Is Hormonal Therapy Associated with Better Quality of Life in Transsexuals? A Cross‐Sectional Study

Gorin-Lazard, Audrey; Baumstarck, Karine; Boyer, Laurent; Maquigneau, A.; Gebleux, Stéphanie; Penochet, Jean-Claude; Pringuey, D.; Albarel, F.; Morange, Isabelle; Loundou, Anderson; Berbis, Julie; Auquier, Pascal; Lançon, Christophe; Bonierbale, M.

doi:10.1111/j.1743-6109.2011.02564.x

Cited by 152 publications

(142 citation statements)

References 38 publications

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“…9 In a study comparing quality of life between transwomen on and off hormones, hormonal therapy was associated with higher scores in general and mental health. 10 A study by Rotundi found that transgender people ready but not able to medically transition are more likely to have depressive symptoms than peers who have begun the process. 11 The ensuing combination of hopelessness and depression results in participation in high-risk sexual behaviors.…”

Section: Introductionmentioning

confidence: 99%

Connecting the Dots: Examining Transgender Women’s Utilization of Transition-Related Medical Care and Associations with Mental Health, Substance Use, and HIV

et al. 2014

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Findings on access to general healthcare for transgender people have emerged, but little is known about access to transition-related medical care for transwomen (i.e., hormones, breast augmentation, and genital surgery). Transgender women have low access to general medical care and are disproportionately at risk for substance use, mental illness, and HIV. We conducted an analysis to determine if utilization of transition-related medical care is a protective factor for health risks to transgender women and to investigate if care differs by important demographic factors and HIV status. A secondary analysis was conducted using data from a 2010 HIV surveillance study using respondent-driven sampling to recruit 314 transwomen in San Francisco. Survey-corrected logistic regression models were used to estimate odds ratios for six psychosocial health problems-binge drinking, injection drug use, anxiety, depression, suicidal ideation, and high-risk intercourse-comparing various levels of utilization of transition-related medical care. Odds ratios were also calculated to determine if utilization of transition-related medical care was related to less overlap of risk domains. We found that Latina and African American transwomen had significantly lower estimated utilization of breast augmentation and genital surgery, as did transwomen who identified as transgender rather than female. Overall, utilization of transition-related medical care was associated with significantly lower estimated odds of suicidal ideation, binge drinking, and non-injection drug use. Findings suggest that utilization of transition-related medical care may reduce risk for mental health problems, especially suicidal ideation, and substance use among transwomen. Yet, important racial/ethnic and gender identity disparities in utilization of transition-related medical care need to be addressed.

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Section: Introductionmentioning

confidence: 99%

Connecting the Dots: Examining Transgender Women’s Utilization of Transition-Related Medical Care and Associations with Mental Health, Substance Use, and HIV

et al. 2014

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“…Changes to the effectiveness, safety and availability of interventions for gender dysphoria, 4,13,16,35 combined with an evolution of social attitudes, are possible reasons for the observed increase in presentations to gender services for transition. 9,64 The burden of disease attributable to gender dysphoria is difficult to establish, but is likely to be significant.…”

Section: Discussionmentioning

confidence: 99%

“…11 Although treatment of gender dysphoria is associated with improvements, 4,16 substantial mental ill-health persists after transition. 14 In one large cohort, those who had undergone sex reassignment surgery (SRS) remained 4.9-fold more likely than controls to have attempted suicide, and 19.1-fold more likely to have died from suicide.…”

Section: Mental Healthmentioning

confidence: 99%

“…19 Testosterone use in transgender men is accompanied by improvements in mood and libido. 4,20 Gender dysphoria occurs with higher frequency among those with autism spectrum disorders (ASD). 21,22 Establishing the diagnosis of gender dysphoria in the presence of ASD requires involvement of mental health professionals with experience of both conditions.…”

Section: Mental Healthmentioning

confidence: 99%

“…Overall, transition improves the symptoms of dysphoria and quality of life in~80% of transwomen and transmen. 2 Endocrine therapy is associated with a significantly better quality of life, greater self-esteem, better mood, 4 and reductions in psychological distress. 5 Regret about gender transition is uncommon, [6][7][8] experienced by 2.2% of those in a large Swedish cohort study, 8 and the proportion of those who experienced regret was lowest among those who commenced transition in the current era.…”

Section: Introductionmentioning

confidence: 99%

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The primary health care of transgender adults

Aitken¹

2017

Sex. Health

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Abstract. Gender dysphoria is associated with significant health disparity. Gender services perform specialised activities such as diagnosis, endocrine management and liaison with surgical services. Although providing these specialised transition services appears to be safe and improves well-being, significant health disparity remains. Engaging primary care providers is an important part of any strategy to improve the health care of transgender people. The relationships between gender dysphoria and a range of primary care issues such as mental health, cardiovascular disease and cancer are explored.

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Implementation of Patient-Reported Outcome Measures for Gender-Affirming Care Worldwide

et al. 2023

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ImportanceGender-affirming care is a key clinical area that can benefit from implementation of patient-reported outcome measures (PROMs). Identifying barriers to and enablers of PROM implementation is needed to develop an evidence-based implementation strategy.ObjectiveTo identify (1) PROMs previously implemented for gender-affirming care and constructs measured, (2) how patients completed PROMs and how results were reported and used, and (3) barriers to and enablers of PROM implementation.Evidence ReviewIn this systematic review, PubMed, Embase, MEDLINE, PsycINFO, CINAHL, and Web of Science were searched from inception to October 25, 2021, and updated on December 16, 2022. Gray literature was searched through gray literature database, online search engine, and targeted website searching. Inclusion criteria were (1) original articles of (2) a formally developed PROM or ad hoc instrument administered for gender-affirming care to (3) patients accessing gender-affirming care. The Critical Appraisal Skills Programme tool was used to evaluate quality of included studies. This review was registered on PROSPERO (CRD42021233080).FindingsIn total, 286 studies were included, representing 85 395 transgender and nonbinary patients from more than 30 countries. A total of 205 different PROMs were used in gender-affirming care. No studies described using an implementation science theory, model, or framework to support PROM deployment. Key barriers to PROM implementation included issues with evidence strength and quality of the PROM, engaging participants, and PROM complexity. Key enablers of PROM implementation included using PROMs validated for gender-affirming care, implementing PROMs able to be deployed online or in person, implementing PROMs that are shorter and reduce patient burden, engaging key stakeholders and participants as part of developing an implementation plan, and organizational climate.Conclusions and RelevanceIn this systematic review of barriers to and enablers of PROM implementation in gender-affirming care, PROM implementation was inconsistent and did not follow evidence-based approaches in implementation science. There was also a lack of patient input in creating implementation strategies, suggesting a need for patient-centered approaches to PROM implementation. Frameworks created from these results can be used to develop evidence-based PROM implementation initiatives for gender-affirming care and have potential generalizability for other clinical areas interested in implementing PROMs.

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Is Hormonal Therapy Associated with Better Quality of Life in Transsexuals? A Cross‐Sectional Study

Cited by 152 publications

References 38 publications

Connecting the Dots: Examining Transgender Women’s Utilization of Transition-Related Medical Care and Associations with Mental Health, Substance Use, and HIV

Connecting the Dots: Examining Transgender Women’s Utilization of Transition-Related Medical Care and Associations with Mental Health, Substance Use, and HIV

The primary health care of transgender adults

Implementation of Patient-Reported Outcome Measures for Gender-Affirming Care Worldwide

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