“…Other known severe complications not encountered in the PANFIRE-2 study included portal vein thrombosis, bile leak, gastrointestinal tract perforations, etc. 26 , 29 More recent data from a meta-analysis that evaluated the safety and efficacy of IRE for treating LAPC showed that major complication rates were approximately 17%, 32 with the authors concluding that IRE is a relatively effective and safe treatment method. Nevertheless, because of the potential for complications, the selection of patients who will benefit from treatment with IRE is of utmost importance.…”