Is deoxycholic acid able to reduce submental fat and increase patient satisfaction when compared to placebo groups? A systematic review

Vertuan, M.; Honório, H.M.; Queiroz, T.P.; Santos, Pâmela Letícia dos

doi:10.1016/j.bjps.2022.08.012

Journal of Plastic, Reconstructive & Aesthetic Surgery

2022

DOI: 10.1016/j.bjps.2022.08.012

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Is deoxycholic acid able to reduce submental fat and increase patient satisfaction when compared to placebo groups? A systematic review

M. Vertuan¹,

H.M. Honório²,

T.P. Queiroz³

et al.

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2024

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Cited by 2 publications

References 13 publications

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A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry

Rogerio,

Rabelo,

Roschel

et al. 2024

Journal of Oral Biology and Craniofacial Research

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A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry

Rogerio,

Rabelo,

Roschel

et al. 2024

Journal of Oral Biology and Craniofacial Research

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Deoxycholic Acid for Submental Convexity: A MAUDE Database Analysis

Gibson,

Kompelli,

Saadi

et al. 2024

Craniomaxillofacial Trauma & Reconstruction

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Study Design The study was a retrospective cross-sectional database analysis. Objective Deoxycholic acid (DOC) injections are a novel, in-office procedural alternative to submental liposuction or submentoplasty to address excess submental fat. Post-market safety data regarding this treatment is currently limited. The objective of this study is to analyze adverse events reported in the Manufacturer and User Facility Device Experience (MAUDE) database. Methods The MAUDE database was queried for all reports related to adverse events involving deoxycholic acid using the search terms “KYBELLA” and “deoxycholic acid.” Reports were individually reviewed by 2 reviewers and categorized with special attention to adverse events. Results A total of 34 medical device reports were identified from the database query. Thirteen of these reports (21 total events) were included in the analysis after excluding duplicates, unrelated adverse events, or events associated with the off-label use of DOC. Reported adverse events include excessive swelling (n = 5, 24%), marginal mandibular nerve weakness (n = 4, 19%), unsatisfactory aesthetic outcome (n = 4, 19%), numbness (n = 3, 14%), dysphagia (n = 1, 5%), infection (n = 1, 5%), and skin necrosis (n = 3, 14%). Two patients required hospitalization for skin necrosis management; both had underlying systemic diseases. Conclusions Adverse events following DOC injections included excessive swelling, dysphagia, numbness, infection, unsatisfactory aesthetic outcome, facial nerve weakness, and skin necrosis requiring hospitalization and/or surgery. Patient counseling regarding these adverse events should be discussed when offering DOC injections for submental convexity.

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Is deoxycholic acid able to reduce submental fat and increase patient satisfaction when compared to placebo groups? A systematic review

Cited by 2 publications

References 13 publications

A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry

A novel approach for deoxycholic acid administration to treat submental fullness: A case report assessed by 3D stereophotogrammetry

Deoxycholic Acid for Submental Convexity: A MAUDE Database Analysis

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