Is itch intensity in atopic dermatitis associated with skin colonization by staphylococcus aureus?

Blicharz, Leszek; Usarek, Paulina; Młynarczyk, G.; Skowroński, Krzysztof; Rudnicka, Lidia; Samochocki, Zbigniew

doi:10.4103/ijd.ijd_136_19

Cited by 13 publications

(8 citation statements)

References 27 publications

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“…Increased Staphylococcus aureus (S. aureus) skin colonization has been observed, especially during AD exacerbations, and there is a correlation between the diversity of the skin microbiome and disease severity [147]. Interestingly, in a study conducted by Blicharz et al, it was found that skin colonization by S. aureus may be one of the factors exacerbating pruritus in AD [148]. Bacterial products, including lipoprotein of the cell wall known as lipoteichoic acid (LTA), might play a role in skin inflammation caused by staphylococci and can act as an agonist for Toll-like receptor 2 (TLR2).…”

Section: Role Of the Microbiotamentioning

confidence: 99%

Pathomechanism of Pruritus in Psoriasis and Atopic Dermatitis: Novel Approaches, Similarities and Differences

Kaczmarska,

Kwiatkowska,

Skrzypek

et al. 2023

IJMS

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Pruritus is defined as an unpleasant sensation that elicits a desire to scratch. Nearly a third of the world’s population may suffer from pruritus during their lifetime. This symptom is widely observed in numerous inflammatory skin diseases—e.g., approximately 70–90% of patients with psoriasis and almost every patient with atopic dermatitis suffer from pruritus. Although the pathogenesis of atopic dermatitis and psoriasis is different, the complex intricacies between several biochemical mediators, enzymes, and pathways seem to play a crucial role in both conditions. Despite the high prevalence of pruritus in the general population, the pathogenesis of this symptom in various conditions remains elusive. This review aims to summarize current knowledge about the pathogenesis of pruritus in psoriasis and atopic dermatitis. Each molecule involved in the pruritic pathway would merit a separate chapter or even an entire book, however, in the current review we have concentrated on some reports which we found crucial in the understanding of pruritus. However, the pathomechanism of pruritus is an extremely complex and intricate process. Moreover, many of these signaling pathways are currently undergoing detailed analysis or are still unexplained. As a result, it is currently difficult to take an objective view of how far we have come in elucidating the pathogenesis of pruritus in the described diseases. Nevertheless, considerable progress has been made in recent years.

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Section: Role Of the Microbiotamentioning

confidence: 99%

Pathomechanism of Pruritus in Psoriasis and Atopic Dermatitis: Novel Approaches, Similarities and Differences

Kaczmarska,

Kwiatkowska,

Skrzypek

et al. 2023

IJMS

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“…Недавно внимание ученых привлекла растущая роль изменения микробиоты кожного покрова в возникновении зуда [33]. Крупномасштабные исследования по изменению микробиоты кожи были отмечены при зудящих кожных заболеваниях, в частности при АтД [25,34,35].…”

Section: микробиота кожи и зуд: есть ли связь?unclassified

Skin Microbiome Composition and Key Factors of its Barrier Function

Murashkin,

Pavlova,

Epishev

et al. 2023

Vopr. sovr. pediatr.

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The skin is the largest organ of the human body, it creates protective barrier between the internal and external environment. Skin barrier damage may result in homeostasis imbalance, inflammation, or bacterial infection. The microbiome plays a crucial role in maintaining normal skin functioning: control of pathogenic diversity of microorganisms, stimulate immune cells, and modulate chronic dermatoses development. There are various mechanisms for restoring skin barrier function. They are associated with the microorganisms’ activity. Thus, skin restoration is an important task included in the general concept of atopic dermatitis management. One of such methods is the skin surface colonization with commensals, so significant role is assigned to the new dermatological drugs. The normalization of the microbiome in affected skin areas with cosmetic care products can significantly affect the result of skin barrier restoration.

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“…[17][18][19][20][21] Secondary infection can also aggravate itch. 22,23 Scabies itch can be highly debilitating and stigmatizing. In scabies, itch is associated with significant sleep problems, where there is strong correlation between the level of itch and disturbed sleep.…”

Section: Complications and Impact Of Scabies Itchmentioning

confidence: 99%

“…acute poststreptococcal glomerulonephritis, acute rheumatic fever, rheumatic heart disease, bacteremia), which are at times associated with high risk of mortality 17–21 . Secondary infection can also aggravate itch 22,23 …”

Section: Scabies Itch: the Clinical Aspectsmentioning

confidence: 99%

Scabies itch: an update on neuroimmune interactions and novel targets

Kim

Hashimoto

Fischer

et al. 2021

Acad Dermatol Venereol

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Frequently described as 'the worst itch' one can ever experience scabies itch is the hallmark of Sarcoptes scabiei mite infestation. Notably, the itchiness often persists for weeks despite scabicides therapy. The mechanism of scabies itch is not yet fully understood, and effective treatment modalities are still missing which can severely affect the quality of life.The aim of this review is to provide an overview of the scope of itch in scabies and highlight candidate mechanisms underlying this itch. We herein discuss scabies itch, with a focus on the nature, candidate underlying mechanisms and treatment options. We also synthesize this information with current understanding of the mechanisms contributing to non-histaminergic itch in other conditions. Itch is a major problem in scabies and can lead to grave consequences. We provide the latest insights on host-mite interaction, secondary microbial infection and neural sensitization with special emphasis on keratinocytes and mast cells to better understand the mechanism of itch in scabies. Also, the most relevant current modalities remaining under investigation that possess promising perspectives for scabies itch (i.e. proteaseactivated receptor-2 (PAR-2) inhibitor, Mas-related G protein-coupled receptor X2 (MRGPRX2) antagonist) are discussed. Greater understanding of these diverse mechanisms may provide a rational basis for the development of improved and targeted approaches to control itch in individuals with scabies.

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Is itch intensity in atopic dermatitis associated with skin colonization by staphylococcus aureus?

Cited by 13 publications

References 27 publications

Pathomechanism of Pruritus in Psoriasis and Atopic Dermatitis: Novel Approaches, Similarities and Differences

Pathomechanism of Pruritus in Psoriasis and Atopic Dermatitis: Novel Approaches, Similarities and Differences

Skin Microbiome Composition and Key Factors of its Barrier Function

Scabies itch: an update on neuroimmune interactions and novel targets

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