Is human <scp>T</scp>‐lymphotropic virus type 1 infection associated with hearing loss?

Bakhshaee, Mehdi; Sorouri, Amirhossein; Shoeibi, Ali; Boustani, Reza; Golhasani-Keshtan, Farideh; Amali, Amin; Rajati, Mohsen

doi:10.1002/lary.24982

Cited by 3 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This pathway decreases to fifth rank in the treated SSNHL sub‐group. The classic neurological presentation of HTLV‐1 infection is a myelopathy called HTLV‐1 associated myelopathy/tropical spastic paraparesis and individuals infected with this virus have been reported to present with hearing loss . Furthermore, miR‐590‐5p was significantly upregulated in SSNHL patients ( P = .009).…”

Section: Discussionmentioning

confidence: 99%

microRNAs in sudden hearing loss

et al. 2019

View full text Add to dashboard Cite

Objectives: To compare the circulating microRNA (miRNA) expression profiles between sudden sensory neural hearing loss (SSNHL) patients and age-matched normal hearing controls.Study Design: Prospective cohort multi-center study. Methods: Patients presenting within 28 days of onset of SSNHL were prospectively recruited along with contemporaneous age-matched controls. Pooled sera of four patient (n = 09, mean age = 53.0 years; 07, 55.0; 10, 52.9; 10, 51.6) and two control (09, 51.2 and 03, 50.0) groups were assessed using a TaqMan Low Density Array. The patients' sera were also divided into two pools, untreated (04, 57.7) and treated (32, 52.6) for additional analysis. miRNA expression level was derived from cycle threshold (Ct) values normalized to a global mean. Inter-group mean Ct differences with fold changes ≥2.0 and ≤0.5 at P < .05 were considered significant. Bioinformatic databases were used to identify putative target mRNAs or validated genes and their functional annotations.Results: Thirty-six SSNHL patients (mean age 53.0 AE standard deviation (SD) 15.2 years) and 12 controls (50.9 AE 11.9) were studied. Eight miRNAs hsa-miR-590-5p/ -186-5p/ -195-5p/ -140-3p/ -128-3p/ -132-3p/ -375-3p, and -30a-3p were identified as significantly differentially expressed in SSNHL patients. Most of these miRNAs were abundantly identified in the nervous system and the putative target messenger RNAs (mRNAs) were enriched in signaling pathways such as phosphatidyl inositol 3 kinase/protein Kinase B (PI3K/Akt), Ras and mitogen-activated protein kinase (MAPK).Conclusion: These findings suggest the possible cellular signaling pathways that underlie the disruption of auditory signal transmission in SSNHL.

show abstract

Section: Discussionmentioning

confidence: 99%

microRNAs in sudden hearing loss

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The combined plantar pressure and stabilometric results indicate that HAM/TSP patients had a significant postural control deficit, which can lead to an increase in risk of falls; that asymptomatic HTLV-1 infected patients are sub-clinically susceptible to these balance impairments; and that they need continuous evaluations of their postural control. Other studies have found functional loss in HTLV-1 patients compared to the control group, such as altered plantar foot pressure 18 , hearing loss 27 , and impaired vestibular evoked myogenic potentials 28 . Nagai et al .…”

Section: Discussionmentioning

confidence: 89%

Balance Impairments in Patients with Human T-Cell Lymphotropic Virus Type 1 Infection

Vasconcelos

Callegari

Costa

et al. 2019

Sci Rep

View full text Add to dashboard Cite

The human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus from the Retroviridae family that infects cluster of differentiation 4 (CD4) T-lymphocytes and stimulates their proliferation. A severe consequence of this infection can be the HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP), which is associated with a progressive demyelinating disease of the upper motor neurons. The HAM/TSP conditions frequently present with neurological complaints such as gait impairment, sphincter disturbances, and several sensory losses. We compared findings from the posturographic evaluation from the asymptomatic HTLV-1 infected subjects, HTLV-1 infected subjects having HAM/TSP, and control group database. A force plate was used to record the postural oscillations. Analysis of variance and multivariate linear discriminant analysis were used to compare the data obtained from the three groups of participants. In general, HAM/TSP patients had worse postural balance control than did the HTLV-1 patients and the controls (p < 0.05). We found that in six out of ten parameters of the postural balance control, there was a gradual increase in impairment from control to HTLV-1 to HAM/TSP groups. All parameters had higher values with the subject’s eyes closed. The multivariate linear discriminant analysis showed there was a reasonable difference in results between the control and HAM/TSP groups, and the HTLV-1 group was at the intersecting area between them. We found that HAM/TSP patients had worse balance control than did HTLV-1 infected patients and the control group, but asymptomatic HTLV-1 infected patients represent an intermediate balance control status between controls and HAM/TSP patients. Posturographic parameters can be relied on to identify subtle changes in the balance of HTLV-1 patients and to monitor their functional loss. HTLV-1 is a tropical disease that can be transmitted by sexual intercourse, blood transfusion, and breast-feeding. Some infected subjects develop an HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a condition characterized by spasticity, weakness in lower limbs, and difficulty in walking long distances and going up and down the stairs, besides the history of falls. We compared the body oscillations using a force plate to investigate the postural balance control. HTLV-1 infected patients had imbalance that could be identified by posturographic parameters. Patients with HAM/TSP clearly had balance impairments, while HTLV-1 without HAM/TSP had a subtle impairment that was not seen on clinical scales, suggesting that these patients were in the middle between healthy and HAM/TSP patients, and carried a risk of developing severe imbalance postural control. We suggest that more research should be done with the aim to identify the subtle signs in asymptomatic HTLV-1 patients to investigate if this group of patients need attention similar to the HAM/TSP patients.

show abstract