Is<i>Helicobacter pylori</i>infection associated with glycemic control in diabetics?

Dai, Yihu; Yu, Wei-Lai; Zhu, Hongyan; Ding, Jinwang; Yu, Chaohui; Li, Youming

doi:10.3748/wjg.v21.i17.5407

Cited by 45 publications

(54 citation statements)

References 41 publications

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“…However, a recent meta‐analysis reported that no solid evidence is available for the worsening of T2DM control by H. pylori infection, and no consensus has been reached. With regard to H. pylori eradication, it has been reported that eradication does not improve the T2DM control status, and H. pylori eradication is more likely to fail in DM (including type 1 DM) patients than in non‐DM patients . Moreover, eradication has been reported to improve insulin resistance in patients with a type B insulin receptor abnormality, a subtype of DM .…”

Section: Indicationsmentioning

confidence: 99%

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

et al. 2019

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Background Since “Helicobacter pylori (H. pylori) infection” was set as the indication in the Japanese Society for Helicobacter Research (JSHR) Guidelines 2009, eradication treatment for H. pylori gastritis is covered under insurance since 2013 in Japan, and the number of H. pylori eradication has rapidly increased. Under such circumstances, JSHR has made the third revision to the “Guidelines for diagnosis and treatment of H. pylori infection” for the first time in 7 years. Methods The Guideline Committee held 10 meetings. Articles published between the establishment of the 2009 Guidelines and March 2016 were reviewed and classified according to the evidence level; the statements were revised on the basis of this review. After inviting public comments, the revised statements were finalized using the Delphi method. Results There was no change in the basic policy that H. pylori infectious disease is an indication for eradication. Other diseases presumed to be associated with H. pylori infection were added as indications. Serum pepsinogen level, endoscopic examination, and X‐ray examination were added to the diagnostic methods. The effects of 1‐week triple therapy consisting of potassium‐competitive acid blocker (P‐CAB), amoxicillin, and clarithromycin have improved, and high eradication rates can also be expected with proton pump inhibitors (PPI) or P‐CAB combined with amoxicillin and metronidazole. If the susceptibility test is not performed, the triple PPI or P‐CAB/amoxicillin/metronidazole therapy should be chosen, because the PPI/amoxicillin/metronidazole combination demonstrated a significantly higher eradication rate than PPI/amoxicillin/clarithromycin. In the proposal for gastric cancer prevention, we divided gastric cancer prevention measures by age from adolescent to elderly, who are at an increased gastric cancer risk, and presented measures for gastric cancer prevention primarily based on H. pylori eradication. Conclusion We expect the revised guidelines to facilitate appropriate interventions for patients with H. pylori infection and accomplish its eradication and prevention of gastric cancer.

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Section: Indicationsmentioning

confidence: 99%

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

et al. 2019

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“…The incidence of positivity increased with age. The number of positive cases were more in males (n-18, 36.7%) then females (7,22.6%) p-0.18 (Table 1). When compared with HbA1C levels mean HbA1C was higher in the H. Pylori positive group 7.92±2.1 vs. 7.51±1.5, p=0.34 (Table 4).…”

Section: Resultsmentioning

confidence: 87%

“…Similar association has been found in many previous studies. 6,7 Long duration of disease, poor hygiene and poor glycaemic control has been associated with diabetes in positive cases. 8,9 There has been association of awareness of disease and the association of H. Pylori positivity in cases of diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…6 In the last 2 -3 years there are a lot of research publications showing association and non-association of H Pylori infection and diabetes. 7,8,9 Issues of poor socioeconomic status ,poor hygiene and lowering of immunity amongst diabetic patients has been an explanation for the association. 10 There are reports igniting newer point of views i.e.…”

Section: Introductionmentioning

confidence: 99%

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A Questionnaire Based Survey on Awareness and Study of Helicobacter Pylori Infection and Ty Pe 2 Diabetes in Central India

Chittawar¹,

Jagat²,

Sharma³

et al. 2015

jemds

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Awareness of Diabetes in India is the need of hour. Questionnaire based survey to assess the awareness was done. Helicobacter Pylori infection is one of the forerunners in the number of people infected and gastrointestinal disorders .Single point cross-sectional observational study was done to evaluate the association of Helicobacter Pylori infection and diabetes. Eighty diabetic patients (49 males, 31 females 55.3±12 years) were enrolled in the study. 25(31%) patients were positive for H pylori and rest 55(69%) patients were negative for the test. There was no gender difference and the awareness of diabetes and its treatment was same in both the groups. Duration of diabetes, glycaemic control and awareness of disease and treatment has got an association of H Pylori infection and type 2 diabetes. Better designed large studies are required to establish the cause and association.

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“…Camel milk is also rich in amino acids including valine, methionine, lysine, arginine and phenylalanine. It also contains high amounts of albumin and globulin (3). The aim of this study is to investigate the in vitro antagonistic effects of probiotics isolated from camel milk on the growth of clinical strains of H. pylori resistant to selective agents.…”

mentioning

confidence: 99%

Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori

Sikarchi

Fozouni

2018

mljgoums

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Background and Objectives: Helicobacter pylori is the most common cause of gastritis and ulcer worldwide. Treatment of such infections may lead to failure due to drug resistance. This study aimed to investigate the antimicrobial effects of bacteria present in camel milk on the growth of drug-resistant clinical isolates of H. pylori.Methods: In this cross-sectional study, biopsy samples from 75 patients with digestive symptoms were transferred to laboratory in transport medium containing homogeneous compounds. In order to isolate H. pylori, urease-positive biopsies were promptly cultured in brucella agar enriched with defibrinated sheep blood and fetal calf serum. Disk diffusion agar test was used to evaluate antibiotic susceptibility and agar well diffusion method was applied to study the antagonistic effect of probiotics isolated from camel milk on the H. pylori isolates.Results: The frequency of H. pylori isolates was 42.7%. The highest rate of resistance was observed against metronidazole (56.3%). In addition, the rate of resistant to amoxicillin, ciprofloxacin, and clarithromycin and tetracycline was 31.3%, 18.8%, 15.6%, respectively. Lactobacillus plantarum (59.3%) was more frequent than other Lactobacillus species. L. plantarum, Lactobacillus fermentum and Lactobacillus casei showed favorable inhibitory effects against the H. pylori isolates, but L. plantarum (with inhibition zone diameter of 20.3 mm) showed the highest inhibitory effect.Conclusion: Considering the increasing rate of drug resistance and the inhibitory effect of probiotics isolated from milk, health providers recommend that promoting consumption of probiotic food seems beneficial for the general population and those suffering from gastrointestinal disorders.

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IsHelicobacter pyloriinfection associated with glycemic control in diabetics?

Abstract: H. pylori infection is associated with poorer glycemic control in T1DM patients, but eradication may not improve glycemic control in DM in a short-term follow-up period.

Cited by 45 publications

References 41 publications

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

Guidelines for the management of Helicobacter pylori infection in Japan: 2016 Revised Edition

A Questionnaire Based Survey on Awareness and Study of Helicobacter Pylori Infection and Ty Pe 2 Diabetes in Central India

Inhibitory Effect of Probiotic Bacteria Isolated from Camel Milk on Clinical Strains of Drug-Resistant Helicobacter pylori

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