2019
DOI: 10.1080/17425255.2019.1650914
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Is curcumin bioavailability a problem in humans: lessons from clinical trials

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Cited by 166 publications
(107 citation statements)
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“…258 Further studies have confirmed the effects of curcumin on the Wnt/β-catenin and Hippo/YAP signaling pathways, inhibiting stemness or proliferation in multiple cancers. [259][260][261][262][263][264][265] Although limited bioavailability and stability hamper the application of curcumin in clinical cancer therapy, [266][267][268] curcumin has been used for treating patients with pancreatic cancer in clinical trials due to its anticancer activity and safety profile. 269,270 Drug repurposing of curcumin could prove beneficial for clinical translation using highly bioavailable forms of curcumin (e.g., micro-and nano-formulations of curcumin with greatly enhanced absorption) to target telomerase.…”
Section: Non-oncology Drugs In Drug Repurposingmentioning
confidence: 99%
“…258 Further studies have confirmed the effects of curcumin on the Wnt/β-catenin and Hippo/YAP signaling pathways, inhibiting stemness or proliferation in multiple cancers. [259][260][261][262][263][264][265] Although limited bioavailability and stability hamper the application of curcumin in clinical cancer therapy, [266][267][268] curcumin has been used for treating patients with pancreatic cancer in clinical trials due to its anticancer activity and safety profile. 269,270 Drug repurposing of curcumin could prove beneficial for clinical translation using highly bioavailable forms of curcumin (e.g., micro-and nano-formulations of curcumin with greatly enhanced absorption) to target telomerase.…”
Section: Non-oncology Drugs In Drug Repurposingmentioning
confidence: 99%
“…Curcumin clinical trials in different cancers are extensively done [ 135 ]. Clinical trials regarding curcumin treatment in bladder cancer demonstrated that 8000 mg/day of its dose for 3 months confer no side effects and has also attenuated bladder cancer lesions [ 136 ].…”
Section: Clinical Trials On Resveratrol Curcumin or Paclitaxel In Camentioning
confidence: 99%
“…Curcumin was shown to have anticancer and chemopreventive potential in different types of cancers, as discussed in several reviews [112][113][114]. Its relative non-toxicity allowed to overcome any biovailability concers, resulting in over 200 clinical trials investigating the protective role of curcumin against cardiovascular, metabolic, neurological, inflammatory and many other diseases [115]. It affects a wide range of cancer-related pathways, including inflammation, oxidative stress, apoptosis, and others.…”
Section: Modulation Of Tumorigenic Pathways As a Chemoprevention Stramentioning
confidence: 99%