Is elevated triglyceride high density lipoprotein cholesterol ratio a risk factor that causes acute coronary syndrome to appear earlier?

Doğan, Cem; Bayram, Zübeyde; Karagöz, Ali; Bakal, Ruken Bengi; Erdoğan, Emrah; Yilmaz, Feray; Akbal, Özgür Yaşar; Acar, Rezzan Deniz; Aktemur, Tuğba; Güvendi, Bülent; Karaduman, Ahmet; Hakgör, Aykun; Kaymaz, Ci̇hangi̇r; Özdemir, Nihal

doi:10.4149/bll_2018_140

Cited by 11 publications

(11 citation statements)

References 20 publications

(22 reference statements)

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“…Recently, the TG/HDL-C ratio was also reported to be related to CHD. It has been demonstrated that the TG/HDL-C ratio may be an important predictor for an acute coronary syndrome in the young adult population and can even be used to prevent myocardial infarction in young adults [31]. In the present study, the TG/HDL-C ratio was also significantly higher in young nondiabetic patients with CHD when compared to those without CHD.…”

Section: Discussionsupporting

confidence: 57%

High-Density Lipoprotein Cholesterol in Young Nondiabetic Coronary Heart Disease Patients

Cui

et al. 2021

Cardiology Research and Practice

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Objective. To investigate the association between the lipid profiles and coronary heart disease (CHD) in nondiabetic patients younger than 65 years of age. Method. 424 patients were enrolled in this study from January 2019 to December 2020. All the patients were screened for clinically indicated coronary angiography. They were divided into two groups according to the coronary angiography results: 340 patients with the presence of CHD (at least one coronary artery stenosis ≥50%) were classified as the CHD group, and the rest with the absence of CHD comprised the normal group. The demographic data and lipid profiles were compared. Result. CHD was higher in males than females (84.5% vs. 62.2%, P < 0.001 ). In the CHD group, the level of high‐density lipoprotein cholesterol (HDL-C) was lower P < 0.001 , while the triglyceride (TG)/HDL-C ratio was higher P = 0.022 . No significant differences were shown between the two groups in terms of age, family history of CHD, hypertension, and the levels of TC, TG, and LDL-C. Gender differences were further explored. In men, except for the level of HDL-C which was significantly lower in the CHD group than that in the normal group P = 0.017 , parameters were comparable. A binary logistic regression model further indicated that HDL-C was associated with CHD (OR = 0.137, 95%CI: 0.031–0.594, P = 0.008 ). Also, with the increase of the number of coronary artery with lesions, the levels of HDL-C decreased significantly in men. In women, no differences were observed between the CHD group and normal group. Conclusion. HDL-C may be inversely associated with the risk of CHD in young nondiabetes patients, especially in men. More research is needed to confirm it.

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Section: Discussionsupporting

confidence: 57%

High-Density Lipoprotein Cholesterol in Young Nondiabetic Coronary Heart Disease Patients

Cui

et al. 2021

Cardiology Research and Practice

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“…26 In a study on the association between triglycerides/HDL and acute coronary syndrome, a number of scholars found that increased triglycerides/HDL were associated with the development of AMI in young adults. 27,28 Given the risk factors of young AMI patients, we recommend enhanced screening of patients with a family history of hyperlipidaemia, regular or enhanced follow-up, reasonable management of those at risk with a family history of hyperlipidaemia, and complementary early rehabilitation care interventions to modify risk factors in young patients with the disease. For patients with unhealthy lifestyles, we advise them to manage their lives by reducing the frequency of smoking and alcohol consumption and increasing their intake of vegetables and For patients with abnormal serological indicators, we advise patients to eat a light diet, reduce the intake of fried foods and animal offal, and increase physical activity when used.…”

Section: Discussionmentioning

confidence: 99%

Analysis of clinical characteristics and risk factors of young acute myocardial infarction

