Is irritable bowel syndrome more common in patients presenting with bacterial gastroenteritis? A community-based, case-control study

Parry, Sally D; Stansfield, Rosamund; Jelley, Diana; Gregory, W. Larry; Phillips, Elizabeth; Barton, J R; Welfare, Mark

doi:10.1111/j.1572-0241.2003.07242.x

Cited by 59 publications

(16 citation statements)

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“…The pathogen also plays a role because the more severe infections, such as Campylobacter and Salmonella, are 10 and 50 times more likely to lead to consultation and investigation than gastroenteritis because of rotavirus and small round structured viruses, which are often mild and shortlived (10). Finally, there are patient features, which is the subject of the paper by Parry et al from Newcastle, United Kingdom, published in this issue of the journal (11).…”

Section: Estimating the Importance Of Infection In Ibsmentioning

confidence: 99%

“…The existence of ANAs specific for PBC is in contrast to autoimmune hepatitis type 1, a disease also characterized by the presence of ANA (alone or in association with antismooth muscle antibody) because in autoimmune hepatitis type 1, no disease-specific ANA has yet been identified. The PBC-specific ANAs give two distinct immunofluorescence patterns: the perinuclear (rimlike) (10) and the multiple nuclear dot pattern (11). Molecular targets associated with these two immunofluorescence appearances have been identified.…”

Section: Positive Markers In Ama-negative Pbcmentioning

confidence: 99%

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Estimating the importance of infection in IBS

Spiller¹

2003

The American Journal of Gastroenterology

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Section: Estimating the Importance Of Infection In Ibsmentioning

confidence: 99%

Section: Positive Markers In Ama-negative Pbcmentioning

confidence: 99%

Estimating the importance of infection in IBS

Spiller¹

2003

The American Journal of Gastroenterology

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“…Military personnel with IBS prior to deployment were not excluded, and there is no way to account for patients with gastroenteritis who did not consult for gastroenteritis during deployment. This is an important point because subjects who consult a physician for gastroenteritis are more likely to have IBS [15]. Healthseeking behavior is more common in IBS patients than in control patients.…”

mentioning

confidence: 99%

Deployment-Associated Functional Gastrointestinal Disorders: Do We Know the Etiology?

Tuteja

2011

Dig Dis Sci

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Functional gastrointestinal disorders (FGD) are a collection of symptoms with no known anatomical or biochemical abnormality [1]. Irritable bowel syndrome (IBS) and dyspepsia are two of the most common types of FGD. The etiology of these disorders is unknown, but speculated mechanisms include altered gastrointestinal motility, visceral hypersensitivity, aberrant brain-gut interaction, food intake, and psychological factors, perhaps with a genetic predisposition [2]. Acute gastrointestinal infection can precipitate or exacerbate the clinical expression of IBS and dyspepsia [3,4]. Various studies in non-military populations have demonstrated the onset of IBS after gastroenteritis. This type of IBS is known as post-infectious IBS (PI-IBS). The current study makes an association between infective gastroenteritis and subsequent development of FGD in military personnel.Porter and colleagues conducted a retrospective casecontrol study to determine whether self-reported diarrhea and/or vomiting and psychological stress during deployment were associated with increased risk of FGD in active-duty military personnel during their first deployment to Iraq and Afghanistan from 2008 to 2009 [5]. Using active-duty military medical encounter data from the Defense Medical Surveillance System, they identified 129 cases (constipation = 67, dyspepsia = 15, IBS = 22, overlapping syndrome = 25) and 396 controls of FGD using ICD-9 codes.

