Is diabetes associated with malaria and malaria severity? A systematic review of observational studies

Carrillo‐Larco, Rodrigo M.; Altez-Fernandez, Carlos; Ugarte-Gil, César

doi:10.12688/wellcomeopenres.15467.3

Cited by 11 publications

(7 citation statements)

References 30 publications

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“…HLA-A*24 is reported as "an independent predictor of 5-year progression to diabetes in autoantibody-positive first-degree relatives" of patients with Type I diabetes ( Mbunwe et al., 2013 ). Malaria is also associated with diabetes ( Danquah et al., 2010 ; Acquah, 2019 ; Carrillo-Larco et al., 2019 ). In the mentioned COVID-19 study ( Warren and Birol, 2020 ), HLA class II alleles DPA1*02:02 and DPB1*05:01 were found to be frequent as well.…”

Section: Discussionmentioning

confidence: 99%

Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide

Adıgüzel

2021

Acta Tropica

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Aim This study is looking for a common pathogenicity between SARS-CoV-2 and Plasmodium species, in individuals with certain HLA serotypes. Methods 1 . Tblastx searches of SARS-CoV-2 are performed by limiting searches to five Plasmodium species that infect humans. 2 . Aligned sequences in the respective organisms’ proteomes are searched with blastp. 3 . Binding predictions of the identified SARS-CoV-2 peptide to HLA supertype representatives are performed. 4 . Blastp searches of predicted epitopes that bind strongly to the identified HLA allele are performed by limiting searches to H. sapiens and Plasmodium species, separately. 5 . Peptides with minimum 60% identity to the predicted epitopes are found in results. 6 . Peptides among those, which bind strongly to the same HLA allele, are predicted. 7 . Step- 4 is repeated by limiting searches to H. sapiens , followed by the remaining steps until step- 7 , for peptides sourced by Plasmodium species after step -6 . Results SARS-CoV-2 peptide with single letter amino acid code CFLGYFCTCYFGLFC has the highest identity to P. vivax . Its YFCTCYFGLF part is predicted to bind strongly to HLA-A*24:02. Peptides in the human proteome both homologous to YFCTCYFGLF and with a strong binding affinity to HLA-A*24:02 are YYCARRFGLF, YYCHCPFGVF, and YYCQQYFFLF. Such peptides in the Plasmodium species’ proteomes are FFYTFYFELF, YFVACLFILF, and YFPTITFHLF. The first one belonging to P. falciparum has a homologous peptide (YFYLFSLELF) in the human proteome, which also has a strong binding affinity to the same HLA allele. Conclusion Immune responses to the identified-peptides with similar sequences and strong binding affinities to HLA-A*24:02 can be related to autoimmune response risk in individuals with HLA-A*24:02 serotypes, upon getting infected with SARS-CoV-2 or P. falciparum .

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Section: Discussionmentioning

confidence: 99%

Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide

Adıgüzel

2021

Acta Tropica

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“…Talking about resistant infections in the field of non-communicable diseases is new, yet some authors have already highlighted the links between communicable and non-communicable diseases. [5][6][7][8] A surveillance system of antibiotic resistance profiles among people with T2DM could be implemented to identify the most dangerous bacteria, select the best treatment considering other concomitant risk factor such as obesity, 86 and monitor trends of the resistance patterns in the T2DM community. An antibiotic resistance surveillance programme could inform local and international guidelines for infections in people with T2DM.…”

Section: Public Health and Clinical Practice Implicationsmentioning

confidence: 99%

“…[1][2][3][4] While much of the research about T2DM has focused on its determinants, consequences and complications regarding non-communicable diseases, T2DM as a risk and prognostic factor for infectiouscommunicable-diseases has gained attention lately. [5][6][7][8] In this relatively novel field-T2DM and infectious diseases-antibiotic resistance remains understudied, though it carries a large disease burden globally and in LMICs. [9][10][11][12][13] Large studies about T2DM and antibiotic resistance have focused on one pathogen or colonisation (rather than infection).…”

Section: Introductionmentioning

confidence: 99%

“…For example, some authors have suggested that T2DM is not an independent risk factor for urinary tract infections with resistant bacteria; 15 however, for communityacquired intra-abdominal infections, T2DM has been described as a potential risk factor. 16 The large burden of T2DM, [1][2][3][4] paired with its potential role as a risk and prognostic factor for infectious diseases, [5][6][7][8] along with the global issue of antibiotic resistance, [9][10][11][12][13] call to thoroughly study whether people with T2DM are at higher risk of infections with resistant bacteria. This knowledge may guide empirical treatment, with a subsequent positive impact on T2DM patients who would recover faster from infections, while also reducing the burden of antibiotic-resistant bacteria by prescribing more accurate treatments.…”

