Is cognitive impairment associated with antipsychotic dose and anticholinergic equivalent loads in first-episode psychosis?

Ballesteros, Alejandro; Sánchez‐Torres, Ana M.; López-Ilundain, Jose M.; Cabrera, Bibiana; Lobò, Antonio; González‐Pinto, Ana; Díaz‐Caneja, Covadonga M.; Corripio, Iluminada; Vieta, Eduard; Serna, Elena de la; Bobes, Julio; Usall, Judith; Contreras, Fernando Hernández; Lorente-Omeñaca, Ruth; Mezquida, Gisela; Bernardo, Miquel; Cuesta, Manuel J.

doi:10.1017/s0033291717003774

Cited by 51 publications

(47 citation statements)

References 75 publications

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“…However, it is important to note that this explains a low variance percentage both in functionality and in symptomatology. These findings indicate that, while this is an important factor in different outcomes, there are other variables that need attention: individual characteristics (including environmental risk factors, family support, treatments received, and aspects of symptomatology, cognition and personality) and antipsychotics dose , among others. Considering cognitive performance, CR predicts verbal memory, attention span, working memory, and global cognition in non‐affective psychotic patients.…”

Section: Discussionmentioning

confidence: 94%

Cognitive reserve as an outcome predictor: first‐episode affective versus non‐affective psychosis

Amoretti

Cabrera

Torrent

et al. 2018

Acta Psychiatr Scand

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CR plays a differential role in the outcome of psychoses according to the diagnosis. Specifically, in order to address the needs of non-affective patients with low CR, cognitive rehabilitation treatments will need to be 'enriched' by adding pro-cognitive pharmacological agents or using more sophisticated approaches. However, a functional remediation therapy may be of choice for those with an affective psychosis and low CR.

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Section: Discussionmentioning

confidence: 94%

Cognitive reserve as an outcome predictor: first‐episode affective versus non‐affective psychosis

Amoretti

Cabrera

Torrent

et al. 2018

Acta Psychiatr Scand

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“…In this sense, various studies have reported benefits on cognitive function and better performance on neurocognitive tasks in those patients who are treated with atypical vs. typical antipsychotics (e.g., Harvey and Keefe, 2001;Müller et al, 2005;Krakowski and Czobor, 2011). However, our result regarding the treatment variable, should be taken with caution for various reasons, first, we made a selection of patients by those who were taking typical, atypical and other medication not related to mental illness, but we did not perform a differentiation by calculating an estimate based on an average chlorpromazine equivalents (Gardner et al, 2010;Ballesteros et al, 2018). On the other hand, when assigning the patients to the different groups according to the type of pharmacological treatment, these are unbalanced, with the group of patients receiving atypical antipsychotics being much larger (N = 17), than the group of patients receiving antipsychotic treatment, typical (N = 4).…”

Section: Alterations In Cool and Hot Eeff Tasksmentioning

confidence: 97%

“Cool” and “Hot” Executive Functions in Patients With a Predominance of Negative Schizophrenic Symptoms

et al. 2020

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Background: Patients with psychosis often present significant neurocognitive deficits, with executive function deficits (EEFF) being one of the most relevant cognitive impairments with the greatest impact on the functioning of their daily lives. However, although various findings of executive involvement were reported, it is not entirely clear whether there is a differential pattern of involvement according to the clinical symptoms or the deficits occur in all or only in some subcomponents of EEFF.

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“…The antipsychotic treatment represents another factor with potential impact on cognitive function 34,35 , and a higher chlorpromazine equivalent dose was a predictor of worse performance in the visual learning domain in males, but not in females. However, males were treated with a higher dose of antipsychotic drugs in our sample.…”

Section: Discussionmentioning

confidence: 99%

Cognitive impairment and C-reactive protein in clinically stable schizophrenia outpatients: a focus on sex differences

Santo

González‐Blanco

García-Álvarez

et al. 2020

Sci Rep

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Although previous findings identified an association between C-reactive protein (CRP) levels, and impaired cognitive functions in patients with schizophrenia (SZ), little is currently known about the relationship between inflammation, cognition, and sex in SZ. The current study aimed to explore the association between peripheral inflammation and cognitive impairment in SZ as a function of sex. The sample included 132 clinically stable patients with SZ, of whom 82 were males (62.1%) and 50 females (37.9%). Sociodemographic data were collected, an accurate assessment was performed using the Positive and Negative Syndrome (PANSS), Clinical Assessment Interview for Negative Symptoms (CAINS), and Calgary Depression (CDS) scales, and the MATRICS Consensus Cognitive Battery (MCCB), and CRP levels were tested. A Pearson correlation and multiple regression analyses, including potential confounding factors, were performed. We found an inverse association between CRP levels and performance on visual learning (r = − 0.386, p = 0.006) domain in female patients only, whereas no correlations were found in males. The regression model for women retained age (β = − 0.319, p = 0.017), the CAINS-MAP score (β = − 0.247, p = 0.070), and the CRP (β = − 0.321, p = 0.013) as predictors of visual learning. Our results suggest the possible existence of sex-specific modulation of the association between systemic inflammation and the cognitive features of the illness.

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Is cognitive impairment associated with antipsychotic dose and anticholinergic equivalent loads in first-episode psychosis?

Abstract: Clinicians should be aware of the potential cognitive impairment associated with AP in advanced remission FEP, particularly in lower premorbid IQ patients.

Cited by 51 publications

References 75 publications

Cognitive reserve as an outcome predictor: first‐episode affective versus non‐affective psychosis

Cognitive reserve as an outcome predictor: first‐episode affective versus non‐affective psychosis

“Cool” and “Hot” Executive Functions in Patients With a Predominance of Negative Schizophrenic Symptoms

Cognitive impairment and C-reactive protein in clinically stable schizophrenia outpatients: a focus on sex differences

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