He¹,

Tian²,

Xian³

et al. 2022

HSET

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OBJECTIVE: The aim of the study is to investigate the clinical characteristics and risk factors for the development of young acute myocardial infarction (AMI). METHODS: A number of 196 AMI patients (31 young patients and 165 older patients) were enrolled in the study. The clinical characteristics in young AMI patients were explored by comparing their baseline characteristics, imaging features and serological results. The risk factors were tested by logistics regression analysis. RESULTS: The younger AMI patients were more likely to have hyperlipidaemia (67.74% vs. 36.97%, P=0.002), a family history of coronary heart disease and hyperlipidaemia (29.03% vs. 12.12%, P=0.025) (51.61% vs. 18.79%, P<0.001), (54.84% vs. 35.15%, P=0.045) (61.29% vs. 34.55%, P=0.008). The proportion of alcohol and tobacco use were higher in younger AMI group. More severe anterior descending lesions involvement (77.42% vs. 46.06%, P=0.002) and a higher Gensini scores (62.23±16.80) vs. (53.00±18.58), P=0.011) were found in CTA imagines of younger AMI patients. The triglyceride levels were also significantly higher in younger AMI patients (2.55±1.59) vs. (1.67±0.79), P=0.005). A family history of hyperlipidaemia, Gensini score, IL-6 and triglycerides were risk factors for young AMI patients. CONCLUSION: Poor lifestyle management and family history were risk factors for the AMI development in young patients.

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“…In female patients, it has been shown that the TG / HDL-C ratio is independently associated with major cardiovascular events in patients presenting with revascularized STelevation myocardial infarction (10). It has been shown that the TG / HDL-C ratio may be an important predictor for acute coronary syndrome in the young adult population (19). In addition, after a successful revascularization for acute coronary syndrome, TG / HDL-C ratio was determined to be a risk factor for revascularization (20).…”

Section: Discussionmentioning

confidence: 99%

Koroner Arter Hastalığının Öngördürücüleri Olarak Trigliserid Glikoz İndeksi ve Trigliserid / HDL Oranı

Tolunay¹,

Fırtına²

2021

Düzce Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi

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Triglyceride to high density lipoprotein cholesterol (TG/HDL-C) ratio and triglyceride-glucose (TyG) index are simple, reliable screening methods. It has been shown that the TyG index predicts mortality in cardiovascular diseases, and the TG/HDL-C ratio predicts the severity of coronary artery disease (CAD). The aim of this study is to define the relationship between the SYNTAX score, which indicates the severity of CAD, and the TyG index and TG/HDL-C ratio. Material and Methods: A total of 408 patients who underwent coronary angiography were evaluated in this study. TyG index, TG/HDL-C ratio and SYNTAX scores were calculated. Patients were grouped according to their diagnosis and SYNTAX scores. Relationships between TyG index, TG/HDL-C ratio and SYNTAX score were examined. Results: There was a significant relationship between the TyG index and the presence of CAD (p<0.001). TyG index was significantly higher in patients with severe CAD than patients with mild CAD ((8.46±0.54) vs.(8.98±0.67), p=0.045). While there was a significant positive association between TG/HDL-C ratio and the presence of CAD (p<0.001), there was no significant relationship between severity of CAD (p=0.814). The TyG index values of those presenting with ST elevation myocardial infarction were higher than those presenting with stable angina pectoris (p=0.050). Conclusion:The TyG index and TG/HDL-C ratio were predictors of the presence of CAD and the TyG index also provides guidance on the severity of CAD. Standard use may be considered in addition to risk scoring in the diagnosis of CAD and planning coronary angiography.

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Is elevated triglyceride high density lipoprotein cholesterol ratio a risk factor that causes acute coronary syndrome to appear earlier?

Cited by 11 publications

References 20 publications

High-Density Lipoprotein Cholesterol in Young Nondiabetic Coronary Heart Disease Patients

High-Density Lipoprotein Cholesterol in Young Nondiabetic Coronary Heart Disease Patients

Analysis of clinical characteristics and risk factors of young acute myocardial infarction

Koroner Arter Hastalığının Öngördürücüleri Olarak Trigliserid Glikoz İndeksi ve Trigliserid / HDL Oranı

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