Is intermittent claudication improved by percutaneous transluminal angioplasty? A randomized controlled trial

Whyman, M. R.; Fowkes, F. G. R.; Kerracher, E.M.G.; Gillespie, Ian; Lee, A.J.; Housley, E.; Ruckley, C. V.

doi:10.1016/s0741-5214(97)70052-1

Cited by 162 publications

(105 citation statements)

References 14 publications

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“…9 Others found no difference in health status between peripheral balloon angioplasty and a medical therapy. 10 In the longest reported follow-up (mean, 9.3 years), no difference in health status existed among 77 patients who underwent peripheral balloon angioplasty. 11 The Assessment of Lower Extremity Revascularization Outcomes (ALEVE) study was designed explicitly to quan-tify the health status recovery (symptoms, function, and quality of life) of individuals undergoing modern-day PER.…”

Section: Editorial P 550 Clinical Perspective P 575mentioning

confidence: 92%

Quantifying Improvement in Symptoms, Functioning, and Quality of Life After Peripheral Endovascular Revascularization

et al. 2007

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Background— Patients with peripheral arterial disease often undergo peripheral endovascular revascularization (PER) to alleviate symptoms. Despite the growth of PER, little information exists quantifying the health status benefits after the procedure. Methods and Results— From February 2001 to August 2004, 477 consecutive patients underwent PER for symptomatic peripheral arterial disease. Of these, 300 consented to participate in a longitudinal follow-up study of their health status. Health status was quantified with the disease-specific Peripheral Artery Questionnaire and the generic Short Form-12 and the EuroQol 5 Dimensions (EQ5D)questionnaire. Scores range from 0 to 100; higher scores represent fewer symptoms and better health status. The average age of the cohort was 68±11 years (mean±SD); 186 (62%) were male, 288 (96%) were white, and 118 (39%) were diabetic. Clinical follow-up was attained in 99% of patients; health status assessments were made in 86%. Mean Peripheral Artery Questionnaire summary scores improved significantly after revascularization from 31±19 to 62±27 at 1 year ( P <0.0001). Generic health status scores also improved significantly ( P <0.001 for all). Despite a technically successful procedure in 98% of patients, 21% of patients did not achieve the minimal clinically important improvement of an 8-point change in Peripheral Artery Questionnaire Summary score after PER (35±19 at baseline versus 31±16 at 1 year; P =0.09). Conclusions— For most patients, significant and sustained improvements in symptoms, functioning, and quality of life occur after PER. Identifying and counseling patients less likely to benefit from PER is an important future research direction.

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Section: Editorial P 550 Clinical Perspective P 575mentioning

confidence: 92%

Quantifying Improvement in Symptoms, Functioning, and Quality of Life After Peripheral Endovascular Revascularization

et al. 2007

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“…2 Evidence for treatment efficacy of supervised exercise program (SEP) over PTA is scarce, and it is unclear if combining both treatments gives additional benefit. Two prospective randomized trials comparing PTA with SEP in infrainguinal disease [3][4][5] were limited by small patient numbers. A Cochrane Review on this subject also highlighted difficulties related to lack of blinding and possibility of bias.…”

Section: Introductionmentioning

confidence: 99%

Early Outcomes From a Randomized, Controlled Trial of Supervised Exercise, Angioplasty, and Combined Therapy in Intermittent Claudication

Mazari

Gulati

Rahman

et al. 2010

Annals of Vascular Surgery

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“…20 Whyman et al also examined the outcome of PPI in patients treated with low-dose aspirin, exercise training, and smoking cessation. 21 After 2 years of follow-up, neither walking distance nor ABI were significantly different between patients who had or had not undergone PPI. It must be noted that these studies included patients with suprainguinal as well as infrainguinal lesions, and were not intended to determine the outcome of PPI for SFA lesions.…”

Section: Discussionmentioning

confidence: 89%

Long-Term Outcome After Percutaneous Peripheral Intervention vs Medical Treatment for Patients With Superficial Femoral Artery Occlusive Disease

Kamiya

Sakamoto

Tamori

et al. 2008

Circ J

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Is intermittent claudication improved by percutaneous transluminal angioplasty? A randomized controlled trial

Abstract: Two years after PTA, patients had less extensive disease than medically treated patients, but this did not translate into a significant advantage in terms of improved walking or quality of life. There are important implications for patient management and future clinical research.

Cited by 162 publications

References 14 publications

Quantifying Improvement in Symptoms, Functioning, and Quality of Life After Peripheral Endovascular Revascularization

Quantifying Improvement in Symptoms, Functioning, and Quality of Life After Peripheral Endovascular Revascularization

Early Outcomes From a Randomized, Controlled Trial of Supervised Exercise, Angioplasty, and Combined Therapy in Intermittent Claudication

Long-Term Outcome After Percutaneous Peripheral Intervention vs Medical Treatment for Patients With Superficial Femoral Artery Occlusive Disease

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