Is it possible to identify dengue in children on the basis of Ministry of Health criteria for suspected dengue cases?

Rodrigues, Marisa B. P.; Freire, Heliane B.M.; Corrêa, Paulo Roberto Lopes; Mendonça, Marislaine Lumena de; Silva, Maria Regina I.; França, Elizabeth

doi:10.2223/1341

Cited by 15 publications

(9 citation statements)

References 11 publications

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“…Accordingly, none of these criteria are alone, in conjunction with fever, pathognomonic of dengue. The same observation was made by studies in Colombia, Brazil, Peru and Thailand [9]–[11], [28]. We also analyzed whether the inclusion of increasing numbers of criteria in the definition improves the diagnostic utility of the case definitions by creating diagnostic models based on each case definition.…”

Section: Discussionmentioning

confidence: 75%

Evaluation of the Diagnostic Utility of the Traditional and Revised WHO Dengue Case Definitions

et al. 2013

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Dengue, a mosquito-borne viral illness, is a major public health problem worldwide, and its incidence continues to increase. In 2009, the World Health Organization published guidelines that included a revision of the dengue case definition. Compared to the traditional definition, the revised case definition relies more on signs than on symptoms, making it more applicable to young children. We evaluated the diagnostic utility of both case definitions in two studies of pediatric dengue in Managua, Nicaragua. In a community-based cohort study, we included data from 3,407 suspected dengue cases, of which 476 were laboratory-confirmed. In the second study, we collected information from 1,160 participants recruited at the national pediatric reference hospital (723 laboratory-confirmed). In the cohort study, the traditional definition had 89.3% sensitivity and 43.1% specificity, while the revised definition yielded similar sensitivity (86.6%) and higher specificity (55.2%, p<0.001). In the hospital study, the traditional case definition yielded 96.7% sensitivity and 22.0% specificity, whereas the revised case definition had higher sensitivity (99.3%, p<0.001) but lower specificity (8.5%, p<0.001). We then evaluated the performance of two diagnostic models based on the signs/symptoms included in each definition by analyzing the effect of increasing numbers of signs/symptoms on the sensitivity and specificity of case capture. Receiver operating characteristic analysis showed a slightly better performance for the revised model in both studies. Interestingly, despite containing less symptoms that cannot be readily expressed by children aged less than 4 years, the revised definition did not perform better in this age group. Overall, our results indicate that both case definitions have similar capacity to diagnose dengue. Owing to their high sensitivity and low specificity, they should be primarily used for screening purposes. However, in a primary care setting, neither of the case definitions performed well as a screening test in younger children.

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Section: Discussionmentioning

confidence: 75%

Evaluation of the Diagnostic Utility of the Traditional and Revised WHO Dengue Case Definitions

et al. 2013

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“…The difficulty encountered in diagnosing dengue in children is caused by many factors, such as the large numbers of febrile diseases that affect the pediatric population and the fact that children do not present specific signals for dengue [ 25 , 26 ]. Therefore, the characterization of dengue in the pediatric population is a very important topic, emphasizing the importance of establishing new diagnostic criteria for this population group, since laboratory tests are not always available for diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children

Martins

Pereira

Oliart-Guzmán

et al. 2014

Interdisciplinary Perspectives on Infectious Diseases

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This study aimed to evaluate the prevalence of serum IgG dengue in children in an Amazonian population, to assess the seroconversion rate in 12 months, and to estimate how many seropositive children had a prior clinical diagnosis of dengue. We conducted a population-based study between 2010 and 2011, with children aged 6 months to 12 years that were living in the urban area of a small town in the Brazilian Amazon. The prevalence of IgG antibodies against dengue antigens was determined by indirect ELISA technique, and seronegative children were reexamined after 12 months to determine seroconversion rates. Results showed seroprevalence of IgG antibodies against dengue type of 2.9%, with no significant association between age, race, and sex. In seropositive children, only 8.4% had received a clinical diagnosis of dengue, and the ratio of clinically diagnosed cases and subclinical cases was 1 : 11. The seroconversion rate between 2010 and 2011 was 1.4% (CI 3.8% to 35.1%). The seroprevalence of dengue in this pediatric population was low, and the vast majority of cases were not clinically detected, suggesting a difficulty in making the clinical diagnosis in children and a high frequency of asymptomatic infections.

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“…Authors have studied the importance of early diagnosis of and correct treatment for dengue fever and malaria in endemic regions. The prevalence of dengue in children living in areas in the N Region [141,142], CO Region [145] and SE Region [147] have led to a disruption of routine health services, demanding further efforts towards providing technical training to health professionals working on the frontline of dengue treatment in children's patient care. As for malaria, researches had investigated children and adolescents who live in the N region [151,152].…”

Section: Grandjean Et Almentioning

confidence: 99%

“…Our data survey had only 4 (30%) studies dedicated to the risk factors to children exposed to the dengue virus [141,142,145,147]. The researches were conducted in the same Brazilian areas where today there are more cases of the zika virus and chikungunya caused by Aedes aegpty [179].…”

Section: Social -Sanitation and Socio-environmental Factorsmentioning

confidence: 99%

Children's Environment in Brazil: From Domestic (Indoor) to Regional Threats

Perlroth¹,

Branco²

2017

IJPCC

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Is it possible to identify dengue in children on the basis of Ministry of Health criteria for suspected dengue cases?

Cited by 15 publications

References 11 publications

Evaluation of the Diagnostic Utility of the Traditional and Revised WHO Dengue Case Definitions

Evaluation of the Diagnostic Utility of the Traditional and Revised WHO Dengue Case Definitions

Seroprevalence and Seroconversion of Dengue and Implications for Clinical Diagnosis in Amazonian Children

Children's Environment in Brazil: From Domestic (Indoor) to Regional Threats

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