Is it feasible to diagnose germ-cell tumors by fine-needle aspiration biopsy?

Akhtar, Mohammed; Dayel, Fouad Al

doi:10.1002/(sici)1097-0339(199701)16:1<72::aid-dc16>3.0.co;2-8

Cited by 36 publications

(31 citation statements)

References 13 publications

(47 reference statements)

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“…The anaplastic-looking cells in UDC may be reminiscent of RS cells, but RS cells always have some cytoplasm, and the brisk apoptosis seen in UDC is not seen in Hodgkin's disease. 8 Although the nuclear features of germ-cell tumors and UDC were found to overlap, the glandular and papillary formations, cytoplasmic vacuoles, and hyaline globules seen in YST 21,22 are not seen in UDC. In a situation where the cytologist is interpreting the smear without clinical details or when metastasis to neck node is a primary mode of presentation, these are helpful features.…”

Section: Discussionmentioning

confidence: 97%

Cytological evaluation of head and neck tumors in children—A pattern analysis

et al. 2006

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A total of 135 pediatric head and neck tumors diagnosed in our institute were reviewed with a view to elucidate the overall cytological patterns and analyze the important cytological features. Ninety-four tumors (69.6%) were aspirated for a primary diagnosis, and in 41 (30.4%) cases, fine-needle aspiration cytology was performed to document relapse, recurrence or a metastasis. Among the 94 tumors aspirated for a primary diagnosis, 66 cases (70.2%) were accurately diagnosed, in 22 cases (23.4%) a broad working diagnosis was offered, and 6 cases (6.4%) were misdiagnosed. The accuracy rate was higher (79.3%) when relapse-recurrent and metastatic tumors were included. The smears were broadly divided into six patterns, viz. round cell, epithelial, anaplastic, giant cell, mixed inflammatory, and spindle cell patterns. The round cell pattern was the most frequent one encountered in this group. The cytological features that stood the test of variability were lymphoglandular bodies and a noncohesive cell population in hematolymphoid malignancies, pale chromatin and cytoplasmic vacuoles in primitive neuroectodermal tumor/Ewing's sarcoma (PNET/ES), neuropil and rosettes in neuroblastoma, and plasmacytoid rhabdomyoblasts in rhabdomyosarcoma. A fairly good accuracy was seen in the diagnosis of metastatic undifferentiated carcinoma and anaplastic lymphoma, but the giant-cell and spindle-cell tumors continued to pose a problem in diagnosis. Ancillary techniques such as immunocytochemistry and electron microscopy applied in limited cases helped evaluate Langerhans cell histiocytosis, alveolar rhabdomyosarcoma, and the PNET/ES family of tumors.

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Section: Discussionmentioning

confidence: 97%

Cytological evaluation of head and neck tumors in children—A pattern analysis

et al. 2006

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“…124 Intraoperative imprint cytology may aid in the correct diagnosis of germ cell tumors as they allow for more thorough sampling of the tumor than a single frozen section. 126,127 The nuclear membranes are irregular with coarsely clumped to vesicular chromatin and one or two, large, eosinophilic nucleoli. 68 When positive, APW specimens are typically cellular with large tumor cells that display scant to moderate amounts of indistinct, fragile, vacuolated cytoplasm.…”

Section: Germ Cell Tumorsmentioning

confidence: 99%

“…125 Dysgerminoma Dysgerminomas are the most common malignant germ cell tumor of the ovary, and comprise 1-2% of all malignant ovarian tumors. [126][127][128] While sarcoid-like granulomas and mature lymphocytes may be observed in surgical pathology specimens and in FNA specimens of dysgerminomas, these may not be observed in positive APW. 126,127 The nuclear membranes are irregular with coarsely clumped to vesicular chromatin and one or two, large, eosinophilic nucleoli.…”

Section: Germ Cell Tumorsmentioning

confidence: 99%

“…92,[126][127][128]130 The borders of the three-dimensional groups are smooth, and cells will be overlapping. 92,[126][127][128]130 Intra-and extracellular periodic acid Schiff positive hyaline globules, and a hyaline basement membrane material may be observed, but overt Schiller-Duval bodies are usually not identified in cytology samples. 92,[126][127][128]130 Intra-and extracellular periodic acid Schiff positive hyaline globules, and a hyaline basement membrane material may be observed, but overt Schiller-Duval bodies are usually not identified in cytology samples.…”

Section: Yolk Sac Tumorsmentioning

confidence: 99%

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Abdominopelvic washings in gynecologic pathology: A comprehensive review

Schulte

Lastra

2016

Diagnostic Cytopathology

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Abdominopelvic washings (APW) performed during gynecologic surgeries have become a common specimen evaluated by cytopathologists. Their role in staging of female genital tract tumors has changed significantly since they were first described, and continue to evolve. The ability of these washings to detect microscopic disease, even in the absence of gross disease, warrants the critical role that these washings play in the staging of certain female gynecologic tract tumors, allowing for optimal staging and subsequent treatment of the patient. Irrespective of the underlying pathology, the gamut of cytomorphologic findings that may be observed in APW is extensive, and ranges from benign lesions that may act as mimickers of malignancy, to both common and rare malignancies. This review discusses the changing role of APW in the staging of gynecologic tumors, and highlights the salient cytomorphologic features of these lesions, with emphasis in their correct identification, including cautionary notes to avoid over or misinterpretation. Diagn. Cytopathol. 2016;44:1039-1057. © 2016 Wiley Periodicals, Inc.

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“…39,78,81,90 This is because of the marked morphologic overlaps of these tumors. Moreover, it is not uncommon to find a mixture of various germ cell tumor components within one lesion.…”

Section: Key Features Of Yolk Sac Tumormentioning

confidence: 99%

Mediastinum

Ng¹

2008

Comprehensive Cytopathology

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Is it feasible to diagnose germ-cell tumors by fine-needle aspiration biopsy?

Cited by 36 publications

References 13 publications

Cytological evaluation of head and neck tumors in children—A pattern analysis

Cytological evaluation of head and neck tumors in children—A pattern analysis

Abdominopelvic washings in gynecologic pathology: A comprehensive review

Mediastinum

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