Is first-line antimicrobial therapy still adequate to treat MRSA in the ICU? A report from a highly endemic country

Predictors of Mortality with Staphylococcus aureus Bacteremia in Elderly Adults

“…In our study, prescription of inadequate empirical antibiotic therapy was found to be an independent risk factor for 7‐day mortality in participants aged 75 and older, confirming previously reported data …”

“…In our study, prescription of inadequate empirical antibiotic therapy was found to be an independent risk factor for 7-day mortality in participants aged 75 and older, confirming previously reported data. 12,15 In this setting, a high index of suspicion for MRSA, which in Italy accounts for up to 30% of all the isolates, 16 is crucial for prescription of adequate empirical therapy, particularly in individuals with specific risk factors (e.g., older age, previous MRSA colonization or infection, recent antibiotic treatment, chronic underlying comorbidities, immunosuppression). In our study, MRSA accounted for 39% of isolates overall.…”

The role of methicillin-resistant Staphylococcus aureus in skin and soft tissue infections

“…The burden of MRSA is still more prominent in hospital compared with the community setting [9][10][11]. In recent years, however, MRSA has progressively spread into the community, particularly among outpatients affected by multiple comorbidities and having frequent contact with the healthcare system (e.g.…”