Is copeptin a new potential biomarker of insulin resistance in polycystic ovary syndrome?

Widecka, Justyna; Ożegowska, Katarzyna; Banaszewska, Beata; Kazienko, Anna; Safranow, Krzysztof; Branecka-Woźniak, Dorota; Pawełczyk, Leszek; Kurzawa, Rafał

doi:10.5603/gp.2019.0021

Cited by 10 publications

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“…However, the precise mechanism underlying the relationship between gut microbiota and the occurrence and development of [4][5][6][7]. Exactly 50 % of patients with PCOS have IR, independent of obesity [30,31]. However, there is limited information on the roles played by intestinal flora in the development of IR and its link with PCOS.…”

Section: Discussionmentioning

confidence: 99%

The gut microbial composition in polycystic ovary syndrome with insulin resistance: findings from a normal‐weight population

2021

J Ovarian Res

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Background Limited studies have reported the relationship between intestinal flora dysbiosis and clinical characteristics in polycystic ovary syndrome (PCOS). However, the structure and characteristics of gut microbiota in PCOS have not been fully elucidated. Objective To analyze the composition of the Intestinal flora population in normal-weight women with PCOS and insulin resistance(IR) compared to PCOS alone and healthy women. Methods A total of 14 PCOS patients with insulin resistant(PCOS-IR) and 12 PCOS alone (PCOS-NIR), and 10 age- and body mass index-matched healthy control women (HC). BMI: 18.5–23.9 kg/m2. The bacterial 16 S rDNA V3-V4 fragment was amplified and sequenced. Then, the sequencing data were analyzed for species annotation, community diversity, and inter-group differences, to explore gut microbial characteristics of the subjects and their correlation with clinical parameters. Results No significant difference in diversity was observed between PCOA and sample cluster analysis among the three groups (Beta-diversity) and Alpha-diversity. The relative abundance of Rothia, Ruminococcus, and Enterococcus was significantly higher in the PCOS-IR group than in the other two groups (P < 0.05), while that of Prevotella was dramatically decreased (P < 0.05). The abundance of Enterococcus was positively correlated with waist circumference, hip circumference, diastolic blood pressure, and insulin resistance index. Meanwhile, Rothia abundance is positively associated with waist circumference and free fatty acids. Conclusions The gut microbial composition of PCOS patients with insulin resistance is different from that of PCOS alone and healthy women. The difference is correlated with the clinical characteristics of PCOS, with regards to insulin resistance, abdominal obesity, free fatty acids, and other indicators. PCOS-IR patients have an increased abundance of Enterococcus which potentially the intestinal environment of the host by enriching the metabolic pathways related to insulin resistance, causing the occurrence and development of PCOS.

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Section: Discussionmentioning

confidence: 99%

The gut microbial composition in polycystic ovary syndrome with insulin resistance: findings from a normal‐weight population

2021

J Ovarian Res

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“…Insulin resistance (IR) is considered the important pathological basis of reproductive dysfunction in patients with PCOS [4][5][6][7]. 50% of patients with PCOS have IR, independent of obesity [31,32]. However, there is limited information on the roles played by intestinal ora in the development of IR and its link with PCOS.…”

Section: Discussionmentioning

confidence: 99%

The gut microbial composition in polycystic ovary syndrome with insulin resistance: Findings from a normal-weight Population

2020

Preprint

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Background A few studies have reported on the relationship between intestinal flora dysbiosis and clinical characteristics in polycystic ovary syndrome (PCOS). But the structure and characteristics of gut microbiota in PCOS have not been fully elucidated. Objective To analyze the composition of the Intestinal flora population in normal-weight women with PCOS and insulin resistance(IR) compared to PCOS alone and healthy women. Methods The study included 14 PCOS patients with insulin resistant(PCOS-IR) and 12 PCOS alone༈PCOS-NIR༉,and 10 age- and body mass index-matched healthy control women. BMI: 18.5–23.9 kg/m2. The bacterial 16S rDNA V3-V4 fragment was amplified and sequenced. The sequencing data were analyzed for species annotation, community diversity, inter-group differences, to explore the composition characteristics of gut microbial of the subjects and their correlation with clinical parameters. Results No significant difference in diversity was observed between PCOA and sample cluster analysis among the three groups (Beta-diversity) and Alpha-diversity. The relative abundance of Rothia, Ruminococcus, and Enterococcus were significantly higher in the PCOS-IR group than in the other two groups (P < 0.05), whereas the abundance of the Prevotella was dramatically decreased (P < 0.05). The abundance of Enterococcus was positively correlated with waist circumference, hip circumference, diastolic blood pressure, and insulin resistance index. Meanwhile, Rothia abundance was positively associated with waist circumference and free fatty acids. Conclusion The gut microbial composition of PCOS patients with insulin resistance is different from that of PCOS alone and healthy women. The difference is correlated with the clinical characteristics of PCOS, with regards to insulin resistance, abdominal obesity, free fatty acids, and other indicators. PCOS-IR patients have an increased abundance of Enterococcus. It may affect the intestinal environment of the host by enriching the metabolic pathways related to insulin resistance, leading to the occurrence and development of PCOS.

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“…Patients diagnosed with PCOS according to Rotterdam criteria [1,2], were divided into two groups: "PCOS-obese"-26 overweight and obese patients [body mass index (BMI)>25kg/m 2 ] and 23 normal weight (PCOS-normal) and compared with 11 healthy controls, which included healthy volunteers with no menstrual cycle irregularities, no clinical hyperandrogenism and no polycystic ovarian morphology on the ultrasound. Controls did not have hormonal evaluation.…”

Section: Methodsmentioning

confidence: 99%

“…Medical history and clinical examination were taken. Blood samples for analysis were drawn and analyzed according to standard protocols [2].…”

Section: Methodsmentioning

confidence: 99%

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Can Total Thrombus-formation Analysis System (T-TAS®) better predict coagulation disturbances than conventional laboratory measurements in patients with polycystic ovary syndrome?

Ożegowska¹,

Mantaj²,

Rojewska³

et al. 2020

Polish Archives of Internal Medicine

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (CC BY-NC-SA 4.0), allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited, distributed under the same license, and used for noncommercial purposes only.

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Is copeptin a new potential biomarker of insulin resistance in polycystic ovary syndrome?

Cited by 10 publications

References 0 publications

The gut microbial composition in polycystic ovary syndrome with insulin resistance: findings from a normal‐weight population

The gut microbial composition in polycystic ovary syndrome with insulin resistance: findings from a normal‐weight population

The gut microbial composition in polycystic ovary syndrome with insulin resistance: Findings from a normal-weight Population

Can Total Thrombus-formation Analysis System (T-TAS®) better predict coagulation disturbances than conventional laboratory measurements in patients with polycystic ovary syndrome?

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