Is hydroxychloroquine beneficial for COVID-19 patients?

Li, Xing; Wang, Ying; Agostinis, Patrizia; Rabson, Arnold B.; Melino, Gerry; Carafoli, Ernesto; Shi, Yufang; Sun, Erwei

doi:10.1038/s41419-020-2721-8

Cited by 103 publications

(101 citation statements)

References 63 publications

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“…In Table 3 the summary statistics is presented. As it can been seen, the speci city of both COVID- 19…”

Section: Introductionmentioning

confidence: 82%

“…The S2 segment anchors the S protein to the viral membrane, contains the fusion peptide which mediates the fusion of the viral membrane with the plasma membrane of the target cell. The proteases responsible for the S protein activation represents promising drug targets for the treatment of the disease, following failure of rst attempts, such as hydroxychloroquine 19 .…”

Section: Introductionmentioning

confidence: 99%

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Serological Determinants of COVID-19

Noce

Santoro

Marrone

et al. 2020

Preprint

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Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spreaded rapidly worldwide, as far as it has become a global pandemic. Therefore, the introduction of serological tests useful for the determination of IgM and IgG antibodies, it has become the main diagnostic tool, useful for tracking the spread of the virus and consequently its containment. In our study we compared point of care test (POCT) lateral flow immunoassay (FIA) vs automated chemiluminescent immunoassay (CLIA), in order to assess their specificity and sensibility against COVID-19 antibodies detection. Results: We find that different specificities and sensitivities for IgG and IgM tests. Notably IgM POCT FIA method vs CLIA method (gold standard) has a low sensitivity (0.526), while POCT FIA method vs CLIA method (gold standard) test has a much higher sensitivity (0.937); further, with respect of IgG, FIA and CLIA could arguably provide the same information. Conclusions: FIA method could be helpful in assessing in short time, the possible contagiousness of subjects that for work reasons cannot guarantee “social distancing”.

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“…In Table 3 the summary statistics is presented. As it can been seen, the speci city of both COVID- 19…”

Section: Introductionmentioning

confidence: 82%

Section: Introductionmentioning

confidence: 99%

Serological Determinants of COVID-19

Noce

Santoro

Marrone

et al. 2020

Preprint

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“…Given this report, on 30 March 2020, the US FDA gave Emergency Use Authorization (EUA) to HCQ/CQ for treatment of COVID-19, in the absence of any other approved therapy. 4 In a retrospective multicenter cohort study in 25 different hospitals on 1438 patients with distinct medications and pre-existing conditions, there were no significant differences in mortality for patients receiving HCQ + azithromycin, HCQ alone, or azithromycin alone. On 24 April 2020, FDA cautioned against the use of CQ/HCQ outside the hospital settings or a clinical trial.…”

Section: Hydroxychloroquine and Chloro-quine (Hcq/cq)mentioning

confidence: 95%

Medical management of COVID-19: treatment options under consideration

Kabi

Mohanty

Mohanty³

et al. 2020

Int J Adv Med

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An outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China in December 2019. Despite the worsening trends of COVID-19, currently, no drugs are validated to have significant efficacy in the clinical treatment of COVID-19. The drugs currently being explored are hydroxychloroquine, antivirals like remdesivir, favipiravir alone or in combination, antibiotics like azithromycin and doxycycline. Low dose corticosteroids, either oral or intravenous, have also shown promising results in reducing mortality. On the other hand, Immunomodulators and biologics are found to be very effective in some cases. Autopsy finding of patients with COVID-19 shows the evidence of endothelial damage and formation of microthrombi with multiorgan involvement and, ultimately, multiorgan failure; hence anticoagulants also seem to have a definite role in preventing microvasculature clogging and multiorgan dysfunction. Pulmonary vasodilators acting via the cGMP/cAMP pathway may also prove to be beneficial in reducing airway hyper inflammation. In this review, authors have attempted to summate the potential drugs therapies with emphasis on convalescent plasma, and at last, the most awaited thing of this pandemic, COVID-19 vaccine.

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“…No need to discontinue this drug during pregnancy. 51 If Systemic lupus erythematosus (SLE) women on this drug become pregnant; it has not shown any adverse effects on the fetus even though the cord blood sample has the same concentration of the drug of the mother serum concentration.…”

Section: Drug-drug and Drug-disease Interactions In Females With Covimentioning

confidence: 99%