Is Helicobacter pylori infection a critical risk factor for vascular dementia?

Xu, Yuzhen; Wang, Qian; Liu, Yunling; Cui, Ruiting; Zhao, Yuwu

doi:10.3109/00207454.2015.1081387

Cited by 30 publications

(20 citation statements)

References 26 publications

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“…The results of the present study are in agreement with previous research indicating the association between H. pylori and dementia or neurodegenerative disorders [3-5, 7, 15, 35]. H. pylori infection is associated with higher risk of Alzheimer's disease, vascular dementia, Parkinson's disease, and neuromyelitis optica [14,[36][37][38][39][40][41][42]. However, the contribution of H. pylori to the development of neurodegeneration showing speci c topography of cortical thinning, was not previously reported.…”

Section: Discussionsupporting

confidence: 93%

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Park

Kim

Song

et al. 2020

Preprint

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Background An association between Helicobacter pylori (H. pylori) infection and dementia was reported in previous studies, however, the evidence is inconsistent. In the present study, the association between H. pylori infection and brain cortical thickness as a biomarker of neurodegeneration was investigated. Methods A cross-sectional study of 1,446 healthy adults who underwent a medical health check-up, including an esophagogastroduodenoscopy and 3.0 T magnetic resonance imaging was performed. H. pylori infection status was assessed based on histology. Multiple linear regression analysis was conducted to evaluate the relationship between H. pylori infection and brain cortical thickness. Results Males with H. pylori infection exhibited cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas compared with non-infected males after controlling for age, educational level, alcohol intake, smoking status, and intracranial volume. The association remained significant after further adjusting for inflammatory marker (C-reactive protein) and metabolic factors (obesity, dyslipidemia, fasting glucose, and blood pressure). However, an association between H. pylori infection and brain cortical thickness was not observed in females. Conclusions The findings indicate H. pylori infection is associated with neurodegenerative changes in cognitive normal males, independent of chronic inflammation or metabolic syndrome.

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Section: Discussionsupporting

confidence: 93%

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Park

Kim

Song

et al. 2020

Preprint

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“…H. pylori with CagA may induce significant increases in serum CRP and IL-6 levels 68 . In addition, H. pylori infection might increase the expression of IL-1β, IL-6 and TNF-α 69 . A study that produced contradictory results confirmed that serum IL-6 levels were not affected by H. pylori eradication in H. pylori -positive subjects 70 .…”

Section: Discussionmentioning

confidence: 99%

The Correlation and Risk Factors between Carotid Intima-Media Thickening and Alcoholic Liver Disease Coupled with Helicobacter pylori Infection

Wang

Jia

et al. 2017

Sci Rep

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The aim of this study was to explore the associations and differences in influencing factors between alcoholic liver disease (ALD) coupled with Helicobacter pylori infection and atherosclerosis and to determine whether there is a “double hit phenomenon” in atherosclerosis patients with ALD and H. pylori infections. Included cases (n = 160) were categorized into 4 groups: 41 cases of ALD coupled with H. pylori infections (group A), 35 cases of H. pylori infections without ALD (group B), 37 cases of ALD without H. pylori infections (group C), and 47 normal control cases (group D). CIMT was significantly greater in group A than in groups B and D (P = 0.005 and P = 0.001, respectively). The GLM univariate analysis found that CIMT was significantly greater in group A than in groups B, C and D (P = 0.018, P = 0.001 and P = 0.009, respectively). We found that BMI and ALT, AST and ApoB levels were independent predictors of CIMT (P = 0.000, P = 0.000, P = 0.012 and P = 0.014, respectively). ALD coupled with H. pylori infection may result in significant CIMT thickening, but H. pylori infection without ALD and ALD without H. pylori infection does not, suggesting that a “double hit phenomenon” occurs. Additionally, BMI, and ALT, AST and ApoB levels were independent risk factors for increased CIMT.

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“…Most of these studies were conducted on patients with the age of 60‐years and above (Shindler‐Itskovitch, Ravona‐Springer, Leibovitz, & Muhsen, ). This is likely because of the chronic inflammation in both the diseases, cross‐linking each other (Xu, Wang, Liu, Cui, & Zhao, ). Consequently, elevated levels of serum YKL‐40 (also known as chitinase‐3‐like protein 1 [CHI3L1]) are a significant marker for many inflammatory diseases, including neurodegenerative ones, such as Alzheimer's (Muszyński, Groblewska, Kulczyńska‐Przybik, Kułakowska, & Mroczko, ).…”

Section: Neurological Disordermentioning

confidence: 99%

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

Zendehdel

Roham

2020

Molec Gen & Gen Med

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This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. AbstractHelicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Elderly people tend to resist eradication treatment and worsening of infection can lead to several gastric and non-gastric pathologies.Aging-associated cellular and molecular alteration can increase the risk of other pathologies such as osteoporosis, Alzheimer's disease, Parkinson's disease, respiratory and renal dysfunction, and cancer in geriatric patients, more than other age groups.This review article highlights some of the most common old age diseases and the role of H. pylori infection as a risk factor to worsen the conditions, presented by the molecular evidences of these associations. These studies can help clinicians to understand the underlying pathogenesis of the disease and identify high-risk patients, aiding clearer diagnosis and treatment.

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Is Helicobacter pylori infection a critical risk factor for vascular dementia?

Abstract: Hp infection might contribute, at least in part, to the cognitive decline in patients with VD, and play a critical role possibly through increasing expression of IL-1β, IL-6 and TNF-α.

Cited by 30 publications

References 26 publications

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

The Correlation and Risk Factors between Carotid Intima-Media Thickening and Alcoholic Liver Disease Coupled with Helicobacter pylori Infection

Role of Helicobacter pylori infection in the manifestation of old age‐related diseases

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