The question of why some people reject scientific evidence has occupied researchers for some time. While most studies examine reasons for specific science denial (e.g., climate change denial), in this paper we examine whether a general skepticism towards science is related to the rejection of specific scientific facts. Therefore, we develop and validate a new scale measuring people’s general science skepticism in two studies with German samples. In Study 1 (N = 185), we find science skepticism to be a two-factorial construct, with one factor including people’s skepticism towards motives and methods, and the other factor comprising skepticism towards independence and completeness. In a preregistered second study with a representative sample (N = 1029) we were able to confirm these results. Moreover, general science skepticism was positively related to the rejection of scientific statements from eight different subject areas and related to variables related to science and politics (e.g., trust in science, conspiracy mentality, and political orientation) known to be involved in science denial. In sum, the present work makes a new contribution in understanding the reasons for general science skepticism and specific denial.