Is diffusion of SARS-CoV-2 variants of concern associated with different symptoms?

Mattiuzzi, Camilla; Henry, Brandon Michael; Lippi, Giuseppe

doi:10.1016/j.jinf.2021.07.008

Cited by 8 publications

(9 citation statements)

References 4 publications

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“…In our sample, the prevalence of myalgia as an onset symptom was also higher in those infected with the Delta variant, but differences did not reach statistical significance. On the contrary, Mattiuzzi et al reported no differences in onset-associated symptoms between these variants of concern; however, these authors analyzed Web searches of the general population [ 18 ]. Few studies have systematically compared differences in onset symptoms between SARS-CoV-2 variants [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant

Fernández‐de‐las‐Peñas

Cancela-Cilleruelo

Rodríguez‐Jiménez

et al. 2022

Pathogens

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This study compared associated-symptoms at the acute phase of infection and post-COVID-19 symptoms between individuals hospitalized with the Wuhan, Alpha or Delta SARS-CoV-2 variant. Non-vaccinated individuals hospitalized because of SARS-CoV-2 infection in one hospital during three different waves of the pandemic (Wuhan, Alpha or Delta) were scheduled for a telephone interview. The presence of post-COVID-19 symptoms was systematically assessed. Hospitalization and clinical data were collected from medical records. A total of 201 patients infected with the Wuhan variant, 211 with the Alpha variant and 202 with Delta variant were assessed six months after hospitalization. Patients infected with the Wuhan variant had a greater number of symptoms at hospital admission (higher prevalence of fever, dyspnea or gastrointestinal problems) than those infected with Alpha or Delta variant (p < 0.01). A greater proportion of patients infected with the Delta variant reported headache, anosmia or ageusia as onset symptoms (p < 0.01). The mean number of post-COVID-19 symptoms was higher (p < 0.001) in individuals infected with the Wuhan variant (mean: 2.7 ± 1.3) than in those infected with the Alpha (mean: 1.8 ± 1.1) or Delta (mean: 2.1 ± 1.5) variant. Post-COVID-19 dyspnea was more prevalent (p < 0.001) in people infected with the Wuhan variant, whereas hair loss was higher in those infected with the Delta variant (p = 0.002). No differences in post-COVID-19 fatigue by SARS-CoV-2 variant were found (p = 0.594). Differences in COVID-19 associated onset symptoms and post-COVID-19 dyspnea were observed depending on the SARS-CoV-2 variant. The presence of fatigue was a common post-COVID-19 symptom to all SARS-CoV-2 variants.

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Section: Discussionmentioning

confidence: 99%

Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant

Fernández‐de‐las‐Peñas

Cancela-Cilleruelo

Rodríguez‐Jiménez

et al. 2022

Pathogens

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“…While the Spike variations played an important role in enabling Delta to out‐compete other SARS‐CoV‐2 variants during the second pandemic wave in 2021, the role of non‐Spike mutations have been underexplored till date. 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 Variations across non‐Spike proteins like Nucleocapsid, ORF1a, ORF1b and ORF7b caused the divergence of sub‐lineages 21J and 21I Delta from the prototype 21A Delta. This rapid SARS‐CoV‐2 evolution might be a consequence of selection pressure in context to the differential host immune responses.…”

Section: Discussionmentioning

confidence: 99%

Emergence of a unique SARS‐CoV‐2 Delta sub‐cluster harboring a constellation of co‐appearing non‐Spike mutations

Banerjee

Mazumder

Roy

et al. 2023

Journal of Medical Virology

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Accumulation of diverse mutations across the structural and nonstructural genes is leading to rapid evolution of SARS‐CoV‐2, altering its pathogenicity. We performed whole genome sequencing of 239 SARS‐CoV‐2 RNA samples collected from both adult and pediatric patients across eastern India (West Bengal), during the second pandemic wave in India (April–May 2021). In addition to several common spike mutations within the Delta variant, a unique constellation of eight co‐appearing non‐Spike mutations was identified, which revealed a high degree of positive mutual correlation. Our results also demonstrated the dynamics of SARS‐CoV‐2 variants among unvaccinated pediatric patients. 41.4% of our studied Delta strains harbored this signature set of eight co‐appearing non‐Spike mutations and phylogenetically out‐clustered other Delta sub‐lineages like 21J, 21A, or 21I. This is the first report from eastern India that portrayed a landscape of co‐appearing mutations in the non‐Spike proteins, which might have led to the evolution of a distinct Delta subcluster. Accumulation of such mutations in SARS‐CoV‐2 may lead to the emergence of “vaccine‐evading variants.” Hence, monitoring of such non‐Spike mutations will be significant in the formulation of any future vaccines against those SARS‐CoV‐2 variants that might evade the current vaccine‐induced immunity, among both the pediatric and adult populations.

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“…Delta was first detected in India in late 2020 and revealed itself to be extremely diffusive, worldwide (ECDC, 2021) [30]. It also determined the sudden peaks of infections in multiple countries, even after the graph declined on account of massive vaccination drives [31][32]. Studies revealed that signature mutations across the Delta genome augmented its transmissibility and lowered the affinity for the neutralizing antibodies against previous variants [33][34].…”

Section: Discussionmentioning

confidence: 99%

Evolution of Delta variant by non-Spike signature co-appearing mutations: trailblazer of COVID-19 disease outcome

Banerjee

Mazumder

Roy

et al. 2022

Preprint

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The high transmissibility and infectivity of a SARS-CoV-2 variant is usually ascribed to the Spike mutations, while emerging non-spike mutations might be a serious threat to the current Spike-recombinant vaccines. In addition to mutations in structural Spike glycoprotein, rapid accumulation of mutations across non-structural genes is leading to continuous virus evolution, altering its pathogenicity. We performed whole genome sequencing of SARS-CoV-2 positive samples collected from different clinical groups from eastern India, during the second pandemic wave (April-May, 2021). In addition to the several common spike mutations in Delta variant, two mutually explicit signature constellations of non-spike co-appearing mutations were identified, driving symptomatic and asymptomatic infections. We attempted to correlate these unique signatures of non-Spike co-appearing mutations to COVID-19 disease outcome. Results revealed that the Delta strains harboring a unique constellation of 9 non-spike co-appearing mutations could be the wheeler and dealer of symptomatic infection, even post vaccination. The strains predominantly driving asymptomatic infection possessed 7 non-spike co-appearing mutations, which were mutually exclusive in contrast to the set of mutations causing symptomatic disease. Phylodynamic analysis depicted high probability of emergence of these unique sub-clusters within India, with subsequent spread worldwide. Interestingly, some mutations of this signature were selected in Omicron and IHU variants, which suggest that gradual accumulation of such co-existing mutations may lead to emergence of more “vaccine-evading variants” in future. Hence, unfaltering genome sequencing and tracking of non-Spike mutations might be significant in formulation of any future vaccines against emerging SARS-CoV-2 variants that might evade the current vaccine-induced immunity.

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Is diffusion of SARS-CoV-2 variants of concern associated with different symptoms?

Cited by 8 publications

References 4 publications

Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant

Associated-Onset Symptoms and Post-COVID-19 Symptoms in Hospitalized COVID-19 Survivors Infected with Wuhan, Alpha or Delta SARS-CoV-2 Variant

Emergence of a unique SARS‐CoV‐2 Delta sub‐cluster harboring a constellation of co‐appearing non‐Spike mutations

Evolution of Delta variant by non-Spike signature co-appearing mutations: trailblazer of COVID-19 disease outcome

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