Abstract:Aim and Hypothesis: Despite the proven symptomatic and mortality benefit of cardiac resynchronization therapy (CRT), there is anecdotal evidence it may be pro-arrhythmic in some patients. We aimed to identify if there were significant differences in the incidence of ventricular arrhythmias (VAs) in patients undergoing CRT-D and implantable cardioverter-defibrillators (ICD) implantation for primary prevention indication. We hypothesized that CRT is unlikely to be pro-arrhythmic based on the positive mortality a… Show more
“…In contrast, numerous studies concluded that CRT itself was not proarrhythmic, but had a protective effect for VT/VF depending on the level of LV improvement. A retrospective analysis comparing defibrillator therapies for primary prevention in 840 patients showed that there was no significant difference in the incidence of ventricular arrhythmias in the implantable cardioverter defibrillator (ICD) therapy compared to CRT‐D . Similarly, Blaschke et al.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies showed controversial results regarding the possible proarrhythmic effects of CRT . The proposed mechanism was that epicardial pacing of the LV resulting in a prolonged repolarization was the substrate for ventricular arrhythmias .…”
A negative ΔQRS, also called persistent ED, is associated with VT/VF. Narrowest possible QRSd might be a reliable goal of both implantation and optimization of devices to reduce arrhythmic events after CRT.
“…In contrast, numerous studies concluded that CRT itself was not proarrhythmic, but had a protective effect for VT/VF depending on the level of LV improvement. A retrospective analysis comparing defibrillator therapies for primary prevention in 840 patients showed that there was no significant difference in the incidence of ventricular arrhythmias in the implantable cardioverter defibrillator (ICD) therapy compared to CRT‐D . Similarly, Blaschke et al.…”
Section: Discussionmentioning
confidence: 99%
“…Previous studies showed controversial results regarding the possible proarrhythmic effects of CRT . The proposed mechanism was that epicardial pacing of the LV resulting in a prolonged repolarization was the substrate for ventricular arrhythmias .…”
A negative ΔQRS, also called persistent ED, is associated with VT/VF. Narrowest possible QRSd might be a reliable goal of both implantation and optimization of devices to reduce arrhythmic events after CRT.
CRT may significantly reduce risk of VA compared with ICDs in patients who meet criteria for CRT. CRT responders have significant reduction in VA compared with nonresponders. CRT nonresponse might significantly increase risk of VA.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.