Is iron treatment beneficial in, iron-deficient but non-anaemic (IDNA) endurance athletes? A systematic review and meta-analysis

Burden, Richard; Morton, Katie; Richards, Toby; Whyte, Gregory; Pedlar, Charles R.

doi:10.1136/bjsports-2014-093624

Cited by 86 publications

(90 citation statements)

References 63 publications

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“…Other studies claim that ID can induce muscle and hormonal dysfunction and predispose to infection [27]. Recently, Burden et al [28] found that iron supplementation has a positive effect on aerobic capacity (VO 2 max) . In other studies, iron-supplemented subjects without anemia showed improved performance and/or VO 2 max [12].…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Iron Deficiency and Iron Deficiency Anemia in Strenuously Training Male Army Recruits

Epstein

Borohovitz²,

Merdler³

et al. 2018

Acta Haematol

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Objectives: The objectives of our study were to determine the effect of strenuous physical training on the prevalence of iron deficiency anemia (IDA), iron deficiency (ID) with normal hemoglobin (Hb), and anemia without ID. Methods: Our study was a prospective observational study. We followed 115 healthy male recruits in the Israel Defense Forces elite units during 15 months of training. Blood samples were collected at recruitment and at 6-, 9- and 15-month follow-ups. Results: Upon recruitment, anemia (Hb < 14 g/dL), ID, and ID anemia (IDA) were diagnosed in 28, 31, and 9% of individuals, respectively. Sixty-three subjects (54%) were followed for 6 months; 9 of them (14%) developed new-onset IDA. Among them, the prevalence of anemia rose from 19 to 52%, and ID from 33 to 35%. At the 15-month follow-up, 29% had developed new-onset IDA and 65% showed evidence of ID. Conclusion: We report a high prevalence of anemia, ID, and IDA among young healthy males participating in prolonged strenuous training programs. These findings can be partly explained by the physiological changes associated with strenuous physical activity. Further investigations aiming to develop specific diagnostic guidelines for this unique population are warranted.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Iron Deficiency and Iron Deficiency Anemia in Strenuously Training Male Army Recruits

Epstein

Borohovitz²,

Merdler³

et al. 2018

Acta Haematol

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“…Iron deficiency anaemia is caused by insufficient consumption of iron (or insufficient absorption of iron) and is a decrease in red blood cells (RBCs) or haemoglobin, leading to symptoms such as tiredness and fatigue; weakness, shortness of breath and reduced exercise tolerance (Longo and Camaschella, 2015). Iron deficiency without anaemia has also been shown to reduce endurance capacity, increase energy expenditure and impair adaptation to endurance exercise in females experiencing tissue depletion (Burden et al, 2015).Calcium also have significant effect on growth and development insufficient dietary calcium have negative impact on health and increase the risk of diseases such as osteoporosis (Kin et al, 2007;Morris et al, 2008). Zinc acts as a cofactor of various enzymes involved in macronutrient metabolism and cell replication (Soetan et al, 2010;Arinola, 2008).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Micronutrients in Fenugreek (Trigonella foenum-graecum L.): A Viable Alternative for Micronutrient Supplementation

Pant¹,

Tewari²,

Dhoundiyal³

et al. 2018

Int.J.Curr.Microbiol.App.Sci

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Journal homepage: http://www.ijcmas.com Dietary antioxidants (total ascorbate, α-tocopherol and total carotenoids) and micronutrient (iron, calcium, zinc, copper and manganese) content of 25 fenugreek (Trigonella foenum graecum L.) genotypes were evaluated under the present investigation. Higher α-tocopherol and total carotenoid content i.e., 43.080±1.542 mg α-tocopherol/100 g dry wt. and 4.890±0.047 g carotenoids/100 g dry wt. was observed in RMt-305. The genotype RMt-143 showed highest iron, calcium and manganese content i.e., 184.11±1.639, 781.20±4.790 and 25.65±0.695 µg/g dry wt., respectively. Total ascorbate content within fenugreek genotypes under investigation showed a positive correlation with α-tocopherol and total carotenoid content (i.e., 0.114 and 0.061, respectively). It also showed a significant (p≤0.05) positive correlation with manganese (0.298) and iron content (0.062) among the genotypes. α-tocopherol content within fenugreek genotypes also showed a significant (p≤0.01) positive correlation (0.328) with total carotenoid content another important lipid-soluble antioxidant. The iron content within the fenugreek genotypes showed a significant (p≤0.01) positive correlation with other micronutrients viz., calcium, zinc and manganese (i.e., 0.408, 0.502 and 0.299, respectively). A positive correlation was also observed between iron and total ascorbate, α-tocopherol content (i.e., 0.062 and 0.213, respectively) within the genotypes. Similarly other mineral elements viz., calcium, zinc, copper and manganese, respectively also showed a positive correlation with each other in general. The findings of the present investigation clearly show significant variation in dietary antioxidants and micronutrients among the fenugreek genotypes under investigation. Thus the genotypes with higher dietary antioxidants and micronutrient content viz., RMt-305, Pant ragini, RMt-143, Pusa early bunching, IC-066843, GM-2 and HM-355 could be utilized as a valuable source of dietary micronutrients and may serve as potential functional food to combact micronutrient malnutrition along with other favourable health promoting affect. K e y w o r d sAscorbate, α-Tocopherol, Carotenoid, Dietary antioxidants, Micronutrients

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“…Further research is needed to describe this issue and to understand its implications. Interventions to support female athletes such as iron therapy,6 and an increased awareness of HMB among sports medicine professionals could have far reaching benefits for the female athlete.…”

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confidence: 99%

The prevalence and impact of heavy menstrual bleeding among athletes and mass start runners of the 2015 London Marathon

et al. 2015

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Is iron treatment beneficial in, iron-deficient but non-anaemic (IDNA) endurance athletes? A systematic review and meta-analysis

Abstract: These results indicate iron treatments improve the iron status and aerobic capacity of iron deficient non-anaemic endurance athletes.

Cited by 86 publications

References 63 publications

Prevalence of Iron Deficiency and Iron Deficiency Anemia in Strenuously Training Male Army Recruits

Prevalence of Iron Deficiency and Iron Deficiency Anemia in Strenuously Training Male Army Recruits

Evaluation of Micronutrients in Fenugreek (Trigonella foenum-graecum L.): A Viable Alternative for Micronutrient Supplementation

The prevalence and impact of heavy menstrual bleeding among athletes and mass start runners of the 2015 London Marathon

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