Is<i> Helicobacter pylori </i>related to endothelial dysfunction during childhood?

Coşkun, Şenol; Kasırga, Erhun; Yılmaz, Özge; Bayındır, Petek; Akil, İpek; Yüksel, Hasan; Polat, Muzaffer; Şanlıdağ, Tamer

doi:10.1111/j.1442-200x.2008.02542.x

Cited by 21 publications

(22 citation statements)

References 15 publications

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“…Therefore, in accordance with the current results, the effect helicobacter may be independent of producing inflammatory cytokines, such as IL-12. C-reactive level in the current study patients was not significantly higher in children with H. pylori infection; this result is in line with Coskun et al's study (20), and it may be due to the method for CRP check. The current researchers did not use hsCRP level check, which is more sensitive.…”

Section: Discussionsupporting

confidence: 91%

The Association of Helicobacter pylori Infection with Endothelial Dysfunction in Pediatric Patients

Pourmoghaddas

Ansari

Dehghan

et al. 2018

Arch Pediatr Infect Dis

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Objectives: The aim of this study was to evaluate endothelial dysfunction in pediatric patients with Helicobacter pylori infection. Methods: In a cross sectional study, 50 children between six and twelve years old were evaluated for Helicobacter pylori infection by a histopathologic specimen. C-reactive protein (CRP) and Interleukin-12 of all subjects was checked. Endothelial dysfunction was evaluated by echocardiography of brachial artery and through measuring flow mediated dilatation (FMD). Results: Mean of FMD level was significantly higher in children with H. pylori infection (P value: 0.04). Interlukin-12 (IL-12) was higher in children with H. pylori infection (P value: 0.04). Linear regression showed a positive association of Helicobacter pylori infection and endothelial dysfunction (beta = 0.3, P value = 0.08). Conclusions: Children with Helicobacter pylori infection have more endothelial dysfunction independent of IL-12.

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Section: Discussionsupporting

confidence: 91%

The Association of Helicobacter pylori Infection with Endothelial Dysfunction in Pediatric Patients

Pourmoghaddas

Ansari

Dehghan

et al. 2018

Arch Pediatr Infect Dis

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“…Heat shock proteins (HSPs), highly conserved decreases the risk of cardiovascular disease by decreasing the serum ADMA level 67,68) . In addition to evidence suggesting a link between H. pylori infection and endothelial dysfunction, there are contradictory data showing no association between H. pylori infection and the endothelial function 69,70) . Consequently, further investigation to determine whether H. pylori infection contributes to the development of endothelial dysfunction, ultimately resulting in atherosclerosis, is warranted.…”

Section: H Pylori Molecular Mimicry and Atherosclerosismentioning

confidence: 99%

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

Yang

Lü

2014

JAT

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Accumulating evidence implicates Helicobacter pylori (H. pylori) infection in the pathogenesis of certain diseases localized outside the stomach, particularly those characterized by persistent and lowgrade systematic inflammation. Recently, the role of H. pylori infection in the development of atherosclerosis and its clinical complications has received attention. Atherosclerosis is a high-cost disease, and acute events resulting from this condition rank first among morbidity and mortality statistics in most industrialized countries. Atherosclerosis is a multifactorial disorder, and traditional risk factors explain only 50% of its etiology. Therefore, identifying new risk factors for atherosclerosis is necessary. Serological studies indicate that chronic H. pylori infection, especially that with more virulent strains, may predispose patients to the onset of atherosclerosis and related adverse clinical events, and PCR studies have detected H. pylori DNA in atherosclerotic plaques, although this finding remains controversial. If this association were to be confirmed, its importance to public health would be substantial, as the eradication of H. pylori is more straightforward and less costly than the longterm treatment of other risk factors. This review investigates the potential relationship between H. pylori infection and atherosclerosis from both epidemiological and pathogenic perspectives and characterizes the potential mechanisms underlying this correlation.

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“…Additionally, it has been shown that endothelial dysfunction improves after the eradication of H. pylori infection (3). It should be noted that some evidence does not support the linkage between H. pylori infection and endothelial dysfunction (44,45). H. pylori as an infection can lead to at least a low grade persistent systemic inflammation and stimulates the production of some inflammatory cytokines, such as Il-6, CRP, and Il-18.…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Helicobacter pylori Infection and Atherosclerosis: A Meta-analysis

Ramezani-Binabaj¹,

Jannat²,

Safiabadi³

et al. 2016

Erciyes Med J

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Materials and Methods: The current review was conducted on studies published from January 1, 2000 to November 15, 2014 through Scopus, Web of sciences, Google scholar, Embase, and two MEDLINE database engines: PubMed and Ovid. Different combinations of the following keywords "Helicobacter pylori, H. pylori, atherosclerotic plaques, atherosclerotic lesion, and atherosclerotic vascular disease" were used. Results: Four good-quality investigations met our inclusion criteria. The pooled odd ratio (OR) for the presence of H. pylori in the atherosclerotic plaques of patients with atherosclerotic vascular disease in a fixed model was 4.65 (95% CI=1.99-10.85, p=0.001). According to the chi-square test, there was a significant heterogeneity (67.6%) among studies (p=0.026). In a random effects method, the pooled OR was 5.98 (95% CI=0.69-51.99, p=0.10). Conclusion: According to the results of this meta-analysis, H. pylori is not a significant risk factor for atherosclerotic vascular disease. However, evidence on this effect is inadequate. Hence, more original studies are still needed.

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Is Helicobacter pylori related to endothelial dysfunction during childhood?

Cited by 21 publications

References 15 publications

The Association of Helicobacter pylori Infection with Endothelial Dysfunction in Pediatric Patients

The Association of Helicobacter pylori Infection with Endothelial Dysfunction in Pediatric Patients

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

The Relationship between Helicobacter pylori Infection and Atherosclerosis: A Meta-analysis

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