Is it merely a myth that alcoholic beverages such as red wine can be cardioprotective?

Stockley, Creina S.

doi:10.1002/jsfa.5696

Cited by 13 publications

(8 citation statements)

References 102 publications

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“…Benefits of moderate alcohol consumption include a reduction in the risk of developing coronary heart disease (CHD), congestive heart failure, intermittent claudication, and myocardial infarction (MI) (Stockley, ). There is a 20 to 45% reduction in the risk of developing CHD, which is causally related to moderate alcohol consumption compared with abstention (Rimm et al., ).…”

Section: Cardioprotection Mechanisms Of Alcoholmentioning

confidence: 99%

The Good, the Bad, and the Ugly with Alcohol Use and Abuse on the Heart

Walker

Cousins

Umoh

et al. 2013

Alcoholism Clin & Exp Res

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Since its advent, alcohol has been utilized throughout history socially, for rituals, worship, for its therapeutic, antibacterial, and analgesic properties. In moderation, alcohol consumption and its use are generally viewed as clinically beneficial. Excessive alcohol consumption on the other hand has been recognized as having several adverse implications. Excessive use increases the risk of liver and heart disease, metabolic disturbances, nutritional deficiencies, certain cancers, brain damage, dementia, neuropathy, as well as other facets of morbidity and mortality. This review targets the sequelae of alcohol consumption on the heart, specifically on myocardial contractility, calcium channel signaling, and intracellular signaling pathways. With the incidence of alcohol-induced cardiac abnormalities being higher than previously thought, it is of increasing importance to elucidate the mechanisms behind them. Here the cardiac effects of alcohol were not discussed in isolation but in conjunction with other important factors, such as HDL and LDL levels and vascular dilatory influences. We explore these mechanisms, in particular, the oxidative stress as the major contributor, as well as pathways that may prove to be cardioprotective. As such, we demonstrate the involvement of Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2/ NRF2) as well as Akt, that act as regulators of oxidative balance during oxidative stress responses. Thus, alcohol consumption may confer a cardioprotective effect when used in moderation through an Akt/NRF2-dependent mechanism.

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Section: Cardioprotection Mechanisms Of Alcoholmentioning

confidence: 99%

The Good, the Bad, and the Ugly with Alcohol Use and Abuse on the Heart

Walker

Cousins

Umoh

et al. 2013

Alcoholism Clin & Exp Res

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“…This sentence indicates that both pattern and amount and wine intake are relevant. Episodic heavy (or binge) drinking is considered more harmful that consumption of less than or equal to 2 drinks per day, but more than 0, for men, and less than or equal to 1 drink per day, but more than 0, for women (Stockley, 2012;Chiva-Blanch et al, 2013b). Lastly, red wine polyphenols, independently from ethanol, reduced the pro-oxidant effects of a fat-rich meal, thus reducing the postprandial susceptibility of LDL to oxidation (Natella et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effects of moderate red wine consumption: Polyphenols vs. ethanol

Varoni¹

2014

JAB

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This article appeared in a journal published by Elsevier. The attached copy is furnished to the author for internal non-commercial research and education use, including for instruction at the authors institution and sharing with colleagues.Other uses, including reproduction and distribution, or selling or licensing copies, or posting to personal, institutional or third party websites are prohibited.

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“…These phenolic compounds identified so far include polyphenols such as resveratrol, phenolic acids, flavonoids and anthocyanins [17]. They all possess potent antioxidant properties and have been shown to inhibit oxidation of human LDL and platelet aggregation, these compounds has also been shown to have a range of additional cardioprotective and vasoprotective properties including scavenging reactive oxygen and nitrogen species, increasing HDLs, antiatherosclerotic, antiarrhythmic, and enhancing vasorelaxation actions [16,18,19]. Dose the Chinese yellow wine play the same effect as the red wine?…”

Section: Identification and Characterization Of Vecsmentioning

confidence: 99%

Chinese Yellow Wine Could Inhibit Production of Matrixmetalloproteinase-2 Induced by Homocysteine in Cultured Rat Vascular Endothelial Cells

Guo¹,

Meng²,

Zhou³

2015

J Nutr Food Sci

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Background: The effects of Chinese yellow wine on the production of homocysteine (Hcy) induced intracellular MMP-2 in cultured rats vascular endothelial cells (VECs) has not been investigated. Methods: Isolation, cultivation, purification and identification of vascular endothelial cells of rat thoracic aorta in vitro were conducted. The VECs in passages 3 to 4 were used in all studies. HCY was used to induce VECs to over expressing MMP-2. Cells were divided into 5 groups: Control, Hcy, Hcy+yellow wine, Hcy+red wine, Hcy+ethanol and the cells were given different treatment for 48 h. The mRNA expression of MMP-2 was detected by FQ-PCR. The western blotting and gelatin zymography were applied to test the protein levels and the enzymatic activity of MMP-2. Results: Hcy could significantly increase the expression and activity of MMP-2 compared with the control group, and could reach the maximum at 500 µ mol/L, cultured for 48 h. Compared with those in Hcy group, the expression and activity of MMP-2 in yellow wine and red wine groups was significantly decreased. No significant difference was shown as between the ethanol group and the Hcy group and no significant discrepancy between the yellow wine and red wine group was found. Conclusions: The result suggest that Hcy promotes the expression and activity of MMP-2, which may play an important role in pathogenesis of atherosclerosis (AS). Treatment with yellow wine or red wine decreases Hcy-induced MMP-2 production in VECs. The attenuation of MMP-2 activation by yellow wine and red wine might contribute to their beneficial effects on the cardiovascular system.

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Is it merely a myth that alcoholic beverages such as red wine can be cardioprotective?

Cited by 13 publications

References 102 publications

The Good, the Bad, and the Ugly with Alcohol Use and Abuse on the Heart

The Good, the Bad, and the Ugly with Alcohol Use and Abuse on the Heart

Cardioprotective effects of moderate red wine consumption: Polyphenols vs. ethanol

Chinese Yellow Wine Could Inhibit Production of Matrixmetalloproteinase-2 Induced by Homocysteine in Cultured Rat Vascular Endothelial Cells

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