Is Inherited Human Herpesvirus 6 the Perpetrator Behind Some Cases of Chronic Fatigue Syndrome?

Lum, Emily; Medveczky, Maria M.; Medveczky, Peter G.

doi:10.2217/fmb.14.11

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…8 In another novel finding, approximately 2% of ME/CFS cases were found to have chromosomally integrated human herpesvirus-6 (HHV-6) as compared to just 0.2%-0.85% of the general population, 9 suggesting a specific etiology for a small proportion of cases. 10 Responses to treatment in randomized, blinded, placebo-controlled trials also point to biological causation, including improvements with valganciclovir in a study of ME/CFS patients with elevated antibody titers to HHV-6 and Epstein-Barr virus 11 , and a preliminary trial (now being repeated in a larger patient group) in which ME/CFS patients responded to rituximab, a monoclonal antibody that targets B cells and is used for the treatment of non-…”

Section: Evidence Of a Real Diseasementioning

confidence: 99%

Chronic Fatigue Syndrome: Where is The Reality?

Mahmoud

2015

Egypt J of Rheumatol & Clinical Immunol

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Section: Evidence Of a Real Diseasementioning

confidence: 99%

Chronic Fatigue Syndrome: Where is The Reality?

Mahmoud

2015

Egypt J of Rheumatol & Clinical Immunol

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“…A group of studies have focused on the role of immune system disorders as a primary cause of the CFS disease. Primary and secondary immunodeficiencies facilitate the emergence of opportunistic infections and result in insufficient control of persistent infections [4], which can trigger certain cases of CFS.…”

Section: Introductionmentioning

confidence: 99%

Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis

et al. 2021

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Introduction: Chronic fatigue syndrome (CFS) is a neurological disease that is accompanied by excessive fatigue or tiredness. There are several reports confirming the association between human herpesvirus 6 (HHV-6) infection and CFS illness. This systematic review and meta-analysis was performed to integrate the information of published studies with regard to this association until May 2021. Methods: The literature search was based on keywords including “chronic fatigue syndrome and HHV 6,” “chronic fatigue syndrome and HHV-6,” “chronic fatigue syndrome and HHV6,” “chronic fatigue syndrome and Herpes virus 6,” and “chronic fatigue syndrome and Herpesvirus6” in MEDLINE (PubMed), Web of Science, and EMBASE. Results: The literature search identified 17 studies to be included in the systematic review and 11 studies in meta-analysis. The symmetry funnel plot and Egger’s test (p value = 0.2) identified no publication bias among studies. Moreover, the low level of I2 revealed homogeneity across studies. Discussion: In conclusion, the association between the HHV-6 infection and CFS incidence was substantiated. However, the results of this study also suggest that further comprehensive studies are needed to solidify the association between HHV-6 and CFS. Future studies should consider additional factors that may have affected the significance of such a correlation.

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Is Inherited Human Herpesvirus 6 the Perpetrator Behind Some Cases of Chronic Fatigue Syndrome?

Cited by 2 publications

References 15 publications

Chronic Fatigue Syndrome: Where is The Reality?

Chronic Fatigue Syndrome: Where is The Reality?

Human Herpesvirus 6 Infection and Risk of Chronic Fatigue Syndrome: A Systematic Review and Meta-Analysis

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