Is High-Dose Vitamin C Beneficial for Patients With Sepsis?

Brant, Emily; Angus, Derek C.

doi:10.1001/jama.2019.11643

Cited by 22 publications

(17 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vitamin C deficiency is commonly seen in patients with sepsis [ 67 ]. Furthermore, patients with septic shock have significantly depleted vitamin C levels compared with non-septic patients [ 68 ].…”

Section: The Role Of Vitamin C In Management Of Ards Sepsis Septic mentioning

confidence: 99%

“…Furthermore, patients with septic shock have significantly depleted vitamin C levels compared with non-septic patients [ 68 ]. In fact, there is an inverse correlation between serum level of vitamin C in early sepsis and measures of multi-organ dysfunction [ 67 ]. In addition, vitamin C deficiency in critically ill patients is associated with increased vasopressor requirements, multi-organ failure and increased mortality [ 69 ].…”

Section: The Role Of Vitamin C In Management Of Ards Sepsis Septic mentioning

confidence: 99%

“…Vitamin C has an anti-sepsis effect by reducing inflammatory response and oxidative stress as well as suppressing immunological dysfunction, which are the main pathophysiological mechanisms of sepsis [ 70 ]. Pre-clinical evidence showed that vitamin C supresses excessive cytokine release leading to sepsis-induced organ dysfunction [ 67 ]. Sepsis leads to cellular immunosuppression.…”

Section: The Role Of Vitamin C In Management Of Ards Sepsis Septic mentioning

confidence: 99%

See 2 more Smart Citations

Overview of the possible role of vitamin C in management of COVID-19

2020

View full text Add to dashboard Cite

The mainstay of management of coronavirus disease 2019 (COVID-19) is mainly supportive as to date there is no effective antiviral treatment, apart from remdesivir which has been approved by Food and Drug administration (FDA) for treatment of COVID-19, or vaccine. Supplementation with micronutrients, such as vitamins and minerals, has gained an increasing interest as part of the supportive management of COVID-19. Vitamin C levels in serum and leukocytes are depleted during the acute stage of infection owing to increased metabolic demands. High-dose vitamin C supplement helps to normalise both serum and leukocytes vitamin C levels. Vitamin C has multiple pharmacological characteristics, antiviral, anti-oxidant, anti-inflammatory and immunomodulatory effects, which make it a potential therapeutic option in management of COVID-19. The use of high dose of intravenous vitamin C for management of COVID-19 in China and the United Stated has shown promising results. There were no reported adverse reactions with the short-term use of high dose of vitamin C. Given the fact that vitamin C is cheap, available and safe drug with beneficial effects in management of viral infections and critically ill patients reported in previous clinical trials, it is sensible to add it to COVID-19 management protocol particularly if the current ongoing clinical trials testing the effect of vitamin C in management of COVID-19 show positive results.

show abstract

Section: The Role Of Vitamin C In Management Of Ards Sepsis Septic mentioning

confidence: 99%

Section: The Role Of Vitamin C In Management Of Ards Sepsis Septic mentioning

confidence: 99%

Section: The Role Of Vitamin C In Management Of Ards Sepsis Septic mentioning

confidence: 99%

See 1 more Smart Citation

Overview of the possible role of vitamin C in management of COVID-19

2020

View full text Add to dashboard Cite

show abstract

“…Moreover, VC has been reported to be an alternative therapeutic agent against sepsis [ 11 ]. Clinical investigations have revealed that high doses of intravenous VC may reduce inflammation and vascular injury related to sepsis [ 12 ]. VC has several known pharmacological actions, and VC therapy may reduce inflammatory reaction, oxidative stress and ameliorate endovascular and immunologic dysfunctions [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic targets and signaling mechanisms of vitamin C activity against sepsis: a bioinformatics study

Li¹,

Guo²,

Yu³

et al. 2020

Briefings in Bioinformatics

View full text Add to dashboard Cite

Sepsis is a life-threatening complication of pneumonia, including coronavirus disease-2019 (COVID-19)-induced pneumonia. Evidence of the benefits of vitamin C (VC) for the treatment of sepsis is accumulating. However, data revealing the targets and molecular mechanisms of VC action against sepsis are limited. In this report, a bioinformatics analysis of network pharmacology was conducted to demonstrate screening targets, biological functions, and the signaling pathways of VC action against sepsis. As shown in network assays, 63 primary causal targets for the VC action against sepsis were identified from the data, and four optimal core targets for the VC action against sepsis were identified. These core targets were epidermal growth factor receptor (EGFR), mitogen-activated protein kinase-1 (MAPK1), proto-oncogene c (JUN), and signal transducer and activator of transcription-3 (STAT3). In addition, all biological processes (including a top 20) and signaling pathways (including a top 20) potentially involved in the VC action against sepsis were identified. The hub genes potentially involved in the VC action against sepsis and interlaced networks from the Kyoto Encyclopedia of Genes and Genomes Mapper assays were highlighted. Considering all the bioinformatic findings, we conclude that VC antisepsis effects are mechanistically and pharmacologically implicated with suppression of immune dysfunction-related and inflammation-associated functional processes and other signaling pathways. These primary predictive biotargets may potentially be used to treat sepsis in future clinical practice.

show abstract

“…Since completing enrollment in the VICTAS trial in late 2019, discussions of trials exploring the benefits of therapeutic regimens like the one we tested have broadened. While much focus at the time VICTAS was designed was on the question of the efficacy of HAT, negative trials have stimulated a discussion as to when HAT therapy could be effective [3,4].…”

Section: To the Editorsmentioning

confidence: 99%