Is Genie Having A Cure For Oral Cancer - Genetic Dentistry

Abstract

Genin oral kanser için bir tedavisi var mı? Genetik diş hekimliği Dünyada en yaygın görülen kanser türleri arasında olan oral karsinom, global olarak en sık görülen altıncı kanserdir. Oral kanser, tütün ve alkol kullanımına bağlı olarak ortaya çıkan genetik mutasyonlarla ilişkilidir. Son yıllarda oral kanser hastalarının cerrahi, radyoterapik ve kemoterapik tedavilerindeki gelişmeler hasta sağkalımında anlamlı gelişmeler yaratmamıştır. İmmunoterapi, gen terapisi ve hedeflenmiş terapideki son gelişmeler oral kanser tedavisinde umut verici sonuçlar ortaya koymaktadır. Gen terapisi çevre dokuda toksik etkiler oluşturmadan hedef hücrelere spesifik genetik materyalin sunulmasını içerir. Günümüzde gen terapisi çalışmalarının çoğu kanser ve genetik bozukluklarla ilişkili kalıtsal hastalıkları hedeflemiştir. Bu derleme oral kanser türlerinde gen terapisi ile yapılmış çalışmaların temel kavram ve çeşitlerine açıklık getirmektedir. Gen terapisi oral kanser tedavisinde öne çıkan yeni çalışma alanlarından biridir. Anahtar sözcükler: Gen terapisi, oral kanser ABS TRACT Is genie having a cure for oral cancer?-genetic dentistry Worldwide, oral carcinoma is one of the most prevalent cancers and it is the sixth most common cancer globally. Oral cancer is associated with genetic mutations which occur due to the exposure to tobacco, alcohol, betel quid. Advances over recent decades in the surgical, radiotherapeutic and chemotherapeutic treatment of oral cancer patients did not produced a significant improvement in patient survival. Recent advances like immunotherapy, gene therapy, and targeted therapy are showing promising results in the management of oral cancer. Gene therapy essentially consists of introducing specific genetic material into target cells without producing toxic effects on surrounding tissue. Today, most of the gene therapy studies are aimed at cancer and hereditary diseases which are linked to genetic defects. This article highlights the basic concept, types and various studies done on oral cancer using gene therapy. Gene therapy has becoming one of the emerging fields in the management of oral cancer.

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