Is directly measured low-density lipoprotein clinically equivalent to calculated low-density lipoprotein?

Baruch, Lawrence; Agarwal, Savita; Gupta, Bhanu; Haynos, Ann F.; Johnson, Swapna; Kelly-Johnson, Katelyn; Eng, Calvin

doi:10.1016/j.jacl.2010.05.003

Cited by 18 publications

(12 citation statements)

References 17 publications

(24 reference statements)

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“…The authors of a recent study reported poor agreement between results calculated with the Friedewald equation and a direct LDL-C assay from Siemens. 17 Despite a good correlation between these methods, more than 25% of results differed by more than 30 mg/dL, 17 leading the authors to conclude that the two methods do not consistently provide similar clinical information.…”

Section: The Friedewald Equationmentioning

confidence: 99%

Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement

Contois

Warnick²,

Sniderman

2011

Journal of Clinical Lipidology

109

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Section: The Friedewald Equationmentioning

confidence: 99%

Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement

Contois

Warnick²,

Sniderman

2011

Journal of Clinical Lipidology

109

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“…Interestingly, a study examining the correlation between 145 pairs of Friedewald-calculated and directly measured LDL-C found that one-third of the measurements had a >15 mg/dl difference and onefourth had a >20 mg/dl difference [19].…”

Section: What Is Non Hdl Cholesterol?mentioning

confidence: 99%

The Importance of Non High Density Lipoprotein Cholesterol in Dyslipidaemia Management

Chowdhury¹,

Chowdhury²

2015

J Diabetes Metab

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Dyslipidaemia is a major contributor to cardiovascular disease which has assumed epidemic proportions worldwide. The traditional approach to the management of dyslipidaemia focusses mainly on LDL cholesterol. However, recent evidence suggests that non HDL-C is an important marker of cardiovascular risk and might play a more important role than LDL cholesterol in the causation of cardiovascular disease. Non HDL cholesterol includes all ApoB containing lipoproteins and can be tested more reliably and conveniently with the available laboratory assays. Inspite of the evidence, the role of non HDL cholesterol in atherosclerosis is underrecognised and this lipid parameter is often undertreated. This review highlights the importance of non HDL cholesterol in dyslipidaemia management, both in diabetics and otherwise.

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“…Direct measurement of LDL-C is not recommended as not all laboratories are able to adequately perform this test and even under ideal conditions, the laboratory coefficient of deviation is often quite large. 67 A recommended panel of laboratory tests for initial evaluation is presented in Box 3.…”

Section: Laboratory Evaluationmentioning

confidence: 99%

Lipid Management in Human Immunodeficiency Virus

Myerson¹

2015

Cardiology Clinics

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Is directly measured low-density lipoprotein clinically equivalent to calculated low-density lipoprotein?

Cited by 18 publications

References 17 publications

Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement

Reliability of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B measurement

The Importance of Non High Density Lipoprotein Cholesterol in Dyslipidaemia Management

Lipid Management in Human Immunodeficiency Virus

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