Is Handedness at Five Associated with Prenatal Factors?

Fagard, Jacqueline; Agostini, Maria De; Huet, Viviane; Granjon, Lionel; Heude, Barbara

doi:10.3390/ijerph18073529

Cited by 8 publications

(4 citation statements)

References 79 publications

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“…Parental LH was strongly predictive of LH in their twin offspring, which was not the case for MH. These results also are consistent with earlier reports (Fagard et al, 2021; Johnston et al, 2013; Zhu et al, 2009). Consistent with the meta-analysis of handedness in twins, we observed comparable prevalence of MH in twins, that is, 1.33% versus 2.67% in singletons (Pfeifer et al, 2022).…”

Section: Discussionsupporting

confidence: 94%

Handedness and 23 Early Life Characteristics in 37,495 Dutch Twins

et al. 2023

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In studies of singletons, a range of early-life characteristics have been reported to be associated with handedness, but some of these associations have failed to replicate. We examined associations between 23 early life characteristics with handedness in a large sample of 37,495 5-year-old twins. We considered three definitions of handedness: left-handedness (LH), mixed-handedness (MH), and non-right-handedness (NRH). Our main aim was to test whether the associations with sex, birth weight, gestational age, and season of birth — as reported in singletons — replicate in twins, and to examine twin-specific variables, including zygosity, chorionicity, birth order, and intertwin delivery time. Compared to previously published data from adults born as singletons (7.23%), the prevalence of NRH was higher in both twins (16.19%) and their parents (15.09%). In the twins, LH and NRH were associated with parents’ LH. Male sex and lower gestational age were associated with NRH, and LH was associated with not being breastfed. MH was related to neurodevelopmental delays and higher externalizing problems later in childhood. Other previously reported associations were not replicated, and no twin-specific characteristics were related to handedness. These results emphasize the importance of considering multiple definitions of handedness and indicate a small number of replicated associations across studies.

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Section: Discussionsupporting

confidence: 94%

Handedness and 23 Early Life Characteristics in 37,495 Dutch Twins

et al. 2023

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“…Nevertheless, it has been reported that additive genetic effects only accounts for a quarter of the variance in handedness (Medland et al, 2009), therefore this left-hander-selection-choice is somewhat arbitrary. However, recent studies reported that paternal non-right-handedness was significantly related to left-hand preference in children (van Heerwaarde et al, 2020;Fagard et al, 2021). In our study, all the selected left-handers appeared to have a left-handed father, comforting our criteria choice.…”

Section: How To Study Cortical Foldingsupporting

confidence: 70%

Shape variability of the central sulcus in the developing brain: a longitudinal descriptive and predictive study in preterm infants

Vareilles

Rivière

Sun

et al. 2021

Preprint

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Despite growing evidence of links between sulcation and function in the adult brain, the folding dynamics, occurring mostly before normal-term-birth, is vastly unknown. Looking into the development of cortical sulci in babies can give us keys to address fundamental questions: what is the sulcal shape variability in the developing brain? When are the shape features encoded? How are these morphological parameters related to further functional development?In this study, we aimed to investigate the shape variability of the developing central sulcus, which is the frontier between the primary somatosensory and motor cortices. We studied a cohort of 71 extremely preterm infants scanned twice using MRI – once around 30 weeks post-menstrual age (w PMA) and once at term-equivalent age, around 40w PMA –, in order to quantify the sulcus’s shape variability using manifold learning, regardless of age-group or hemisphere. We then used these shape descriptors to evaluate the sulcus’s variability at both ages and to assess hemispheric and age- group specificities. This led us to propose a description of ten shape features capturing the variability in the central sulcus of preterm infants. Our results suggested that most of these features (8/10) are encoded as early as 30w PMA. We unprecedentedly observed hemispheric asymmetries at both ages, and the one captured at term-equivalent age seems to correspond with the asymmetry pattern previously reported in adults. We further trained classifiers in order to explore the predictive value of these shape features on manual performance at 5 years of age (handedness and fine motor outcome). The central sulcus’s shape alone showed a limited but relevant predictive capacity in both cases. The study of sulcal shape features during early neurodevelopment may participate to a better comprehension of the complex links between morphological and functional organization of the developing brain.Highlights-Shape features can be isolated to describe quantitatively the development of the central sulcus.-Most shape characteristics of the central sulcus are already encoded at 30 weeks of post-menstrual age (w PMA) in preterm newborns.-The central sulcus shows subtle hemispheric asymmetries as soon as 30w PMA.-The early shape of the central sulcus can help predicting handedness and fine motor outcome at 5 years of age.

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“…Although several genes have been associated with it (McManus et al 2013), human handedness has been shown to be influenced by a number of environmental and cultural factors (e.g. Fagard and Dahmen 2004;Ocklenburg et al 2010;Fagard et al 2021), including parental influence (Laland 2008). Studies have proposed hypotheses on the role of human domestication in shaping dogs' cognition, behaviour, and sociability (Range et al 2019;Lazzaroni et al 2020).…”

Section: Introductionmentioning

confidence: 99%

Does owner handedness influence paw preference in dogs?

Charlton

Frasnelli

2022

Anim Cogn

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Handedness has proven to be the most effective and least intrusive measure of laterality in many species. Several studies have investigated paw preference in dogs (Canis familiaris) without considering the potential impact that owner’s handedness may have on it, despite dogs being a domesticated species. The aim of this study was to investigate whether owner handedness influences paw preference in their dogs. Sixty-two dogs had their paw preference tested using a Paw Task and a Reach Task in their home over 10 days, recorded by their owners. Interestingly, it was found that left-handed owners were more likely to own a dog with a left paw bias, and right-handed owners were more likely to own a dog with a right paw bias. In the Paw Task, the hand presented to a dog did not significantly predict which paw the dog lifted in response. Furthermore, it was found that females displayed a right paw bias at all age groups. However, males had a left paw bias in puppyhood and right paw bias in older age groups. We conclude that owner handedness influences paw preference in dogs, and it should be considered when suitably pairing dogs to potential owners, especially in assistance work.

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Is Handedness at Five Associated with Prenatal Factors?

Cited by 8 publications

References 79 publications

Handedness and 23 Early Life Characteristics in 37,495 Dutch Twins

Handedness and 23 Early Life Characteristics in 37,495 Dutch Twins

Shape variability of the central sulcus in the developing brain: a longitudinal descriptive and predictive study in preterm infants

Does owner handedness influence paw preference in dogs?

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