Is COPD associated with periodontal disease? A population-based study in Spain

López‐de‐Andrés, Ana; Vázquez-Vázquez, Luis; Martínez-Huedo, Maria A.; Hernández-Barrera, Valentín; Jiménez‐Trujillo, Isabel; Tapias-Ledesma, Miguel Angel; Miguel‐Díez, Javier de; Jiménez‐García, Rodrigo

doi:10.2147/copd.s174898

Cited by 29 publications

(30 citation statements)

References 35 publications

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“…First, this study employed a cross-sectional design; therefore, causal relationships between the variables could not be established. Consequently, the results should be interpretated with caution [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, the participants' questions arise from the need to collect information that any person can answer about the state of their teeth and molars. The generalization of National Health Surveys has already been used in other studies published in Spain where the association between periodontal disease and chronic obstructive pulmonary disease was evaluated [ 25 ].…”

Section: Discussionmentioning

confidence: 99%

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Self-reported prevalence of periodontal disease among the Spanish population and immigrants: 2006, 2011/12 and 2017: a population-based study

et al. 2021

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Background Periodontal disease is one of the most common pathologies in the population. Self-reporting has been used as a diagnostic tool in large populations, among other reasons, to detect the needs of potentially vulnerable groups. This study evaluated the prevalence of periodontal disease in people of Spanish nationality and immigrants in Spain. Methods This population-based, cross-sectional study was carried out using data obtained from National Health Interview Surveys (NHSs) carried out in 2006, 2011/2012 and 2017 in Spain. Subjects aged 16 years and older were included in the NHS-2006 and aged 15 years and older were included in the other NHSs. The following variables were self-reported by the participants: gum bleeding, tooth mobility, tooth extraction and missing teeth. Chi-square homogeneity tests were performed to assess the main associations between the independent variable (nationality) and the dependent variables (bleeding gums, tooth mobility, tooth extraction and missing teeth). Multinomial logistic regression models were constructed to evaluate the influences of the variables age and sex and their interactions on the main associations. Results A total of 115,123 participants were included in the NHS-2006 (n = 37,327, 11.38% immigrants), NHS-2011/12 (n = 38,727, 14.39% immigrants) and NHS-2017 (n = 39,069, 13.71% immigrants). The variables directly related to periodontal disease were gum bleeding and tooth mobility. These were significantly associated with nationality in the NHS-2006 and NHS-2017 cohorts. In the NHS-2011/12 cohort, only tooth mobility was associated with nationality. After adjustments for sex, age, and their interactions, immigrant status was associated with increased odds of bleeding in only the NHS-2006 cohort (RR = 1.65, 95% CI 1.38–1.99, p = 0.000). Conclusion Immigrants in Spain have a lower probability of developing signs associated with periodontal disease than the Spanish population. Among the immigrant cohort, females and those in adult age groups had lower prevalence rates than their counterparts.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Self-reported prevalence of periodontal disease among the Spanish population and immigrants: 2006, 2011/12 and 2017: a population-based study

et al. 2021

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“…9 A recent descriptive study suggested that the prevalence of periodontal disease was higher among those with COPD compared to non-COPD controls. 24 Another case-control study reported that oral health status was associated with selfreported respiratory health. 25 These results confirm the association between periodontitis and COPD.…”

Section: Discussionmentioning

confidence: 99%

<p>Periodontal Status and Microbiologic Pathogens in Patients with Chronic Obstructive Pulmonary Disease and Periodontitis: A Case–Control Study</p>

