Is Dietary Red Meat Kidney Toxic?

Goraya, Nimrit; Wesson, Donald E.

doi:10.1681/asn.2016060664

Cited by 6 publications

(7 citation statements)

References 16 publications

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“…High-protein diets that are rich in red meat accelerate the progression of both experimental and human CKD (12,13). The link between a high-protein diet and CKD ( Figure 2) suggests that one might obtain mechanistic insights from studying mammals that live almost exclusively on a high-protein diet, such as the Felidae family (felids) and Desmodontinae (vampire bats).…”

Section: [H1] High-protein Diets and Dehydrationmentioning

confidence: 99%

“…High-protein diets induce vasodilation of afferent renal arterioles, glomerular hypertension and hyperfiltration, which together accelerate the progression of pre-existing CKD in a variety of domestic and laboratory animals, including mice, rats and dogs (28). A high consumption of salt and animal proteins has also been linked to progression of CKD in humans (12,29), with increasing evidence indicating a greater effect of red meat consumption compared with that of other animal and vegetable protein sources (12,13).…”

Section: [H1] High-protein Diets and Dehydrationmentioning

confidence: 99%

“…In domestic cats, a transient (up to 50-fold) increase in urine uric acid occurs following the ingestion of purine-rich animal proteins compared with a purine-free diet, despite the presence of a uric acid-degrading enzyme (uricase) (60). In humans, consumption of animal proteins and/or purines also results in an acute rise in serum and urine uric acid levels (61,62), which is accompanied with a substantial acid load in urine that leads to a decrease in urine pH (13). A urine pH of <5 is extremely common in cats with uraemic manifestations (23), and a low urine pH (5.0-5.5) predicts stage 3 CKD in humans (63).…”

Section: [H1] High-protein Diets and Dehydrationmentioning

confidence: 99%

See 2 more Smart Citations

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

Stenvinkel

Painer²,

Kuro‐o

et al. 2018

Nat Rev Nephrol

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Many of the >2 million animal species that inhabit Earth have developed survival mechanisms that aid in the prevention of obesity, kidney disease, starvation, dehydration and vascular ageing; however, some animals remain susceptible to these complications. Domestic and captive wild felids, for example, show susceptibility to chronic kidney disease (CKD), potentially linked to the high protein intake of these animals. By contrast, naked mole rats are a model of longevity and are protected from extreme environmental conditions through mechanisms that provide resistance to oxidative stress. Biomimetic studies suggest that the transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) offers protection in extreme environmental conditions and promotes longevity in the animal kingdom. Similarly, during months of fasting, immobilization and anuria, hibernating bears are protected from muscle wasting, azotaemia, thrombotic complications, organ damage and osteoporosis - features that are often associated with CKD. Improved understanding of the susceptibility and protective mechanisms of these animals and others could provide insights into novel strategies to prevent and treat several human diseases, such as CKD and ageing-associated complications. An integrated collaboration between nephrologists and experts from other fields, such as veterinarians, zoologists, biologists, anthropologists and ecologists, could introduce a novel approach for improving human health and help nephrologists to find novel treatment strategies for CKD.

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Section: [H1] High-protein Diets and Dehydrationmentioning

confidence: 99%

Section: [H1] High-protein Diets and Dehydrationmentioning

confidence: 99%

Section: [H1] High-protein Diets and Dehydrationmentioning

confidence: 99%

See 1 more Smart Citation

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

Stenvinkel

Painer²,

Kuro‐o

et al. 2018

Nat Rev Nephrol

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“…In an associated editorial, Wesson and Goraya speculated that the cause of this may be increased metabolic acidosis associated with red meat. (18) One last point that must be kept in mind when evaluating this data was that the majority of the studies were done in a pre-renin-angiotensin system (RAS) blockade era. Now we have those drugs, as well as flozins and mineralocorticoid antagonists which are not just effective, but much less complicated to implement.…”

Section: Evidence Synthesismentioning

confidence: 99%

Protein Restriction for CKD: Time to Move On

2022

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“…As a strategy to reduce dietary phosphorus intake, several randomized trials have found that replacing foods high in phosphate additives with additive-free foods resulted in significant reductions in serum phosphate concentrations [84] without impacting nutritional status [85]. Approaches aimed at examining associations between diet and ESRD have begun to shift the focus from assessment of individual nutrients to diet patterns and type or quality of foods consumed [86]. As current evidence for traditional dietary restrictions has come into question, liberalization of the renal diet has been suggested [87].…”

Section: Phosphorus and Phosphorus-to-protein Ratiomentioning

confidence: 99%

Egg Intake in Chronic Kidney Disease

et al. 2018

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Patients with chronic kidney disease (CKD) are often instructed to adhere to a renal-specific diet depending on the severity and stage of their kidney disease. The prescribed diet may limit certain nutrients, such as phosphorus and potassium, or encourage the consumption of others, such as high biological value (HBV) proteins. Eggs are an inexpensive, easily available and high-quality source of protein, as well as a rich source of leucine, an essential amino acid that plays a role in muscle protein synthesis. However, egg yolk is a concentrated source of both phosphorus and the trimethylamine N-oxide precursor, choline, both of which may have potentially harmful effects in CKD. The yolk is also an abundant source of cholesterol which has been extensively studied for its effects on lipoprotein cholesterol and the risk of cardiovascular disease. Efforts to reduce dietary cholesterol to manage dyslipidemia in dialysis patients (already following a renal diet) have not been shown to offer additional benefit. There is a paucity of data regarding the impact of egg consumption on lipid profiles of CKD patients. Additionally, egg consumption has not been associated with the risk of developing CKD based on epidemiological studies. The egg yolk also contains bioactive compounds, including lutein, zeaxanthin, and vitamin D, which may confer health benefits in CKD patients. Here we review research on egg intake and CKD, discuss both potential contraindications and favorable effects of egg consumption, and describe the need for further research examining egg intake and outcomes in the CKD and end-stage renal disease population.

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Is Dietary Red Meat Kidney Toxic?

Abstract: See related article, "mTOR Regulates Endocytosis and Nutrient Transport in Proximal Tubular Cells," on pages 230-241.

Cited by 6 publications

References 16 publications

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

Novel treatment strategies for chronic kidney disease: insights from the animal kingdom

Protein Restriction for CKD: Time to Move On

Egg Intake in Chronic Kidney Disease

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