Is Dupuytren’s disease an occupational illness?

Murínová, Lenka; Perečinský, Slavomír; Jančová, Andrea; Murín, Pavol; Legáth, Ľ

doi:10.1093/occmed/kqaa211

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Aleksandar et al [4], among patients with diabetes mellitus, the risk is increased by factors such as age, duration of the disease, poor blood glucose control and hypokalaemia. L. Murínová et al [5] note that Dupuytren's contracture can be an occupational disease if it develops after prolonged work with vibrating tools. Alcohol consumption is also a significant risk factor for the development of pathology, unlike smoking [6,7].…”

Section: Methodsmentioning

confidence: 99%

Dupuytren’s contracture treated with collagenase Clostridium histolyticum

Ugurbas

2023

ijmmr

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Treatment of Dupuytren’s contracture improves the quality of life of patients, but standard open fasciectomy surgery is traumatic and requires long-term rehabilitation. The study aimed to determine whether injectable treatment with collagenase preparations was effective in comparison with open fasciectomy. Forty patients were examined. Of these, 15 were treated with Clostridium histolyticum collagenase preparations (the main group), and 25 underwent limited fasciectomy (the control group). In 11 (73.3%) patients of the main group, restoration of mobility of the affected joints was achieved after the first injection, in 3 (20%) – after the second, and in 1 (6.7%) – after the third. Patients in the main group remained able to work after treatment and did not require rehabilitation; the function of the upper limb was fully restored on the day of intervention. During the observation period, 12 (80%) patients in the main group were concerned about dry skin at the intervention site, and 5 (33.3%) patients were concerned about itching and discolouration of the skin at the intervention site. In 25 (100%) patients of the control group, joint mobility was fully restored. The ability to use the hand after surgery in patients of the control group was limited for 6 (4.5; 10) days. All patients in the control group required rehabilitation to relieve stiffness and restore the functional capabilities of the hand. The period of disability in these patients lasted 16 (12; 24.5) days. 11 (44%) patients had complaints of pain or discomfort in the intervention area during the follow-up, and 24 (96%) patients were bothered by itching. Satisfaction with the choice of treatment method in the main group was more frequent compared to the control group. Relapses during the observation period were absent in both groups. Thus, the efficacy of Clostridium histolyticum collagenase preparations are comparable to the results of surgical treatment. Minimally invasive treatment is optimal for patients with mild disease, as well as for those who have a low risk of contracture recurrence. The results of this study can be useful for surgeons when choosing the optimal method of treating Dupuytren’s contracture

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Section: Methodsmentioning

confidence: 99%

Dupuytren’s contracture treated with collagenase Clostridium histolyticum

Ugurbas

2023

ijmmr

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“…Occupation [30,[33][34][35][36][37][38] Occupational daily vibration exposure. Daily heavy manual work.…”

Section: Modifiable Predictor Characteristicsmentioning

confidence: 99%

Modifiable and Non-Modifiable Predictors of Dupuytren’s Disease

Petrov

Medvedev

Pushkin

et al. 2022

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Dupuytren's disease (DD) is a common multifactorial disease accompanied by deformity of the hand with flexion contracture of one or more fingers, limitation of their mobility and a fixed lesion. This disease refers to disorders of the connective tissue. Objective: to generalize the results of studies of environmental risk factors for DD and update existing ideas about modifiable and non-modifiable predictors of the disease in adults. Methods. We searched for full-text English-language publications in the PubMed, Springer, Scopus, Clinical Keys, Oxford Press, Google Scholar, eLIBRARY. Results. The most significant modifiable predictors of the development of DD include (top 5): occupation; hobby; lifestyle; comorbid diseases; drugs. Non-modifiable predictors include (top 5): gender; age; ethnos; race; genetics. Genetic predictors of DD are not well understood, but the number of candidate genes responsible for the development of DD is increasing and reaches the top 50 or more candidate genes with a statistically significant association with the risk of developing DD in adults. The most studied candidate genes are DUPC1, MMP2, MMP9, TIMP1, TIMP2, WNT4, WNT7B. Discussion. Primary and secondary prevention of DD requires accounting of the mutual influence of modifiable and non-modifiable predictors in the disease development, as well as a personalized approach in planning and choosing non-surgical and surgical treatment, as well as the carriage of single nucleotide variants (SNVs) candidate genes associated with the development of DD. A promising direction in the prevention of disabling complications of DD may be the development of decision-making information programs (personalized algorithms) that take into account non-genetic and genetic predictors in a particular person, and their implementation in real clinical practice. Conclusion. Large multicenteral studies of the influence and mutual influence of modifiable and non-modifiable predictors with a single design are required in the future.

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“…Several studies on the association between manual work exposure and Dupuytren's disease show conflicting results. [5][6][7][8][9] Although most publications on this subject report a positive association between manual work and Dupuytren's disease, 3 the majority of these studies were limited by a highly selected or small study population, and the lack of adjustment for important confounders. 10 Obtaining a definitive answer to the question of whether Dupuytren's disease is an occupational disease would give us more insight into its aetiology, and would be of great value in informing preventative strategies.…”

Section: Introductionmentioning

confidence: 99%

Dupuytren’s disease is a work-related disorder: results of a population-based cohort study

et al. 2023

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ObjectivesDupuytren’s disease (DD) is a fibroproliferative disorder of the hands, characterised by the development of fibrous nodules and cords that may cause disabling contractures of the fingers. The role of manual work exposure in the aetiology of DD is controversial. We investigated whether current occupational exposure to manual work is associated with DD, and if there is a dose–response relationship.MethodsIn this population-based cohort analysis, we used data from the UK Biobank cohort. Our primary outcome was the presence of DD. The exposure of interest was manual work, measured for each participant in two different ways to allow two independent analyses to be undertaken: (1) the current manual work status of the occupation at the time of recruitment, and (2) a cumulative manual work exposure score, calculated based on the occupational history. We performed propensity score matching and applied a logistic regression model.ResultsWe included 196 265 participants for the current manual work analysis, and 96 563 participants for the dose–response analysis. Participants whose current occupation usually/always involved manual work were more often affected with DD than participants whose occupation sometimes/never involved manual work (OR 1.29, 95% CI 1.12 to 1.49, p<0.001). There was a positive dose–response relationship between cumulative manual work exposure score and DD. Each increment in cumulative work exposure score increased the odds by 17% (OR 1.17, 95% CI 1.08 to 1.27, p<0.001).ConclusionsManual work exposure is a risk factor for DD, with a clear dose–response relationship. Physicians treating patients should recognise DD as a work-related disorder and inform patients accordingly.

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Is Dupuytren’s disease an occupational illness?

Cited by 6 publications

References 22 publications

Dupuytren’s contracture treated with collagenase Clostridium histolyticum

Dupuytren’s contracture treated with collagenase Clostridium histolyticum

Modifiable and Non-Modifiable Predictors of Dupuytren’s Disease

Dupuytren’s disease is a work-related disorder: results of a population-based cohort study

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