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Section: Irritable Bowel Syndrome (Ibs) and Its Relation To Blastocysmentioning

confidence: 99%

“…There has been increasing evidence suggesting that low grade transient or chronic inflammation, immunological alterations, or increased epithelial permeability in the intestinal mucosa may be of significance in certain subgroups of IBS patients (Collins et al, 2001; Simren, 2007, 2010; Piche et al, 12 2009) . These studies have estimated that 3.7 -36% of patients develop IBS after an episode of infectious diarrhoea (Abrahamsson et al, 2008; Simren, 2007, 2010;Parry et al, 2003).In the past decade, there has been an increase in literature associating blastocystosis and IBS. The two key reasons being that there appears to be a higher infection rate with Blastocystis in IBS as compared to non-IBS patient controls and that both disorders cause similar nonspecific gastrointestinal signs .…”

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confidence: 99%

Investigating the suitability of dogs and pigs as animal models for blastocystosis

Wang¹

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Blastocystis is an ubiquitous intestinal protozoon with a controversial pathogenesis and can colonise a wide range of species including humans, mammals, birds and reptiles. In the literature these species are collectively referred to as "Blastocystis", and that will be the convention throughout this document as well. In humans, it has been linked with non-specific gastrointestinal signs, non-gastrointestinal signs such as urticaria and recently irritable bowel syndrome. Major hurdles to determining the clinical significance/pathogenesis of Blastocystis are diagnostic limitations as it is a morphologically and genetically diverse organism, poor understanding of host-parasite relationship and the lack of a representative model to fulfil Koch's postulates.The principal aim of the project was identifying a suitable candidate for modelling human blastocystosis. This was defined as being a natural host of Blastocystis, meaning that the species had a high prevalence of Blastocystis infection with a predominant host-adapted subtype/s (ST) and the ability to harbour STs in common with humans. Once a candidate was identified, host/parasite interactions (e.g. intestinal location and pathology of Blastocystis, mucosal immune response) would be characterised to determine if this was comparable to the human infection.Dogs were identified as promising candidates as, in Brisbane, Queensland they have been shown to have a high Blastocystis prevalence and can harbour similar STs as in-contact humans. We utilised Polymerase chain reaction (PCR) to investigate the molecular epidemiology of Blastocystis in dogs in different geographical regions. We found a prevalence of 2.5%, 1.3% and 24% in dogs from Brisbane, a Cambodian village and stray dogs from India respectively. Stray dogs in India carried a diverse range of STs including 1, 4, 5 and 6, while dogs from Brisbane and Cambodia only carried ST1 and ST2 respectively. These differences in Indian dogs compared to the Brisbane/Cambodia dogs could reflect a closer proximity of the dogs to humans and other animals and their faeces. We concluded that dogs are unlikely natural hosts for Blastocystis but rather are transiently and opportunistically infected with a diversity of STs.iii Blastocystis is commonly reported in pigs, with most harbouring ST5 or ST1 and zoonotic transmission of ST5 from pigs has been proposed, therefore they were chosen as the next candidate. We studied the molecular epidemiology of pigs in two different geographic/environmental settings and also if they were zoonotic reservoirs by testing incontact humans for Blastocystis. Utilising PCR, it was found that Blastocystis prevalence in pigs from Southeast Queensland (SEQ) intensive piggeries and a Cambodian village was 76.7% and 45.2%, respectively, with all positive pigs harbouring ST5. 7.1% of pigs harboured ST1 and/or ST3 in addition to ST5, which are the two most common STs in humans. A minority (13.9%) of SEQ piggery staff harboured ST5, which is otherwise rare in humans, indicating possible zoonotic/r...

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Is irritable bowel syndrome more common in patients presenting with bacterial gastroenteritis? A community-based, case-control study

Abstract: IBS is more frequent before diagnosis in people with bacterial gastroenteritis presenting to their primary care physician than in community controls. Studies that examine the rate of IBS after bacterial gastroenteritis need to carefully exclude people with prior IBS in a systematic way.

Cited by 59 publications

References 16 publications

Estimating the importance of infection in IBS

Estimating the importance of infection in IBS

Deployment-Associated Functional Gastrointestinal Disorders: Do We Know the Etiology?

Investigating the suitability of dogs and pigs as animal models for blastocystosis

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