Is histological prostate inflammation in an initial prostate biopsy a predictor of prostate cancer on repeat biopsy?

Yun, Bu Hyeon; Hwang, Eu Chang; Yu, Ho Song; Chung, Ho Seok; Kim, Sun-Ouck; Jung, Seung Il; Kang, Taek Won; Kwon, Dong Deuk; Park, Kwangsung; Choi, Chan

doi:10.1007/s11255-015-1029-6

Cited by 11 publications

(5 citation statements)

References 33 publications

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“…Studies have shown that the presence of infiltrating immune cells in prostatic tissues is inversely correlated to PCa progression [203,204]. Prostatic inflammation, experimentally induced by intra-prostatic injection of formalin, leads to increased NRLP1 expression and consequent increase in IL-1β, IL-18 and caspase-1 levels [205].…”

Section: Impact Of Nlrs On Cancermentioning

confidence: 99%

NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer

et al. 2019

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Innate immunity comprises several inflammation-related modulatory pathways which receive signals from an array of membrane-bound and cytoplasmic pattern recognition receptors (PRRs). The NLRs (NACHT (NAIP (neuronal apoptosis inhibitor protein), C2TA (MHC class 2 transcription activator), HET-E (incompatibility locus protein from Podospora anserina) and TP1 (telomerase-associated protein) and Leucine-Rich Repeat (LRR) domain containing proteins) relate to a large family of cytosolic innate receptors, involved in detection of intracellular pathogens and endogenous byproducts of tissue injury. These receptors may recognize pathogen-associated molecular patterns (PAMPs) and/or danger-associated molecular patterns (DAMPs), activating host responses against pathogen infection and cellular stress. NLR-driven downstream signals trigger a number of signaling circuitries, which may either initiate the formation of inflammasomes and/or activate nuclear factor κB (NF-κB), stress kinases, interferon response factors (IRFs), inflammatory caspases and autophagy. Disruption of those signals may lead to a number of pro-inflammatory conditions, eventually promoting the onset of human malignancies. In this review, we describe the structures and functions of the most well-defined NLR proteins and highlight their association and biological impact on a diverse number of cancers.

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Section: Impact Of Nlrs On Cancermentioning

confidence: 99%

NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer

et al. 2019

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“…1,2 Moreover, several studies found no association between inflammation and PCa. [3][4][5][6] Given the multitude of studies showing mixed results, we sought to perform a systematic review and meta-analysis of studies evaluating the association of prostate inflammation in PNB and the diagnosis of PCa among adult males. We hypothesize that any inflammation (chronic or acute) on PNB is associated with an increased risk of PCa diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Inflammation on Prostate Needle Biopsy is Associated with Lower Prostate Cancer Risk: A Meta-Analysis

et al. 2018

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“…In a Finnish prostate cancer screening trial, histologic inflammation in prostate biopsy among men with initially elevated serum prostate-specific antigen (PSA) was not linked to increased risk of prostate cancer [ 17 ]. Additionally, histological inflammatory finding at the initial prostate biopsy was negatively associated with prostate cancer detection in repeat biopsy [ 18 ]. When we consider the aggressiveness of prostate cancer among different ethnicities, African American (AA) men are at a higher risk and carry an aggressive load of disease.…”

Section: Prostate and Inflammationmentioning

confidence: 99%

From Inflammation to Prostate Cancer: The Role of Inflammasomes

Karan

Dubey

2016

Advances in Urology

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Inflammation-associated studies entice specific attention due to inflammation's role in multiple stages of prostate cancer development. However, mechanistic regulation of inflammation inciting prostate cancer remains largely uncharacterized. A focused class of inflammatory regulators known as inflammasomes has recently gained attention in cancer development. Inflammasomes are a multiprotein complex that drives a cascade of proinflammatory cytokines regulating various cellular activities. Inflammasomes activation is linked with infection, stress, or danger signals, which are common events within the prostate gland. In this study, we review the potential of inflammasomes in understanding the role of inflammation in prostate cancer.

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Is histological prostate inflammation in an initial prostate biopsy a predictor of prostate cancer on repeat biopsy?

Abstract: A histological inflammatory finding at the initial prostate biopsy was negatively associated with prostate cancer detection in repeat biopsy. This result could be useful to determine the need for repeat prostate biopsy in patients with persistently elevated prostate-specific antigen.

Cited by 11 publications

References 33 publications

NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer

NOD-like receptors: major players (and targets) in the interface between innate immunity and cancer

Inflammation on Prostate Needle Biopsy is Associated with Lower Prostate Cancer Risk: A Meta-Analysis

From Inflammation to Prostate Cancer: The Role of Inflammasomes

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