Is heart rate variability associated with frequency and intensity of vasomotor symptoms among healthy perimenopausal and postmenopausal women?

Guthrie, Katherine A.; LaCroix, Andrea Z.; Sternfeld, Barbara; Landis, Clark R.; Reed, Susan D.; Dunn, Andrea L.; Caan, Bette J.; Cohen, Lee S.; Hunt, Julie R.; Newton, Katherine M.

doi:10.1007/s10286-015-0322-x

Cited by 10 publications

(7 citation statements)

References 22 publications

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“…4–6 However, prior research has not found relationships between resting parasympathetic activity and hot flash frequency or severity among midlife women. 9,12 In the current study, there was evidence of an association between cardiac parasympathetic activation and frequency or severity of hot flashes at baseline and over 12 weeks. These findings are intriguing in that they suggest that resting parasympathetic activation play a more important role in women’s experience of hot flashes than has previously been suggested.…”

Section: Discussionsupporting

confidence: 47%

“…Subsequently, an analysis of similar heart rate variability measurements in a recent, large, multicenter hot flash trial network found that these measures did not differentiate hot flash experience or intensity among women with hot flashes at baseline, nor were they correlated with changes in hot flashes in response to treatment. 12 Nevertheless, all of the above studies were limited by reliance on measures that are not pure markers of sympathetic activity.…”

Section: Discussionmentioning

confidence: 99%

“…4–6 In contrast, evidence linking resting autonomic function to hot flashes is mixed, with some studies reporting differences in cardiac markers of sympathetic or parasympathetic activation among women with and without hot flashes, 9 but others finding no relationship of autonomic function to hot flash frequency 10,11 or severity. 12 Overall, interpretability of this small literature is limited by varied definitions and measurement of both hot flashes and markers of autonomic function, and small and homogenous samples in some studies. As a result, the role of both sympathetic and parasympathetic activation in the pathophysiology of hot flashes remains unclear.…”

Section: Introductionmentioning

confidence: 99%

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Cardiac autonomic function and hot flashes among perimenopausal and postmenopausal women

Gibson

Mendes²,

Schembri

et al. 2017

Menopause

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Objective Abnormalities in autonomic function are posited to play a pathophysiologic role in menopausal hot flashes. We examined relationships between resting cardiac autonomic activity and hot flashes in peri- and postmenopausal women. Methods Autonomic function was assessed at baseline and 12 weeks among peri- and postmenopausal women (n=121, mean age=53) in a randomized trial of slow-paced respiration for hot flashes. Pre-ejection period (PEP), a marker of sympathetic activation, was measured with impedance cardiography. Respiratory sinus arrhythmia (RSA), a marker of parasympathetic activation, was measured with electrocardiography. Participants self-reported hot flash frequency and severity in 7-day symptom diaries. Analysis of covariance models were used to relate autonomic function and hot flash frequency and severity at baseline, and to relate changes in autonomic function to changes in hot flash frequency and severity over 12 weeks, adjusting for age, body mass index, and intervention assignment. Results PEP was not associated with hot flash frequency or severity at baseline or over 12 weeks (P>.05 for all). In contrast, there was a trend toward greater frequency of moderate-to-severe hot flashes with higher RSA at baseline (β=.43, p=.06), and a positive association between change in RSA and change in frequency of moderate-to-severe hot flashes over 12 weeks (β= .63, p=.04). Conclusion Among peri- and postmenopausal women with hot flashes, variations in hot flash frequency and severity were not explained by variations in resting sympathetic activation. Greater parasympathetic activation was associated with more frequent moderate-to-severe hot flashes, which may reflect increased sensitivity to perceiving hot flashes.

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Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cardiac autonomic function and hot flashes among perimenopausal and postmenopausal women

Gibson

Mendes²,

Schembri

et al. 2017

Menopause

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“…Jones et al 14 analyzed the intensity of menopausal symptoms and HRV and reported a decrease in all HRV indices in both groups of postmenopausal women. Studies with different objectives also reported decreased cardiac autonomic regulation in postmenopausal women 7,9,[16][17][18] .…”

Section: Discussionmentioning

confidence: 99%

“…In domain of time, study evaluated the mean RR, the root mean square of the successive differences (RMSSD) between successive normal RR intervals from the analysis of adjacent RR intervals, and the standard deviation of all normal-to-normal (SDNN) RR intervals. RMSSD index translates parasympathetic modulation 14 . SDNN represents global variability 4,12 .…”

Section: Hrv Analysismentioning

confidence: 99%

Autonomic cardiac modulation in postmenopausal women with dry eye syndrome: a cross-sectional analytical study

Júnior

Carvalho

Norberto

et al. 2021

Rev. Assoc. Med. Bras.

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OBJECTIVE:The aim of this study was to assess cardiac autonomic modulation in postmenopausal women with and without dry eye syndrome (DES) and to identify associations between clinical and socioeconomic factors. METHODS:A cross-sectional study was carried out at the Institute of Ocular Surgery of the Northeast (ICONE), Brazil. Convenience sample of postmenopausal women, over 40 years old, who were divided into two groups: with and without DES. Clinical, sociodemographic, and ophthalmological characteristics of these women were assessed. Capture of RR intervals was performed using a cardio frequency meter. Differences between the groups were analyzed using the Chi-square test, the Student's t test, and the Mann-Whitney test. RESULTS:Women with DES were present in 60.4% (n=58), highest median age (63.5 years, 95%CI 62.0-67.9; p<0.001), median length of time menopause (19 years old, 95%CI 10.4-24.0; p<0.001). There was a difference in the standard deviation of all normalto-normal index between the groups. However, when the differences were adjusted to the clinical model, no association was found between DES and heart rate variability (HRV). CONCLUSIONS:The analysis of cardiac autonomic modulation in postmenopausal women is similar in the presence or absence of DES.Clinical factors, time of menopause, and intensity of symptoms were not associated with HRV indices.

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Heart Rate Variability: A Tool to Explore Autonomic Nervous System Activity in Health and Disease

Vigo

Siri

Cardinali

2018

Psychiatry and Neuroscience Update

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It is accepted that several biological (genetic, physiological), psychological (personality, mood), social (family, work) and ecological (living environment) factors, interact to allow the preservation of quality of life and health. The autonomic nervous system (ANS) is structural and rhythmically interfaced between forebrain, internal and external environments, to regulate energy, matter and information exchanges, thus expressing the bio-psycho-social nature of the individual. During last year's strong evidence has been produced that demonstrate the influence of the ANS into beat to beat fluctuations of cardiac heart period. Stephen Hales was the first in describing the association between respiratory cycle and heart rate. However, it was not until the second half of the XX century that subtle relations between ANS activity and heart rate variability (HRV) were systematically explored in several physiological conditions, including physical activity, sleep and stress. In addition, autonomic imbalance may configure a final common pathway to increased morbidity and mortality from a host of physical, such as metabolic disorders and cardiovascular disease, and psychological conditions, like anxiety or depression. This chapter will focus on the physiological mechanisms underlying HRV, the methods for assessing it and the information that has provided about ANS activity in certain physiological and pathological situations.

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Is heart rate variability associated with frequency and intensity of vasomotor symptoms among healthy perimenopausal and postmenopausal women?

Cited by 10 publications

References 22 publications

Cardiac autonomic function and hot flashes among perimenopausal and postmenopausal women

Cardiac autonomic function and hot flashes among perimenopausal and postmenopausal women

Autonomic cardiac modulation in postmenopausal women with dry eye syndrome: a cross-sectional analytical study

Heart Rate Variability: A Tool to Explore Autonomic Nervous System Activity in Health and Disease

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