Zhou¹,

Wang²,

Liu³

et al. 2020

COPD

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Purpose: To evaluate clinical periodontal status and microbiologic pathogens in patients with chronic obstructive pulmonary disease (COPD) and periodontitis. Patients and Methods: We conducted a case-control study of 60 periodontitis patients with COPD (case group) and 60 periodontitis patients with normal pulmonary function (control group). Their periodontal status and respiratory function were clinically examined. Real-time polymerase chain reaction assays were used to measure five dental pathogens and four respiratory pathogens in subgingival dental plaque. Spearman's rank correlation coefficients (r 2) were calculated to assess correlations of pathogens. Principal component analysis (PCA) was employed to assess the similarity of bacterial diversity between the two groups. Logistic regression was performed to examine the associations of periodontal variables and pathogens with COPD risk. Results: COPD patients had fewer remaining teeth, higher plaque index (PLI), and more severe site percentages of clinical attachment level (CAL) than the controls. Although COPD patients tended to have relatively higher ranked means of Porphyromonas gingivalis, Tannerella forsythensis, Treponema denticola, and Haemophilus influenza than control participants, the differences were not significant. Some periodontal pathogens and respiratory pathogens were positively correlated with each other (r 2 =0.29 to 0.47, all P < 0.05). The PCA graph showed that the distributions of pathogens were more dispersed but less discriminated in the COPD group than those in the control group. PLI (P = 0.045) and CAL ≥ 5mm site percentages (P = 0.01) were significantly associated with an increased risk of COPD, while pathogens were not associated with COPD. Conclusion: Our results from this study do not indicate periodontal pathogens as potential predictors of COPD risk, despite significantly poor periodontal status associated with COPD.

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“…In this study using a nationally representative population, we could not find any statistically significant association between reduced lung function and the prevalence of chronic periodontitis. Although several studies in the literature evaluated the association between pulmonary diseases and periodontitis [22,23,30], it has not yet been determined how these two maladies affect each other. Evidence of a positive association between COPD and periodontitis comes from a meta-analysis of 14 observational studies [31], where a pooled association OR was reported as 2.08 (95% CI 1.48–2.91).…”

Section: Discussionmentioning

confidence: 99%

“…A systematic review study demonstrated that COPD patients suffer from worse periodontal condition [22]. A population-based study reported that the prevalence of periodontal disease was higher among COPD patients compared to non-COPD controls [23].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Periodontitis and Its Association with Reduced Pulmonary Function: Results from the Korean National Health and Nutrition Examination Survey

Lee

2019

Medicina

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Background and Objectives: The current study was performed to evaluate the prevalence of periodontitis and to examine the association between reduced pulmonary function and periodontitis using Sixth Korea National Health and Nutrition Examination Survey (KNHANES) in 2014. Materials and Methods: A cross-sectional evaluation was conducted to estimate the prevalence of periodontitis and to examine the association between periodontitis and reduced pulmonary function while adjusting for sociodemographic characteristics and current smoking status in survey participants between 40 and 79 years old. The presence of periodontitis was evaluated by community periodontal index defined by the World Health Organization, and the assessments of reduced pulmonary function data were made as “normal,” “restrictive impairment,” or “obstructive impairment.” Results: A total of 4004 survey participants representing 25.4 million Koreans were included in the study. Overall, 41.1% of the study population were determined to have periodontitis, and 22.1% had reduced pulmonary function; 7.9% and 14.2% had restrictive- and obstructive- pulmonary impairments, respectively. Age, male gender, and current smoking status were positive predictors for periodontitis. Insurance coverage by workplace and higher education were protective factors against periodontitis. The association between periodontitis and restrictive impairment (adjusted odds ratio (OR) = 1.059, 95% CI 0.729–1.540) or obstructive impairment (adjusted OR = 1.140, 95% CI 0.849–1.530) was not significant. Conclusions: For Koreans, 40–79 years old, age, smoking status, gender, education, and insurance coverage were significant predictors of periodontitis. The prevalence of periodontitis was not significantly associated with reduced pulmonary function. To better understand the relationship between periodontitis and reduced pulmonary function, well-designed and larger scale epidemiologic studies are needed.

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Is COPD associated with periodontal disease? A population-based study in Spain

Cited by 29 publications

References 35 publications

Self-reported prevalence of periodontal disease among the Spanish population and immigrants: 2006, 2011/12 and 2017: a population-based study

Self-reported prevalence of periodontal disease among the Spanish population and immigrants: 2006, 2011/12 and 2017: a population-based study

<p>Periodontal Status and Microbiologic Pathogens in Patients with Chronic Obstructive Pulmonary Disease and Periodontitis: A Case–Control Study</p>

Prevalence of Periodontitis and Its Association with Reduced Pulmonary Function: Results from the Korean National Health and Nutrition Examination Survey

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