Is IgG anti-GT1a antibody associated with pharyngeal–cervical–brachial weakness or oropharyngeal palsy in Guillain–Barré syndrome?

Anti-GT1a IgG in Guillain-Barre syndrome

“…None of them had been included in our previous studies. 15 21 The diagnosis of GBS was based on established clinical criteria. 22 Patients who initially presented with ophthalmoplegia, ataxia, and areflexia and later developed generalised muscle weakness were also included with the GBS population.…”

“…By this criterion, anti-GT1a IgG was positive in 11 (73%) of 15 patients with MFS, one (2%) of 50 patients with amyotrophic lateral sclerosis, and one (2%) of 50 healthy subjects. 21 An absorption study, performed as described elsewhere, 21 used microtitre plates coated with 10 pmol portions of ganglioside. Serum samples were added to the wells at a dilution that gave an absorbance of 1.0-2.0.…”

Guillain-Barré Syndrome Presenting Pharyngeal-Cervical-Brachial Weakness in the Recovery Phase

“…Mizoguchi et al [2] reported a patient with PCB-like symptoms who had anti-GT1a and anti-GD1a IgG antibodies. Kashihara et al [3] and Koga et al [4] reported typical PCB patients who had anti-GT1a IgG antibodies which do not cross-react with GQ1b. They speculated that these antibodies can serve as serological markers for PCB [4].…”

“…Kashihara et al [3] and Koga et al [4] reported typical PCB patients who had anti-GT1a IgG antibodies which do not cross-react with GQ1b. They speculated that these antibodies can serve as serological markers for PCB [4]. In our patient's case, several antiganglioside antibodies were detected in the acute phase, but only the anti-GT1a IgG antibody titer remained high in the recovery phase.…”

Fulminant Guillain-Barrè Syndrome after Campylobacter Jejuni Enteritis and Anti-Ganglioside Antibody

“…It has been postulated that anti-GTla reactivity is more closely associated with oropharyngeal palsy, but without ophthalmoplegia, has been reported (20). Recently, it was concluded by Koga et al that oropharyngeal palsy is associated with anti-GTla, which did not cros-sreact with antiGQlb (21). The fine specificity of the anti-ganglioside antibodies, as assessed by relative titres to GQlband GTla and reactivity with other structurally similar disialosyl containing gangliosides such as GDld, GD3and GTlb, is compatible with many previous studies (22,23).…”