism of immunity in the pathogenesis of KD still needs to be further studied.

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Section: Discussionmentioning

confidence: 97%

An Unusual Case of Systemic Lymphadenopathy - Kimura’s Disease

Liu¹,

Liu²,

Xu³

et al. 2023

JIR

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“…In Kimura's disease, the male to female ratio is far more than 10:1 in patients aged <20 years, while the ratio is 2:1 in those aged >40 years. 14 According to a thorough review of JTA (n = 47), 3 the male to female ratio is approximately 10:1 in patients aged <40 years, while the ratio is almost 1:1 in those aged >40 years. This epidemiological similarity may also support that JTA is a manifestation of Kimura's disease.…”

Section: Reference Valuesmentioning

confidence: 99%

“…Many cases of JTA have been reported in Asian countries, but Caucasians can also be affected. [1][2][3] Because JTA occasionally develops with Kimura's disease, whether it is a manifestation of Kimura's disease or a distinct clinicopathological entity has not yet been determined. [1][2][3][4][5] Kimura's disease is also a rare disease that manifests as subcutaneous swelling, often seen on the face and neck.…”

mentioning

confidence: 99%

“…[1][2][3] Because JTA occasionally develops with Kimura's disease, whether it is a manifestation of Kimura's disease or a distinct clinicopathological entity has not yet been determined. [1][2][3][4][5] Kimura's disease is also a rare disease that manifests as subcutaneous swelling, often seen on the face and neck. 6 Massive eosinophilic infiltrations and lymphoid follicle hyperplasia are the characteristic histologic findings.…”

mentioning

confidence: 99%

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Case report: Minimal change nephrotic syndrome in a patient with juvenile temporal arteritis and eosinophilia

Nagao,

Yabe,

Hirai

et al. 2024

Int J of Rheum Dis

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“…Indeed, eosinophilic inflammation should prompt the search for an alternative diagnosis, such as eosinophilic granulomatosis with polyangiitis. In rare cases, temporal arteritis can be attributed to an alternative vasculitis and atypical features on histologic examination are often the first clue ( 54 , 55 ). Neutrophils may have a role in extravascular GCA.…”

Section: Innate Immunity In Gcamentioning

confidence: 99%

Innate and Adaptive Immunity in Giant Cell Arteritis

et al. 2021

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Autoimmune diseases can afflict every organ system, including blood vessels that are critically important for host survival. The most frequent autoimmune vasculitis is giant cell arteritis (GCA), which causes aggressive wall inflammation in medium and large arteries and results in vaso-occlusive wall remodeling. GCA shares with other autoimmune diseases that it occurs in genetically predisposed individuals, that females are at higher risk, and that environmental triggers are suspected to beget the loss of immunological tolerance. GCA has features that distinguish it from other autoimmune diseases and predict the need for tailored diagnostic and therapeutic approaches. At the core of GCA pathology are CD4+ T cells that gain access to the protected tissue niche of the vessel wall, differentiate into cytokine producers, attain tissue residency, and enforce macrophages differentiation into tissue-destructive effector cells. Several signaling pathways have been implicated in initiating and sustaining pathogenic CD4+ T cell function, including the NOTCH1-Jagged1 pathway, the CD28 co-stimulatory pathway, the PD-1/PD-L1 co-inhibitory pathway, and the JAK/STAT signaling pathway. Inadequacy of mechanisms that normally dampen immune responses, such as defective expression of the PD-L1 ligand and malfunction of immunosuppressive CD8+ T regulatory cells are a common theme in GCA immunopathology. Recent studies are providing a string of novel mechanisms that will permit more precise pathogenic modeling and therapeutic targeting in GCA and will fundamentally inform how abnormal immune responses in blood vessels lead to disease.

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Is Kimura’s disease associated with juvenile temporal arteritis? A case report and literature review of all juvenile temporal arteritis cases

Cited by 8 publications

References 25 publications

An Unusual Case of Systemic Lymphadenopathy - Kimura’s Disease

An Unusual Case of Systemic Lymphadenopathy - Kimura’s Disease

Case report: Minimal change nephrotic syndrome in a patient with juvenile temporal arteritis and eosinophilia

Innate and Adaptive Immunity in Giant Cell Arteritis

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