Is Gout Associated with Pyoderma Gangrenosum? A Population-Based Case-Control Study

Abstract

The coexistence of pyoderma gangrenosum (PG) and gout has been reported in individual patients; however, the association between these conditions has not been investigated. We aimed to assess the association between PG and gout and to examine whether the presence of gout predisposes to the development of PG. A population-based case-control study was conducted comparing PG patients (n = 302) with age-, sex-, and ethnicity-matched control subjects (n = 1497) with respect to the presence of preceding gout. Logistic regression models were utilized for univariate and multivariate analyses. The prevalence of preceding gout was greater in patients with PG than in control subjects (3.7% vs. 0.7%, respectively; p < 0.001). Gout was associated with a more than fivefold increase in the risk of PG (OR, 5.15; 95% CI, 2.21–11.98). After adjusting for confounding factors, gout emerged as a significant independent predictor of PG (adjusted OR, 4.08; 95% CI, 1.69–9.80). Gout preceded the diagnosis of PG by a median latency of 4.6 years. Patients with gout-associated PG were older, predominantly male, and had a higher prevalence of metabolic syndrome than other patients with PG. In conclusion, gout increases the risk of developing PG by more than fivefold. Physicians managing patients with gout and PG should be aware of this emerging association.

Sexuality, Quality of Life, Anxiety, Depression, and Anger in Patients with Anal Fissure. A Case–Control Study

“…Previous studies have focused on the relationship between medical diseases or mental disorders including its treatments and patients sexuality, QoL (general or health related), or selected psychological factors highlighting the relationship between these factors and clinical disorders or its treatments [ 5 , 10 , 11 , 13 , 14 , 15 , 19 , 20 , 23 , 25 , 29 , 34 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 ]. These include, sex and quality of life [ 10 ]; sexual health and dysfunction in patients with rheumatoid arthritis [ 13 ]; sexuality and mental health [ 15 ]; antipsychotic-related sexual dysfunction [ 19 ]; sexual function in chronic illness [ 20 ]; the impact of physical illness on sexual dysfunction [ 23 ]; sexual dysfunction and chronic illness [ 27 ]; sex and chronic physical illness [ 28 ]; comorbidities in male and female sexual dysfunction [ 60 ]; sexual dysfunction and mental health in patients with multiple sclerosis and epilepsy [ 29 ]; psychiatric disorders and sexual dysfunction [ 63 ]; thyroid autoimmune disease impacting on sexual function in young women [ 64 ]; clinical features associated with female genital mutilation/cutting [ 65 ]; QoL after flatfoot surgery [ 33 ]; anxiety and QoL in patients with type 2 diabetes [ 58 ]; QoL and associated psychological distress in patients with knee arthroplasty [ 59 ]; psychological factors as determinants of medical conditions [ 57 ]; sleep disturbance, depression and anxiety in frail patients with atrial fibrillation [ 61 ]; cognitive behavior counseling in preoperative preparation and enhanced recovery after surgery [ …”

“…This case–control study [ 32 , 33 , 34 ] was carried out from January 2016 to February 2017 [ 3 ]. Cases were defined as patients diagnosed with acute or chronic idiopathic AFs during the study period who wished to participate in the study and provided written informed consent for this purpose.…”

Risk of solid malignancies in bullous pemphigoid: A large‐scale population‐based cohort study

“…CHS is the largest health‐care maintenance organization in Israel, providing a wide array of private and public health‐care services for 4 540 768 enrollees as of October 2018. The different characteristics of the utilized dataset are detailed in other publications 7,8 …”

The Nature of Race in Germany: A systematic literature review of human classifications in German life sciences

“…Kridin et al, for example, investigated specific health differences between people with Jewish and Arab ethnicity in Israel. In the discussion section the authors contrasted their results for "patients of Jewish ancestry" with a study on people of "African race", implying that the differentiations of these two studies are comparable (Kridin et al 2020). This kind of switching and equating of human classifications in the discussion of results is not currently covered by the usual journal guidelines.…”