Is It Time to Treat Prehypertension?

Association of visceral and total body fat with hypertension and prehypertension in a middle-aged Chinese population

“…Moreover, the ORs for hypertension or prehypertension by increasing PBF or VFI levels that were estimated from the multivariate ordinal logistic models with interaction term of PBF levels by VFI levels have further indicated that the effects of VFI on hypertension and prehypertension are considerably more than those of PBF. Given the high prevalence of prehypertension [6][7][8], we would like to emphasize the clinical importance of identifying prehypertension because it needs to be treated in individuals with serious comorbidities such as diabetes, chronic kidney disease, and coronary artery disease. However, the long-term benefits of treating prehypertension are still unknown [35].…”

“…However, the long-term benefits of treating prehypertension are still unknown [35]. Furthermore, it should be noted that the pathophysiology of elevated risk for cardiovascular events associated with prehypertension is presumed to be the same as that of hypertension [6], which, in this study population, would be similar to obesityassociated hypertension involving the activation of the sympathetic nervous system (by high leptin and low adiponectin levels), renin-angiotensin system leading to the accumulation of large dysfunctional adipocytes, and sodium retention, among other abnormalities [10,36].…”

“…Furthermore, 30% of adults in the general population meet the prehypertension criteria. Prehypertension is regarded as an independent risk factor for hypertension and subsequent cardiovascular events [6][7][8]. Moreover, it is also noted that hypertension is significantly associated with other factors such as age, male gender, BMI, low education level, smoking, positive family history of selected medical conditions, occupation, and parity [9].…”

High Prevalence of Prehypertension and Hypertension in a Working Population in Hungary

“…Data regarding the prevalence of hypertension from one of the worksites have been reported previously. 5 It is estimated that in the general population, up to one in three adults has prehypertension, 6 however, this assumption has not been validated in Hungary before. The objective of this manuscript was to expand our analysis beyond hypertension by addressing the prevalence of prehypertension and the role of increased heart rate (HR) in a substantially larger study population.…”

A study of atenolol and nebivolol in prehypertension

“…angiotensin receptor blockers retard age-related BP increase in pre-hypertensive patients." 6 "Another study revealed that early pharmacological intervention had strong beneficial effects on aortic elasticity in patients with prehypertension." 7 The present study was planned with the objective to evaluate the effect of atenolol and nebivolol in pre-hypertensive patients.…”