Is hemoglobin concentration affected by sepsis in the acute phase?

Jansma, Geertje; Buter, Hanneke; Gerritsen, RT; Boerma, EC

doi:10.1186/cc11948

Cited by 5 publications

(3 citation statements)

References 2 publications

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“…Anemia is frequently described and explained with various pathophysiologic mechanisms in patients with sepsis [27]. In our study, the hemoglobin concentration was lower in the bacteremic group, but with no statistical significance.…”

Section: Discussioncontrasting

confidence: 62%

Association of Systemic Inflammatory Response Syndrome with Bacteremia in Patients with Sepsis

Grozdanovski

Milenkovikj

Demiri

et al. 2019

Prilozi

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The aim of this study was to evaluate the usability of systemic inflammatory response syndrome (SIRS) and commonly used biochemical parameters as predictors for positive blood culture in patients with sepsis. The study included 313 patients aged ≥18 years with severe sepsis and septic shock consecutively admitted in the Intensive Care Unit (ICU) of the University Clinic for Infectious Diseases in Skopje, Republic of North Macedonia. The study took place from January 1, 2011 to December 31, 2017. We recorded demographic variables, common laboratory tests, SIRS parameters, site of infection, comorbidities and Sequential Organ Failure Assessment (SOFA) score. Blood cultures were positive in 65 (20.8%) patients with sepsis. Gram-positive bacteria were isolated from 35 (53.8%) patients. From the evaluated variables in this study, only the presence of four SIRS parameters was associated with bacteremia, finding that will help to predict bacteremia and initiate early appropriate therapy in septic patients.

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Section: Discussioncontrasting

confidence: 62%

Association of Systemic Inflammatory Response Syndrome with Bacteremia in Patients with Sepsis

Grozdanovski

Milenkovikj

Demiri

et al. 2019

Prilozi

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“…Hasil penelitian ini berbeda dengan penelitian oleh Jansma et al (2013), yang bertujuan mengobservasi perbedaan konsentrasi hemoglobin pada pasien dengan sepsis fase akut dan pasien yang tidak mengalami sepsis di ruang rawat intensif. Jansma mendapatkan konsentrasi hemoglobin pada pasien yang mengalami infeksi bakteri sistemik (sepsis) fase akut lebih rendah daripada pasien yang tidak mengalami sepsis.…”

Section: Pembahasanunclassified

“…Jansma mendapatkan konsentrasi hemoglobin pada pasien yang mengalami infeksi bakteri sistemik (sepsis) fase akut lebih rendah daripada pasien yang tidak mengalami sepsis. 23 Kekurangan folat terutama menyebabkan gangguan metabolisme DNA yang mengakibatkan perubahan morfologi sel terutama sel-sel yang sangat cepat membelah seperti sel darah merah, sel darah putih, serta sel epitel lambung dan usus. Cobalamin atau vitamin B12 merupakan satu-satunya vitamin yang disintesis oleh mikroorganisme dan hanya beberapa bakteri yang memiliki kemampuan untuk memproduksinya serta kebanyakan terdapat pada makanan yang berasal dari hewan seperti daging, ikan, dan telur.…”

Section: Pembahasanunclassified

Probiotik Meningkatkan Konsentrasi Hemoglobin Pada Tikus Putih Yang Diinduksi Lipopolisakarida Escherichia Coli

Sari

Wihastuti

Ardiansyah³

2018

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AbstrakInfeksi bakteri Escherichia coli (E. coli) dapat menyebabkan gangguan sistem hematologi, di antaranya berupa penurunan konsentrasi hemoglobin. Konsumsi probiotik dianggap sebagai salah satu upaya untuk meningkatkan sintesis hemoglobin. Penelitian ini bertujuan untuk mengetahui pengaruh Lactobacillus spp. terhadap konsentrasi hemoglobin pada tikus putih (Rattus norvegicus) yang diinduksi oleh lipopolisakarida (LPS) E. coli. Rancangan penelitian ini adalah true experimental dengan desain randomized post test only control group. Dua puluh satu ekor tikus putih dibagi ke dalam tiga kelompok yaitu: (1) kelompok tikus tanpa perlakuan sebagai kontrol negatif (n = 7), (2) kelompok tikus yang diinduksi LPS E. coli (n = 7), dan (3) kelompok tikus yang dipapar Lactobacillus spp. dan diinduksi LPS E. coli (n = 7). Konsentrasi hemoglobin diukur dengan metode oksihemoglobin. Hasil penelitian menunjukkan perbedaan konsentrasi hemoglobin antara kelompok tikus dengan paparan probiotik dan diinduksi LPS E. coli (8,9±0,3 mmol/L) dibandingkan dengan kelompok kontrol negatif (8,0±0,8 mmol/L), dan kelompok yang hanya diinduksi LPS E. coli (8,4±0,5 mmol/L) (p < 0,05). Disimpulkan bahwa Lactobacillus spp. dapat meningkatkan konsentrasi hemoglobin pada tikus putih yang diinduksi LPS E. coli. AbstractInfection caused by E. coli may lead to a hematological system disorder, such as decreasing of hemoglobin concentration. Consumption of probiotic was considered as an effort to improve hemoglobin synthesis. This study aimed to assess the effect of Lactobacillus spp. on hemoglobin concentration in rats (Rattus norvegicus) induced by lipopolysaccharide (LPS) of E. coli. A true experimental research with randomized post test only control group design was performed. Twenty one rats were divided into three groups including: (1) a negative control (n = 7), (2) a group was induced with LPS of E. coli (n = 7), and (3) a group was exposed to Lactobacillus spp. prior to induction by LPS of E. coli (n = 7). Hemoglobin concentration was measured by oxyhemoglobin method. The results showed the difference of hemoglobin concentration among groups of rat exposed to Lactobacillus spp prior to induction by LPS of E. coli (8,9±0,3 mmol/L), control negative group (8,0±0,8 mmol/L), and group of rat induced by LPS E. coli (8,4±0,5 mmol/L) (p < 0,05). It is concluded that Lactobacillus spp. can increase the hemoglobin concentration in rats induced by LPS of E. coli.

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Multiplex cytokine analyses in dogs with pyometra suggest involvement of KC-like chemokine in canine bacterial sepsis

Karlsson

Hagman

Johannisson

et al. 2016

Veterinary Immunology and Immunopathology

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Is hemoglobin concentration affected by sepsis in the acute phase?

Cited by 5 publications

References 2 publications

Association of Systemic Inflammatory Response Syndrome with Bacteremia in Patients with Sepsis

Association of Systemic Inflammatory Response Syndrome with Bacteremia in Patients with Sepsis

Probiotik Meningkatkan Konsentrasi Hemoglobin Pada Tikus Putih Yang Diinduksi Lipopolisakarida Escherichia Coli

Multiplex cytokine analyses in dogs with pyometra suggest involvement of KC-like chemokine in canine bacterial sepsis

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