Section: Introductionmentioning

confidence: 99%

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Type 2 diabetes mellitus and antibiotic-resistant infections: a systematic review and meta-analysis

Carrillo‐Larco

Anza-Ramírez

Saal‐Zapata

et al. 2021

J Epidemiol Community Health

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BackgroundType 2 diabetes mellitus (T2DM) has been associated with infectious diseases; however, whether T2DM is associated with bacterial-resistant infections has not been thoroughly studied. We ascertained whether people with T2DM were more likely to experience resistant infections in comparison to T2DM-free individuals.MethodsSystematic review and random-effects meta-analysis. The search was conducted in Medline, Embase and Global Health. We selected observational studies in which the outcome was resistant infections (any site), and the exposure was T2DM. We studied adult subjects who could have been selected from population-based or hospital-based studies. I2 was the metric of heterogeneity. We used the Newcastle-Ottawa risk of bias scale.ResultsThe search retrieved 3370 reports, 97 were studied in detail and 61 (449 247 subjects) were selected. Studies were mostly cross-sectional or case–control; several infection sites were studied, but mostly urinary tract and respiratory infections. The random-effects meta-analysis revealed that people with T2DM were twofold more likely to have urinary tract (OR=2.42; 95% CI 1.83 to 3.20; I2 19.1%) or respiratory (OR=2.35; 95% CI 1.49 to 3.69; I2 58.1%) resistant infections. Although evidence for other infection sites was heterogeneous, they consistently suggested that T2DM was associated with resistant infections.ConclusionsCompelling evidence suggests that people with T2DM are more likely to experience antibiotic-resistant urinary tract and respiratory infections. The evidence for other infection sites was less conclusive but pointed to the same overall conclusion. These results could guide empirical treatment for patients with T2DM and infections.

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“…The prevention and control of NCDs should share equal importance with communicable diseases [ 15 ]. Prior studies have indicated that NCDs may be associated with malaria and malaria severity [ 16 – 18 ]. In several studies from Africa, malaria has been documented to be more common in people with diabetes [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Temporal trends in the burden of non-communicable diseases in countries with the highest malaria burden, 1990–2019: Evaluating the double burden of non-communicable and communicable diseases in epidemiological transition

Shi

et al. 2022

Global Health

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Background Non-communicable diseases (NCDs) are rapidly increasing in sub-Saharan African countries, where 96% of global malaria deaths occur. This study aimed to investigate the disease burden of NCDs in countries with the current highest malaria mortality. Methods Data for this study were obtained from the Global Burden of Disease 2019 study (1990–2019). We selected the ten countries with malaria’s highest age-standardised mortality rate (ASMR) and identified and ranked the five NCDs with the highest ASMR in each country. Measures of the NCDs disease burden included ASMR, age-standardised disability-adjusted life-years (DALY), years of life lost (YLL) and years lost due to a disability (YLD). The Estimated annual percentage change (EAPC) was used to examine the trends of the NCDs disease burden from 1990 to 2019. Results As of 2019, the ASMR of chronic liver disease, kidney disease, diabetes mellitus, Alzheimer’s disease and other dementias, hypertensive heart disease and stroke were higher than the global average. From 1990 to 2019, the ASMR for Alzheimer’s disease and other dementias, type II diabetes mellitus, and chronic kidney disease increased by 3.0%, 10.8%, 13.3%, and the age-standardised DALY rate increased by 3.7%, 27.6%, 6.3%, and the increases tended to be in younger populations. Conclusion The double burden of non-communicable and communicable diseases is crippling the health systems of many sub-Saharan African countries and is often neglected. The prevention, surveillance, and control of diseases require an integrated strategy, with governments and non-government organisations aligned and supported by the global initiative.

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Is diabetes associated with malaria and malaria severity? A systematic review of observational studies

Cited by 11 publications

References 30 publications

Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide

Peptides of H. sapiens and P. falciparum that are predicted to bind strongly to HLA-A*24:02 and homologous to a SARS-CoV-2 peptide

Type 2 diabetes mellitus and antibiotic-resistant infections: a systematic review and meta-analysis

Temporal trends in the burden of non-communicable diseases in countries with the highest malaria burden, 1990–2019: Evaluating the double burden of non-communicable and communicable diseases in epidemiological transition

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