Is Gross Total Resection Reasonable in Adults with Craniopharyngiomas with Hypothalamic Involvement?

Apra, Caroline; Enachescu, C.; Lapras, V.; Raverot, Gérald; Jouanneau, Emmanuel

doi:10.1016/j.wneu.2019.06.037

Cited by 25 publications

(16 citation statements)

References 10 publications

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“…Surgical treatment may damage the optic chiasma and hypothalamus-pituitary axis, so surgeons need enough experience and good surgical skills to complete the operation. At present, there are many surgical methods, whether radical surgery or limited surgery, with an emphasis on protecting the hypothalamus and visual integrity and quality of life after treatment (9)(10)(11)(12). When surgeons are experienced and consider the highest recurrencefree survival (13), safe gross-total resection remains the goal (14).…”

Section: Discussionmentioning

confidence: 99%

Status Quo and Research Trends of Craniopharyngioma Research: A 10-Year Bibliometric Analyses (From 2011 to 2020)

Yang

Liu

et al. 2021

Front. Oncol.

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BackgroundCraniopharyngioma (CP) is a challenging intracranial tumor due to its special hypothalamus-pituitary location. Each patient with CP should be evaluated and treated separately. Exploring novel methods of automatized analysis of data for gaining knowledge on any medical field is an encouraging task, particularly in such an extremely challenging tumor as CP. We aim to summary the situations, investigate the research trends and evaluate research hotspots using bibliometric analysis for the CP research.MethodsWe extracted all the CP-related literatures from 2011 to 2020 from the Web of Science database. An Online analysis platform of literature metrology (Bibliometric), BICOMB, gCLUTO and CiteSpace softwares were used to do bibliometric analysis. As a supplement, we also analyzed the top 100 cited case reports with particular and certainly infrequent information to improve the analysis.ResultsAccording to our retrieval strategy, we found a total of 1262 CP-related literatures. The United States has maintained a leading position in global CP research, followed by China and Germany. Among institutions, Capital Med Univ, St Jude Childrens Res Hosp and Southern Med Univ rank in the top 3 in terms of the number of articles published. “WORLD NEUROSURGERY” is the most popular journal for CP-related research. Moreover, MULLER HL, MERCHANT TE, QI ST and others have made great achievements in the study of CP. Finally, we did biclustering analysis on keywords and identified 4 CP research hotspot clusters.ConclusionsOur research provides a comprehensive analysis of the scientific progress of CP in the past 10 years, and insight into the development of CP research field, highlight research trends over time, and help identify valuable future directions.

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Section: Discussionmentioning

confidence: 99%

Status Quo and Research Trends of Craniopharyngioma Research: A 10-Year Bibliometric Analyses (From 2011 to 2020)

Yang

Liu

et al. 2021

Front. Oncol.

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“…Despite CPs being classified as low-grade neoplasms (Grade I, WHO), they show an aggressive local behavior and a high rate of recurrence (i.e., from 9 to 62%), requiring multimodal invasive treatments to achieve tumor control (1,2,(4)(5)(6). The involvement of the third ventricle is a critical factor increasing long-term morbidity and limiting the effectiveness of surgery and/or radiotherapy (5,(7)(8)(9)(10)(11). Pascal and Prieto (8,12,13) classified CPs topographically into four categories based on their relationship with third ventricular floor: Suprasellar (SS) or pseudo-intraventricular, SS secondary intraventricular, infundibular-tuberal or not strictly intraventricular and ''purely" intra-ventricular tumors.…”

Section: Introductionmentioning

confidence: 99%

“…The surgical resection of intraventricular and/or giant CPs is particularly challenging due to the frequent third ventricular floor invasion and narrow surgical corridors (4,9,(12)(13)(14). Although in some cases the third ventricle portion can be safely resected, ventricular remnants are frequent after surgery, require adjuvant radiotherapy, and increase the risk of long-term recurrence and morbidity (10).…”

Section: Introductionmentioning

confidence: 99%

Neoadjuvant B-RAF and MEK Inhibitor Targeted Therapy for Adult Papillary Craniopharyngiomas: A New Treatment Paradigm

et al. 2022

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BackgroundSurgical and clinical management of craniopharyngiomas is associated with high long-term morbidity especially in the case of hypothalamic involvement. Improvements in knowledge of craniopharyngioma molecular biology may offer the possibility of safe and effective medical neoadjuvant treatments in a subset of patients harboring papillary subtype tumors with a BRAFV600E mutation.MethodWe report herein two cases of tubero-infundibular and ventricular Papillary Craniopharyngiomas in which BRAF/MEK inhibitor combined therapy was used as adjuvant (Case 1) or neoadjuvant (Case 2) treatment, with a 90% reduction in tumor volume observed after only 5 months. In Case 2 the only surgical procedure used was a minimal invasive biopsy by the trans-ventricular neuroendoscopic approach. As a consequence, targeted therapy was administered in purely neoadjuvant fashion. After shrinkage of the tumor, both patients underwent fractionated radiotherapy on the small tumor remnant to achieve long-term tumor control. A review of a previously reported case has also been performed.ResultThis approach led to tumor control with minimal long-term morbidity in both cases. No side effects or complications were reported after medical treatment and adjuvant radiotherapy.ConclusionOur experience and a review of the literature argue for a change in the current treatment paradigm for Craniopharyngiomas (CPs). In giant and invasive tumors, confirmation of BRAFV600E mutated PCPs by biopsy and BRAF/MEK inhibitor therapy before proposing other treatments may be useful to improve long term outcomes for patients.

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“…However, CPs are prone to local invasion and adherence to adjacent neurovascular tissues and thus, total removal of the tumors is frequently incomplete [ 7 , 8 ]. Furthermore, surgery might result in significant comorbidities particularly if gross total removal is attempted [ 8 , 9 ]. All of these factors contribute to the increased morbidity and overall mortality seen in CP patients [ 1 , 8 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Sex Hormone Receptor Expression in Craniopharyngiomas and Association with Tumor Aggressiveness Characteristics

Martínez-Ortega

Flores-Martinez

Dios

et al. 2022

JCM

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Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they display a relatively high recurrence rate that might compromise quality of life. Previous studies have reported that CPs express sex hormone receptors, including estrogen and progesterone receptors. Here, we systematically analyzed estrogen receptor α (ERα) and progesterone receptor (PR) expression by immunohistochemistry in a well-characterized series of patients with CP (n = 41) and analyzed their potential association with tumor aggressiveness features. A substantial proportion of CPs displayed a marked expression of PR. However, most CPs expressed low levels of ERα. No major association between PR and ERα expression and clinical aggressiveness features was observed in CPs. Additionally, in our series, β-catenin accumulation was not related to tumor recurrence.

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Is Gross Total Resection Reasonable in Adults with Craniopharyngiomas with Hypothalamic Involvement?

Cited by 25 publications

References 10 publications

Status Quo and Research Trends of Craniopharyngioma Research: A 10-Year Bibliometric Analyses (From 2011 to 2020)

Status Quo and Research Trends of Craniopharyngioma Research: A 10-Year Bibliometric Analyses (From 2011 to 2020)

Neoadjuvant B-RAF and MEK Inhibitor Targeted Therapy for Adult Papillary Craniopharyngiomas: A New Treatment Paradigm

Sex Hormone Receptor Expression in Craniopharyngiomas and Association with Tumor Aggressiveness Characteristics

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