Is COVID-19 a Systemic Disease?

Salim, Mohamed; Saad, Khaled; Elgohary, Ghada; Abdelhaffez, Azza; El‐Aziz, Nashwa Abd

doi:10.2174/2666796701999201216101914

Cited by 9 publications

(12 citation statements)

References 39 publications

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“…This could have important clinical implications. Healthcare providers should be sensitive to the distress and anxiety experienced by pregnant women with COVID-19, so that appropriate psychiatric referral could take place [3,[18][19][20][21][22][23]. Furthermore, the current study could have important clinical implications.…”

Section: Discussionmentioning

confidence: 95%

“…Risk factors for pregnancy-related psychopathology include unplanned pregnancy, stress associated with having common medical complications, fear of childbirth, peripartum cardiomyopathy, and pregnancy loss [ 18 ]. Despite the fact that COVID-19 has been around for more than two years, it still represents a real stressful condition, since it affects all body systems and no one is 100% immune [ 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

“…The coronavirus disease 2019 (COVID- 19) affected virtually all countries and had posed a significant threat to the health of the global population, with considerable direct and indirect psychological and social effects [1,2]. Some groups, like pregnant women, may be more vulnerable than others to the psychosocial effects of the pandemic [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Is the Modified Distress Thermometer Useful for Screening Pregnant Women With COVID-19 for Psychological Distress?

Mohamed¹,

Shaukat²

2022

Cureus

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Background: Pregnant women may be more vulnerable than others to the psychological and social effects of the coronavirus disease 2019 (COVID-19) pandemic. In this study, we try to answer the question -is the modified distress thermometer (m-DT) useful for screening pregnant women with COVID-19 for psychological distress? Methods: We have used the m-DT to screen pregnant women with COVID-19 for psychological distress. A total of 112 pregnant women with COVID-19 were prospectively enrolled. The study participants were asked to rate their distress in the past three days on an 11-point visual analog scale ranging from 0 (no distress) to 10 (extreme distress). They were then asked to fill in the problem list (PL) which accompanied the visual image of the m-DT. To explore the association between these scores and the clinical variables, binary logistic regression tests were carried out.Results: Sixty-eight percent (76/112) of the study subjects experienced significant (m-DT score ≥ 4) COVID-19-related distress. Regression analysis showed that m-DT score of ≥4 had statistically significant associations with gravida status length of quarantine time, the presence of chronic medical or respiratory disease, fears, worry, shortness of breath, and sleep. Multivariable analysis confirmed that the presence of chronic respiratory disease, shortness of breath, and sleep were independent factors associated with significant distress in pregnant women with COVID-19. Conclusion:With the use of m-DT, two-thirds of pregnant women with COVID-19 experienced significant distress. This distress was significantly related to older age, multigravida, exposure to longer quarantine time, presence of underlying medical disorder, and the presence of chronic respiratory disorders. The presence of chronic respiratory disease, shortness of breath, and sleep disturbance were independent factors associated with significant distress in pregnant women with COVID-19.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Is the Modified Distress Thermometer Useful for Screening Pregnant Women With COVID-19 for Psychological Distress?

Mohamed¹,

Shaukat²

2022

Cureus

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“…Announced by the World Health Organization in January 2020 as a global health emergency and in March 2020 as a pandemic, coronavirus disease 2019 (COVID-19) is a severe respiratory illness. 1 , 2 COVID-19 is highly infective, presenting with a range of symptoms; however, up to 80% of symptomatic COVID-19 infections feature only flu-like symptoms with no complications; 3 advanced complications such as renal or circulatory failure have been reported with severe cases or with other comorbidities or risk factors including old age, hypertension, cardiovascular diseases, or diabetes, especially type 1 diabetes mellitus (T1DM). 4 …”

Section: Introductionmentioning

confidence: 99%

Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes

et al. 2022

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Background Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. This study will not only shed light on such life-threatening complications but also be a step to increase the awareness of healthcare providers about such complications in the upcoming pandemic waves and increased dependence on telemedicine. Thus, we aimed to further investigate the increase of DKA in pediatrics. Methods PubMed, Web of Science, and Scopus were broadly searched for studies assessing the incidence of DKA in pediatrics during the COVID-19 pandemic. Results Our study included 24 papers with a total of 124,597 children with diabetes. A statistically significant increase occurred in the risk of DKA among newly diagnosed T1DM patients during the pandemic (RR 1.41; 95% CI 1.19, 1.67; p < 0.01; I 2 = 86%), especially in the severe form of DKA (RR 1.66: 95% CI 1.3, 2.11) when compared to before. Conclusion DKA in newly diagnosed children with T1DM has increased during the pandemic and presented with a severe form. This may reflect that COVID-19 may have contributed not only to the development but also the severity of DKA. Impact Diabetic ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus (T1DM) that has increased during the COVID-19 pandemic. Our study included 25 papers with a total of 124,597 children with diabetes. A statistically significant increase occurred in the risk of DKA among newly diagnosed T1DM patients during the pandemic. Our findings reflect that COVID-19 may have an altered presentation in T1DM and can be related to DKA severity.

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“…However, in most cases, the degree and type of lung injury are chiefly caused by the immune response to the viral infection rather than the direct impact of the virus itself. 2 …”

Section: Introductionmentioning

confidence: 99%

COVID-19 Infection in Patients with Comorbidities: Clinical and Immunological Insight

El‐Badawy

Elsherbiny

Abdeltawab

et al. 2022

Clin Appl Thromb Hemost

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Aim Our study's objectives were to study the clinical and laboratory characteristics that may serve as biomarkers for predicting disease severity, IL-10 levels, and frequencies of different T cell subsets in comorbid COVID-19 patients. Methods Sixty-two hospitalized COVID-19 patients with comorbidities were assessed clinically and radiologically. Blood samples were collected to assess the T lymphocyte subsets by flow cytometry and IL-10 levels by ELISA. Results The most common comorbidities observed in COVID-19 patients were diabetes mellitus (DM), hypertension, and malignancies. Common symptoms and signs included fever, cough, dyspnea, fatigue, myalgia, and sore throat. CRP, ferritin, D dimer, LDH, urea, creatinine, and direct bilirubin were significantly increased in patients than controls. Lymphocyte count and CD4+ and CD8+ T-cells were significantly decreased in comorbid COVID-19 patients, and CD25 and CD45RA expression were increased. CD4+ and CD8+ regulatory T cells (Tregs) and IL-10 levels were significantly decreased in patients. Conclusions Many parameters were found to be predictive of severity in the comorbid patients in our study. Significant reductions in the levels and activation of CD4+ and CD8+ T-cells were found. In addition, CD4+ and CD8+ Tregs were significant decreased in patients, probably pointing to a prominent role of CD8+ Tregs in dampening CD4+ T-cell activation.

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Is COVID-19 a Systemic Disease?

Cited by 9 publications

References 39 publications

Is the Modified Distress Thermometer Useful for Screening Pregnant Women With COVID-19 for Psychological Distress?

Is the Modified Distress Thermometer Useful for Screening Pregnant Women With COVID-19 for Psychological Distress?

Incidence of diabetic ketoacidosis during COVID-19 pandemic: a meta-analysis of 124,597 children with diabetes

COVID-19 Infection in Patients with Comorbidities: Clinical and Immunological Insight

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