Is clinical outcome of dengue-virus infections influenced by coagulation and fibrinolysis? A critical review of the evidence

Mairuhu, A.T.; Gillavry, Mac; Setiati, TE; Soemantri, Augustinus; Cate, Hugo Ten; Brandjes, D. P. M.; Gorp, E. Van

doi:10.1016/s1473-3099(03)00487-0

Cited by 83 publications

(66 citation statements)

References 34 publications

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“…These complexes are taken up more easily than uncoated virus by cells expressing Fcr receptors, such as monocytes and macrophages. A series of cytokine cascades will follow with subsequent complement activation and increasing endothelium and vascular permeability (21). IFN-␥, TNF-␣, IL-2, IL-6, IL-1␤, and IL-8 are the cytokines involved in the pathogenesis of DHF/DSS (22).…”

Section: Discussionmentioning

confidence: 99%

Impact of Renal Failure on the Outcome of Dengue Viral Infection

Kuo¹,

Lu²,

Chang³

et al. 2008

Clinical Journal of the American Society of Nephrology

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Background and objectives: In the 2002 dengue outbreak in Taiwan, some fatal cases had the underlying disease of renal failure (RF). Physicians faced difficulty in diagnosis and treatment of these patients; however, the impacts of RF on the clinical presentations and outcomes of dengue infection have not been reported previously.Design, setting, participants, & measurements: A retrospective review was conducted of medical records, clinical presentations, laboratory findings, and underlying diseases for all cases of dengue infection in a medical center. Characteristics and outcomes of dengue-infected patients with and without RF were compared.Results: From January 2002 through January 2003, 519 dengue-infected patients were enrolled, including 412 patients with classical dengue fever (DF) and 107 patients with dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS). Twelve patients died in this outbreak, and all had DHF/DSS. Twenty-one (4.0%) patients were defined as being in the RF group. The RF group had a higher mortality rate than non-RF group (28.6 versus 1.2%; P < 0.001). The severity of GFR impairment was associated with higher percentages of DHF/DSS (P ‫؍‬ 0.029) and mortality (P < 0.001). Differences in symptoms/signs and laboratory abnormalities between DF and DHF/DSS were significant in the non-RF group but not apparent in the RF group.Conclusions: The diagnosis and management of dengue infection among patients with RF must be cautious, because complicated clinical courses with a higher mortality rate were well observed.

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Section: Discussionmentioning

confidence: 99%

Impact of Renal Failure on the Outcome of Dengue Viral Infection

Kuo¹,

Lu²,

Chang³

et al. 2008

Clinical Journal of the American Society of Nephrology

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“…113 There are conflicting opinions about whether fibrinolysis or impairment of the fibrinolytic pathway occurs in dengue pathogenesis. 114 It is clear that the exact mechanisms contributing to dengue coagulopathy are incompletely understood and that a better understanding is needed to allow for improvements in supportive care.…”

Section: Coagulopathymentioning

confidence: 99%

The pathogenesis of dengue

Whitehorn

Simmons

2011

Vaccine

224

185

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“…Without proper treatment, it can lead to life-threatening dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) (1). In addition to thrombocytopenia and vascular leakage, abnormal coagulation and fibrinolysis leading to hemorrhage are hallmarks of DHF/DSS (2)(3)(4). Several different hypotheses, such as Ab-dependent enhancement of DENV infection and DENVinduced autoantibodies binding to platelets and endothelial cells, have been proposed to explain the possible roles of Abs in the pathogenesis of DHF/DSS (5-7).…”

Section: Engue Virus (Denv) Infection Is the Most Importantmentioning

confidence: 99%

Dengue Virus-Induced Autoantibodies Bind to Plasminogen and Enhance Its Activation

Chuang

Lei

Lin

et al. 2011

The Journal of Immunology

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Dengue virus infection can lead to life-threatening dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS) in patients. Abnormal activation of the coagulation and fibrinolysis system is one of the hallmarks associated with DHF/DSS patients. However, the mechanisms that cause pathology in DHF/DSS patients are still unclear. Because conversion of plasminogen (Plg) to plasmin (Plm) is the first step in the activation of fibrinolysis, Abs against Plg found in DHF/DSS patients may be important. Therefore, to investigate the specificity, function, and possible origin of these Abs, we generated several Plg cross-reactive mAbs from DENV-immunized mice. An IgG mAb, 6H11, which recognizes an epitope associated with a dengue envelope protein, demonstrated a high level of cross-reactivity with Plg. The 6H11 Ab was further characterized with regard to its effect on Plg activation. Using Plm-specific chromogenic substrate S-2251, we found that mAb 6H11 demonstrated serine protease activity and could convert Plg directly to Plm. The serine protease activity of mAb 6H11 was further confirmed using serine protease chromogenic substrate S-2288. In addition, we found several Plg cross-reactive mAbs that could enhance urokinase-induced Plg activation. Lastly, mAb 6H11 could induce Plm activity and increase the level of D-dimer (a fibrin degradation product) in both human and mouse platelet-poor plasma. Taken together, these data suggest DENV-induced Plg cross-reactive Abs may enhance Plg conversion to Plm, which would be expected to contribute to hyperfibrinolysis in DHF/DSS patients.

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Is clinical outcome of dengue-virus infections influenced by coagulation and fibrinolysis? A critical review of the evidence

Cited by 83 publications

References 34 publications

Impact of Renal Failure on the Outcome of Dengue Viral Infection

Impact of Renal Failure on the Outcome of Dengue Viral Infection

The pathogenesis of dengue

Dengue Virus-Induced Autoantibodies Bind to Plasminogen and Enhance Its Activation

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