Is it possible to predict the presence of colorectal cancer in a blood test? A probabilistic approach method

Rodríguez, José Manuel Navarro; Plazas, Javier Gallego; Rocher, Fernando Borrás; Rico, Rafael Calpena; Maciá, José Antonio Ruiz; Rodenas, Miguel Ángel Morcillo

doi:10.17235/reed.2017.4645/2016

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…Lin et al [2] reported that an elevated PLT count might influence the development of colorectal cancer, and the preoperative PLT count might be a predictive factor of survival in patients with colorectal cancer. Navarro et al [19] showed the presence of a predictive characteristic of colorectal cancer in the blood that can be measured with an interaction index of various blood parameters, such as PLT counts and levels of hemoglobin, fibrinogen, hematocrit, total leukocytes, eosinophils, and neutrophils. The current study showed that patients with negative lymph nodes and venous invasion had significantly lower PLT counts than patients with positive lymph nodes and venous invasion.…”

Section: Discussionmentioning

confidence: 99%

The clinical significance of preoperative plasma fibrinogen levels and platelet counts in resectable colon cancer

Kundaktepe

Papila

2021

World J Surg Onc

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Background and aim Several aspects of the correlation between colon cancer and hemostatic markers are still unknown to many researchers in the field. In this study, we evaluated the association, if any, of preoperative platelet (PLT) counts and plasma fibrinogen levels with postoperative lymph node involvement and venous invasion in colon cancer patients. Methods This study retrospectively included eighty patients with colon cancer (mean age 58.09 years; 37% female 63% male). Results Patients with negative lymph nodes and venous invasion showed a significantly lower PLT count and higher fibrinogen level than their counterparts, i.e., patients with positive lymph nodes (p<0.001, all of them) and venous invasion (p<0.001, all of them). The results also showed a positive association of PLT counts and fibrinogen levels with lymphatic invasion (r=0.670, p<0.001 and r=0.639, p<0.001, respectively) and a positive association of PLT counts and fibrinogen levels with venous invasion (r=0.3988, p<0.001 and r=0.5268, p<0.001, respectively). According to the results of the ROC curve analysis, when the PLT count cutoff was 290/mm3, the sensitivity and specificity were 82% and 86.67%, respectively (AUC = 0.8840, p<0.0001, 95% CI 0.8084–0.9596). When the fibrinogen level cutoff was 310.0 mg/dL, the sensitivity and specificity were 72% and 96.67%, respectively (AUC 0.8790, p <0.0001, 95% CI 0.8067–0.9513). Conclusion The preoperative PLT count and plasma fibrinogen level may be considered key markers to monitor postoperative lymph node involvement and venous invasion in colon cancer patients.

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Section: Discussionmentioning

confidence: 99%

The clinical significance of preoperative plasma fibrinogen levels and platelet counts in resectable colon cancer

Kundaktepe

Papila

2021

World J Surg Onc

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“…Lin et al [4] reported that increased PLT count might play some role in the progress of colorectal cancer and preoperative PLT count might be a prognostic indicator in the colorectal cancer patients. Navarro et al [26] showed that a colorectal cancer predictive character exists in blood which can be quanti ed by an interaction index of several blood parameters including PLT counts, brinogen, total leukocytes, neutrophils, and hemoglobin, hematocrit and eosinophil levels. In our study,…”

Section: Discussionmentioning

confidence: 99%

The Clinical Significance of Preoperative Plasma Fibrinogen Levels and Platelet Count in Resectable Colon Cancer

Kundaktepe

Papila

2020

Preprint

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Background and aims: There is still much unknown about the relationship between colon cancer and markers of hemostasis. İn these study, whether or not preoperative platelet (PLT) counts, plasma fibrinogen levels were associated with postoperative lymph node involvement and venous invasion was evaluated in patients of colon cancer.Methods: Eighty patients (mean age: 58.09 years, 37% females, 63% male) were retrospectively included in this study.Results: PLT and fibrinogen values in patients with lymph node and venous invasion negative colon cancer; were significantly lower than patients with positive lymph node (p<0.001, all of them) and venous invasion (p<0.001, all of them). A positive correlation was found between the venous invasion and lymphatic involvement with PLT count and plasma fibrinogen levels (r=0.640, p<0.001; r=0.810, p<0.001, respectively).Conclusion: It was concluded that preoperative PLT count and plasma fibrinogen levels may be useful marker for monitoring postoperative lymph node involvement and venous invasion in patients with colon cancer.

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“…Malignant tumour cells secrete VEGF, tissue factor (TF), cancer procoagulant (CP) and tumour necrosis factor (TNF) leading to a hypercoagulable state of blood and increased plasma FIB levels [11]. FIB forms fibronectin through a series of reactions and acts as a scaffold for the growth, infiltration and metastasis of malignant tumour cells [4] [12]. Palumbo [13] found that the incidence of metastasis was significantly reduced in FIB-deficient mice, but primary tumour growth was not affected.…”

Section: Fib and Colorectal Cancermentioning

confidence: 99%

Recent Advances in Fibrinogen Research in Colorectal Cancer

Jiang¹,

Wang²,

Yu³

2023

JBM

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Colorectal Cancer (CRC) is a common malignant tumour of the gastrointestinal tract in China, with increasing morbidity and mortality rates year by year. Most patients are in the middle and late stage when diagnosed, and its high mortality and poor prognosis have seriously threatened the health and life. Fibrinogen (FIB) is mainly used as a coagulation factor in the body to participate in the process of coagulation and haemostasis, and is the main protein in the coagulation process. In recent years, studies at home and abroad have shown that FIB levels correlate with the diagnosis, outcome prediction and prognosis of CRC, and some of the findings are still controversial. This article aims to review the related research and new progress of the relationship between FIB and CRC in recent years.

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Is it possible to predict the presence of colorectal cancer in a blood test? A probabilistic approach method

Cited by 5 publications

References 22 publications

The clinical significance of preoperative plasma fibrinogen levels and platelet counts in resectable colon cancer

The clinical significance of preoperative plasma fibrinogen levels and platelet counts in resectable colon cancer

The Clinical Significance of Preoperative Plasma Fibrinogen Levels and Platelet Count in Resectable Colon Cancer

Recent Advances in Fibrinogen Research in Colorectal Cancer

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