Is Herd Immunity Against SARS-CoV-2 a Silver Lining?

Vignesh, Ramachandran; Shankar, Esaki Muthu; Velu, Vijayakumar; Thyagarajan, Sadras Panchatcharam

doi:10.3389/fimmu.2020.586781

Cited by 31 publications

(24 citation statements)

References 59 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even so, high seroprevalence levels may reduce the circulation of the virus due to the higher proportion of non-susceptible individuals. Seroprevalence in Spain is far from reaching the herd immunity threshold for COVID-19 (~82.5%), using the mathematical formula 1–1/R0 and assuming an R0 estimate of 5.7 [ 72 , 73 ]. The herd immunity threshold would mean that the incidence of infection will begin to decline once the proportion of individuals with acquired immunity to SARS-CoV-2 in the population exceeds 82.5%.…”

Section: Discussionmentioning

confidence: 99%

Disparities in the Evolution of the COVID-19 Pandemic between Spanish Provinces

López-Mendoza

Montañés

Moliner-Lahoz

2021

IJERPH

View full text Add to dashboard Cite

Spain experienced a second wave of the COVID-19 pandemic in autumn 2020, which has been approached with different measures by regional authorities. We analyze the presence of convergence in the cumulative incidence for 14 days (CI14) in provinces and self-governing cities. The Phillips–Sul methodology was used to study the grouping of behavior between provinces, and an ordered logit model was estimated to understand the forces that drive creating the different convergence clubs. We reject the presence of a single pattern of behavior in the evolution of the CI14 across territories. Four statistically different convergence clubs and an additional province (Madrid) with divergent behavior are observed. Provinces with developed agricultural and industrial economic sectors, high mobility, and a high proportion of Central and South American immigrants had the highest level of CI14. We show that the transmission of the virus is not homogeneous in the Spanish national territory. Our results are helpful for identifying differences in determinants that could explain the pandemic’s evolution and for formulating hypotheses about the effectiveness of implemented measures.

show abstract

Section: Discussionmentioning

confidence: 99%

Disparities in the Evolution of the COVID-19 Pandemic between Spanish Provinces

López-Mendoza

Montañés

Moliner-Lahoz

2021

IJERPH

View full text Add to dashboard Cite

show abstract

“…22 The threshold varies across different infections. [23][24][25] In Covid-19, it was said that for a vaccine with 100% efficacy and providing life-long protection, we would need 60-75% herd immunity. This required number would be increased if the vaccine efficacy was reduced to 85%; a 75-90% herd immunity would be required.…”

Section: Finding On Other Studiesmentioning

confidence: 99%

Covid-19 Vaccination in Pregnancy: A Systematic Review

Pratama

Wafa

Budi

et al. 2021

Preprint

View full text Add to dashboard Cite

Objective: Pregnancy is a risk factor for severe Covid-19. Looking for safe vaccines that evoke protective maternal and fetal antibody response is important. Methods: We searched from registries (ClinicalTrials.gov, the WHO Clinical Trial Registry, and the EU Clinical Trial Registry) and databases (MEDLINE, ScienceDirect, Cochrane Library, Proquest, and Springer) up until June 20, 2021. Articles were selected based on inclusion and exclusion criteria after duplicates were removed. Infection rate, maternal antibody response, placental antibody transfer, and adverse events were described. This systematic review was performed with quality assessment and semi-quantitative synthesis according to PRISMA guidelines. Results: Twelve observational studies with a total of 40.509 pregnant women included. The mRNA based vaccines (Pfizer-BioNTech and Moderna) can prevent future SARS-CoV-2 infections (p=0.0004). Both vaccines did not affect pregnancy, delivery, and neonatal outcomes. The most commonly encountered adverse reactions are injection-site pain, fatigue, and headache but only transient. Antibody responses were rapid after the prime dose of vaccines. After booster, antibody responses were higher and associated with better placental antibody transfer. Longer intervals between first vaccination dose and delivery were also associated with higher antibody fetal IgG and better antibody transfer ratio. Conclusions: The Pfizer-BioNTech and Moderna vaccines are efficacious for preventing future SARS-CoV-2 infections. These vaccines can be considered as a safe option for pregnancy and their fetus. Two doses of vaccines were recommended for more robust maternal and fetal antibody responses. Longer latency was associated with higher fetal antibody responses.

show abstract

“…Despite unknown mild to moderate side effects of currently developed vaccine against SARS-CoV-2 virus, apart from continue practicing SOPs, availability of an effective vaccine is the only ray of hope in the battle against COVID-19 pandemic. 20 would lead to unnecessary deaths and suffering in the population. Vaccine is the only alternative method.…”

Section: Discussionmentioning

confidence: 99%

Is Covid-19 vaccine truly the miracle drug the world was waiting for?

Fakhir¹,

Hameed²

2021

J. Bahria Univ. Med. Dent. Coll.

View full text Add to dashboard Cite

World is in the middle of COVID-19 pandemic. COVID- 19 was declared as a pandemic by WHO on 11, March 2020.1 Globally 108 million cases have been reported worldwide, claiming the deaths of 2.32 million globally.2 The need for wearing masks, frequent hand washing and social distancing cannot be emphasized more since the surge of this pandemic. Now wearing mask and adopting the social distancing are more of a routine. But these measures are certainly not enough to control the pandemic. Efforts more than this are required.

show abstract

Is Herd Immunity Against SARS-CoV-2 a Silver Lining?

Cited by 31 publications

References 59 publications

Disparities in the Evolution of the COVID-19 Pandemic between Spanish Provinces

Disparities in the Evolution of the COVID-19 Pandemic between Spanish Provinces

Covid-19 Vaccination in Pregnancy: A Systematic Review

Is Covid-19 vaccine truly the miracle drug the world was waiting for?

Contact Info

Product

Resources

About