Is excess folic acid supplementation a risk factor for autism?

Beard, C. Mary; Panser, Laurel A.; Katusic, Slavica K.

doi:10.1016/j.mehy.2011.03.013

Cited by 73 publications

(55 citation statements)

References 4 publications

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“…Baura et al [17] identified substantial differently methylated regions (DMRs) in the the cerebral hemispheres of mice offspring of mothers on high folic acid intake as compared to offspring of mice on low maternal folic acid diet. These results support the findings of numerous studies that show that abnormalities in the frontal lobes impact brain development and autism [20][21][22][23][24]. Until very recently, changing the folate status in humans has been shown to influence DNA methylation, but it was not established whether alteration in DNA methylation after changes in folate status are harmful in humans.…”

Section: Dna Methylation and The Epigenetic Role Of Folic Acid In Asdsupporting

confidence: 87%

- A Prospective Study of Nutrition Education and Oral Nutritional Supplementation in Patients with Alzheimer’s Disease

Cox¹

2015

Nutritional Biochemistry

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Abstract:There is considerable scientific evidence that many aspects of diet influence the occurrence of human disease. Many factors such as genetic, psychological, environmental and behavioral characteristics influence development of human disease, and there is a close relationship between nutrition and disease. Though typical Western diets are not overtly deficient in essential nutrients, nutriture of a few micro nutrients such as folic acid has been reported to be sub-optimal, particularly in women of childbearing age. The role of folic acid in the prevention of macrocytic anemia and neural tube defects is well established. However, the relationship between folic acid and risk of autism is still evolving. Furthermore, environmental as well as nutritional factors such as folic acid are now well acknowledged as interacting with the individual genetic background in development of several diseases. In this article, recent research regarding the relationship between folic acid and risk of autism is evaluated.

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Section: Dna Methylation and The Epigenetic Role Of Folic Acid In Asdsupporting

confidence: 87%

- A Prospective Study of Nutrition Education and Oral Nutritional Supplementation in Patients with Alzheimer’s Disease

Cox¹

2015

Nutritional Biochemistry

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“…However, as folic acid fortification has increased, so has the incidence of autism, suggesting another problem. In the United States, it has been reported that the incidence of autism increased after folate fortification (58,59). The Autism Genome Project Consortium noted that the glutamatergic neural system and genes associated with glutamate may contribute to the appearance of autism spectrum disorders (60).…”

Section: Autismmentioning

confidence: 99%

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

Coşar¹,

İpçioğlu²,

Özcan³

et al. 2014

Turk J Med Sci

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This work aims to study recent climatic oscillations and their influence on sedimentation in the Ria de Vigo, a coastal embayment in Galicia, NW Spain. It is based on the study of clay mineral assemblages, in conjunction with other proxies (granulometric, geochemical, geochronological and microfaunal), in the core KSGX 24. A Benthic Foraminifera High Productivity (BFHP) proxy was used to determine changes in the flux of organic matter (OM) at the bottom of the study area. Total organic carbon (TOC) content is not a suitable proxy to estimate changes in the past supply of OM due to diagenetic processes. The sedimentation was finest in 3 sections: ~ 230-214 cm, ~ 185-73 cm and ~ 20-0 cm. These muddy sections are characterised, in general, by higher proportions of detrital minerals, concentrations of several chemical elements related to lithogenic sources and BFHP values. In addition, these sections are impoverished in carbonates, Ca, Sr and La when compared with the layers with the highest sand content. The clay mineral assemblage of the studied site, characterised by the dominance of illite, intermediate concentrations of kaolinite and minor amounts of smectite and chlorite, reveals the prevalence of a typical temperate humid climate in the last 3 ka BP, the estimated age for the core base. However, the quantities of illite and chlorite increase in the muddy layers. The characteristics of these muddy layers were interpreted as representing relatively cold climatic oscillations associated with the strengthening of northerly winds and the prevalence of an upwelling regime corresponding to well-known periods, such as the first cold period of the Upper Holocene (~ 2.9 ka cal BP), the Dark Ages (between ~ 2.2 -1.2 ka cal BP) and the Little Ice Age (~ 0.6 ka cal BP).

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“…[59][60][61] Because the timing and level of folic acid supplementation in the form of prenatal vitamins is critical for the protective effect, these findings and hypotheses may not be in absolute conflict and there is middle ground to be reached with future studies. Perhaps the low-level of folic acid fortification in cereal grains in the diet may select for the survival of fetuses with increased number of repeats and structural duplications compared to previous generations.…”

Section: Interactions Of Genetics and Folic Acid Protection From An Ementioning

confidence: 99%

A genomic point-of-view on environmental factors influencing the human brain methylome

LaSalle

2011

Epigenetics

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Is excess folic acid supplementation a risk factor for autism?

Cited by 73 publications

References 4 publications

- A Prospective Study of Nutrition Education and Oral Nutritional Supplementation in Patients with Alzheimer’s Disease

- A Prospective Study of Nutrition Education and Oral Nutritional Supplementation in Patients with Alzheimer’s Disease

Folate and homocysteine metabolisms and their roles in the biochemical basis of neuropsychiatry

A genomic point-of-view on environmental factors influencing the human brain methylome

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