Is impaired kidney function an independent predictor of the risk of myocardial infarction in HIV-infected individuals?

Abstract

We examined whether impaired kidney function is an independent risk factor for myocardial infarction in HIV-infected individuals without pre-existing coronary artery disease. The odds ratio for impaired kidney function fell from 1.22 (95% confidence interval 0.90-1.66) to 0.99 (95% confidence interval 0.69-1.41) after adjustment for cardiovascular risk factors and HIV-related parameters, with hypertension, high-density lipoprotein cholesterol, smoking and the CD4 T-cell nadir as most influential confounders. In this setting, no association was found between impaired kidney function and the risk of myocardial infarction.

Increased Risk of Radiographic Emphysema in HIV Is Associated With Elevated Soluble CD14 and Nadir CD4

“…Nadir CD4 cell count refl ects past HIV-related immunosuppression and predicts immune recovery. 36 Low nadir CD4 counts may induce incompletely reversible defects in immune function 37 and correlates with cardiovascular 38 and chronic kidney 39 diseases. Low nadir CD4 is also a marker for increased likelihood of prior opportunistic infections.…”