Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies?

Pyatt, David W.; Natelson, Ethan A.; Golden, Richard M.

doi:10.1016/j.yrtph.2008.03.003

Cited by 45 publications

(44 citation statements)

References 101 publications

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“…The importance of this consideration lies in the fact that health effects (cancer) linked to FA exposure are more related with peaks of high concentrations than with long time exposure at low levels [2,23]. The choice of exposure metric should be based on the most biologically relevant exposure measure in order to diminish misclassification of exposure, thus leading to attenuated exposure-response relationships [24].…”

Section: Discussionmentioning

confidence: 99%

“…Considering this, Pyatt et al (2008) pointed out, as a limitation in most epidemiological studies, the lack of data about exposure to peak concentrations. Therefore, in those studies, health effects resulting from occupational exposure to FA are associated to exposure exclusively based on time-weighted average concentrations [23].…”

Section: Discussionmentioning

confidence: 99%

“…For FA occupational exposure, ceiling concentrations might be a better strategy to evaluate exposure and to develop risk assessment once very high exposures over short periods are missed by TWA 8 h method and, in fact, they are important to know the real risk for health [23,31]. Therefore, as in other investigations [33,34], it is possible to conclude that when measuring only TWA 8 h poor information is obtained, and the method is of less utility to identify processes that should be targeted for controls.…”

Section: Discussionmentioning

confidence: 99%

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Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

Viegas¹,

Ladeira²,

Nunes³

et al. 2010

Toxicology Letters

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Background: According to the Report on Carcinogens, formaldehyde ranks 25 th in the overall U.S. chemical production, with more than 5 million tons produced each year. Given its economic importance and widespread use, many people are exposed to formaldehyde environmentally and/or occupationally. Presently, the International Agency for Research on Cancer classifies formaldehyde as carcinogenic to humans (Group 1), based on sufficient evidence in humans and in experimental animals. Manyfold in vitro studies clearly indicated that formaldehyde can induce genotoxic effects in proliferating cultured mammalian cells. Furthermore, some in vivo studies have found changes in epithelial cells and in peripheral blood lymphocytes related to formaldehyde exposure.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

Viegas¹,

Ladeira²,

Nunes³

et al. 2010

Toxicology Letters

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“…The metabolic pathway to formate production is catalyzed by cytosolic glutathione (GSH)-dependent formaldehyde dehydrogenase (FDH). The reaction of formaldehyde with GSH yields (S)-hydroxymethylglutathione which, in the presence of NAD+ and FDH, forms the thiol ester of formic acid via the action of (S)-formyl glutathione hydrolase (SFGH) (Pyatt et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Effects of Exposure to Formaldehyde in Two Different Occupational Settings

Viegas¹,

Ladeira²,

Gomes³

et al. 2012

Carcinogen

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“…Established chemical leukemogens are genotoxic and are capable of inducing toxicity to the blood forming system. FA is A c c e p t e d m a n u s c r i p t 4 genotoxic but data on FA hematotoxicity are limited and inconsistent (reviewed by Zhang et al 2009;Pyatt et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15ppm formaldehyde vapor

Kuper

Oostrum

Ma‐Hock

et al. 2011

Experimental and Toxicologic Pathology

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perplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15 ppm formaldehyde vapor. Experimental and Toxicologic Pathology, Elsevier, 2010, 63 (1-2) This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting galley proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractTo investigate if local lymphoid tissues are a target of FA, nasopharynx-associated lymphoid tissues (NALT) and upper-respiratory tract-draining lymph nodes were examined in a 28-day inhalation study with FA vapor in Fischer-344 rats and B6C3F1 mice.Paraffin-embedded tissues were sectioned and stained with H&E or stained immunohistochemically for cell proliferation (BrdU incorporation).Light microscopy revealed simple hyperplasia of NALT lymphoepithelium of rats exposed to 15 ppm and an increased proliferation rate of the epithelial cells. Principal component (discriminant) analysis of rat NALT and lymph nodes data did not reveal other effects or effects at lower exposure levels. Mice tissues were not affected.It was concluded that hyperplasia of the lymphoepithelium of NALT of rats exposed to 15 ppm was the only distinct effect of FA vapor on local lymphoid tissues (NALT and lymph nodes) of Fischer-344 rats and B3C3F1 mice.

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Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies?

Cited by 45 publications

References 101 publications

Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

Genotoxic Effects of Exposure to Formaldehyde in Two Different Occupational Settings

Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15ppm formaldehyde vapor

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